Inclusion Criteria:

          -  Participants must have certain types of cancer such as breast cancer, pancreatic
             cancer, lung cancer, kidney cancer, skin cancer (melanoma), prostate cancer, and
             ovarian cancer

          -  Participants must have stopped other forms of treatment for the cancer

          -  In the expansion cohorts participants must be able and willing to provide a sample of
             the tumor before beginning treatment and a sample during the treatment. For certain
             tumor types, the result of a test on the tumor sample may exclude the participant from
             the study

          -  Participants must not be pregnant, and must agree to use birth control

          -  Participants must have progressed through or be intolerant to therapies with known
             clinical benefit

        Exclusion Criteria:

          -  Participants must not have a current untreated tuberculosis, lung disease, heart
             disease, uncontrolled HIV, autoimmune disease, active hepatitis B or C virus infection
             or using corticosteroids

          -  Participant must not have cancer that has spread to the brain

          -  Participant must not have received a vaccine within the last 30 days

          -  Participant must not have had bowel obstruction within the last 6 months, or
             intestinal surgery

          -  Participant must not have an infection that is currently being treated