Inclusion Criteria:

          1. Signed informed consent must be obtained prior to participation in the study.

          2. Age ≥ 18 years at the date of signing the informed consent form (ICF)

          3. Newly diagnosed with AML based on 2016 WHO classification (Arber et al 2016) and not
             suitable for intensive chemotherapy defined as: age ≥75, ECOG performance Status 2 or
             3, or any of the following comomorbitities: severe cardiac comorbities (including
             congestive heart failure, LVEF ≤ 50%, chronic stable Angina) , pulmonary comorbidity
             (DLCO ≤ 65% or FEVI ≤ 65%). moderate hepatic impairment (with total Bilirubin >1.5 to
             3x ULN) , renal impairment (eGFR≥ 30 ml/min/1.73m^2 to 45 30 ml/min/1.73m^2), or other
             comorbidity incompatible with intensive chemotherapy per Investigator assessement and
             approved by the Novartis Medical monitor)

          4. .Not planned for hematopoietic stem-cell transplantation (HSCT)

          5. .Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 , 2 or 3

        Exclusion Criteria:

          1. Prior exposure to TIM-3 directed therapy

          2. History of severe hypersensitivity reactions to any ingredient of study drug(s)
             (azacitidine, venetoclax or MGB453) or monoclonal antibodies (mAbs) and/or their
             excipients

          3. Current use or use within 14 days prior to randomization of systemic, steroid therapy
             (> 10 mg/day prednisone or equivalent) or any immunosuppressive therapy. Topical,
             inhaled, nasal, ophthalmic steroids are allowed. Replacement therapy, steroids given
             in the context of a transfusion are allowed and not considered a form of systemic
             treatment.

          4. Previous treatment at any time, with any of the following antineoplastic agents,
             approved or investigational; checkpoint inhibitors, venetoclax and hypomethylating
             agents (HMAs) such as decitabine or azacitidine.

          5. Active autoimmune disease requiring systemic therapy (e.g.corticosteroids).

          6. Live vaccine administered within 30 Days prior to randomization

        Other protocol-defined Inclusion/Exclusion may apply.