Inclusion Criteria:

          -  Has histologically confirmed diagnosis of advanced/unresectable MPM.

          -  Have at least one measurable disease, which is treatment naïve, assessed by the local
             site investigator per modified RECIST

          -  Has a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
             Performance Scale.

          -  Has a life expectancy of at least 3 months.

          -  Demonstrate adequate organ function

          -  Male participants are eligible to participate if they agree to remain abstinent or
             agree to use contraception unless confirmed to be azoospermic.

          -  A female participant is eligible to participate if she is not pregnant or
             breastfeeding, using contraceptives or is not a woman of child bearing potential
             (WOCBP).

        Exclusion Criteria:

          -  A WOCBP who has a positive pregnancy test within 72 hours prior to treatment
             allocation.

          -  Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD-L2 agent or with
             an agent directed to another stimulatory or co-inhibitory T-cell receptor

          -  Has previously received systemic anti-cancer therapy for MPM.

             o Participants who received (neo) adjuvant previously may be eligible, only if the
             last dose of chemotherapy was completed at least 6 months before registration. Such
             participants must have recovered from all AEs due to previous (neo) adjuvant therapies
             to ≤Grade 1 or baseline. Participants with ≤Grade 2 neuropathy may be eligible.

          -  Received radiation therapy to the lung that is > 30 gray (Gy) within 6 months of the
             first dose of trial treatment.

          -  Completed palliative radiotherapy within 7 days of the first dose of trial treatment.

             o Participants must have recovered from all radiation-related toxicities, not require
             corticosteroids, and not have had radiation pneumonitis.

          -  Had a major surgery within 3 months prior to the first administration in this study.

          -  Has received a live vaccine within 30 days prior to the first dose of study drug.

          -  Is currently participating in or has participated in a study of an investigational
             agent or has used an investigational device within 4 weeks prior to the first dose of
             study intervention.

          -  Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
             immunosuppressive therapy within 7 days prior the first dose of study drug.

          -  Has a known additional malignancy that is progressing or has required active treatment
             within the past 5 years.

             o Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of
             the skin, or carcinoma in situ (eg, breast carcinoma, cervical cancer in situ) that
             have undergone potentially curative therapy are not excluded.

          -  Has known active CNS metastases and/or carcinomatous meningitis.

          -  Has had a severe hypersensitivity reaction (≥Grade 3) to treatment a monoclonal
             antibody/components of the study intervention.

          -  Has a history of (non-infectious) pneumonitis that required steroids or has current
             pneumonitis.

          -  Is being treated for pericardial effusion, or has symptomatic ascites or pleural
             effusion. A participant who is clinically stable following treatment for these
             conditions is eligible.

          -  Has an active infection requiring systemic therapy.

          -  Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the study, interfere with the participant's
             participation for the full duration of the study, or is not in the best interest of
             the participant to participate, in the opinion of the treating investigator.