Key Inclusion Criteria:

          -  Part 1: Solid tumors of all histologies, including metastatic, locally advanced, or
             recurrent after at least one prior line of standard therapy and requiring further
             treatment; OR malignant tumors for which no standard therapy exists, with or without
             prior therapy.

          -  Part 2: Histologically confirmed soft tissue sarcomas (STS), small cell lung cancer
             (SCLC), and non-small cell lung cancer (NSCLC), after at least one prior line of
             standard therapy and requiring further treatment. For STS subtypes for which no
             standard therapy exists, patients without prior therapy may be included.

          -  Measurable disease by RECIST v1.1

          -  Disease progression or recurrence (after treatment) within 6 months prior to
             enrollment

          -  Last dose of prior anti-cancer therapy should be performed at least 21 days prior to
             the first administration of study treatment.

          -  Life expectancy of ≥ 3 months at the time of enrollment.

          -  Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2

          -  Adequate baseline function within 28 days prior to enrollment:

               1. Bone marrow function: Absolute neutrophil count (ANC) ≥ 1,500/mm3; platelets ≥
                  100,000/mm3 , Hemoglobin ≥ 9.0 g/dL.

               2. Renal function: Creatinine clearance (calculated by Cockcroft-Gault) must be ≥ 30
                  ml/min.

               3. Hepatic function: Bilirubin ≤ 1.5 x upper limit of normal (ULN) or ≤ 3.0 x ULN
                  for subjects with Gilbert Syndrome; AST and ALT ≤ 3.0 × ULN.

               4. Coagulation profile: International normalized ratio (INR) is ≤ 2.0; absolute
                  prothrombin time (aPTT) < 1.5 x ULN.

          -  Left ventricular ejection fraction (LVEF) of > 50% by ECHO or MUGA within 56 days
             prior to enrollment.

          -  Two blood pressure readings with systolic blood pressure < 140 mmHg and diastolic
             blood pressure < 90 mmHg at screening with 28 days prior to enrollment.

          -  Provide written informed consent before any study-specific procedures are initiated.

        Key Exclusion Criteria:

          -  Major surgical procedure within 28 days or minor surgical procedure within 7 days
             prior to start of study treatment.

          -  History of prior or concurrent second primary malignancy that may interfere with the
             safety or efficacy assessment of the study treatment.

          -  Untreated, active central nervous system (CNS) metastases.

          -  Carcinomatous meningitis.

          -  Active, known, or suspected autoimmune disease or interstitial lung disease.

          -  Systemic treatment with corticosteroids or other immunosuppressive medications within
             14 days prior to start of study treatment.

          -  Active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis, or other
             gastrointestinal conditions with increased risk of perforation; history of abdominal
             fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior
             to start of study treatment.

          -  History of untreated deep venous thrombosis (DVT) within the past 6 months.

          -  Presence of uncontrolled infection.

          -  History of Class III or IV congestive heart failure according to New York Heart
             Association (NYHA) classification.

          -  History of any of the following cardiac conditions within 6 months prior to prior to
             start of study treatment:

               1. Cardiac angioplasty or stenting, or

               2. Myocardial infarction, or

               3. Unstable angina, or

               4. Cerebrovascular accident.

          -  Presence of any non-healing wound, fracture, or ulcer, or presence of symptomatic
             peripheral vascular disease.

          -  Evidence of bleeding diathesis or coagulopathy or clinically significant bleeding such
             as gross hematuria, gastrointestinal bleeding and hemoptysis within 6 months prior to
             start of study treatment.

          -  QTcF > 470 msec (per Fridericia's formula) on electrocardiogram within 28 prior to
             start of study treatment.

          -  Concurrent human Immunodeficiency virus (HIV) infection with CD4+ count < 350
             cells/uL.

          -  Known history of acquired immunodeficiency syndrome (AIDS) and an opportunistic
             infection within the past 12 months.

          -  Serologic evidence of chronic hepatitis B virus (HBV) via positive hepatitis B virus
             surface antigen (HBVsAg) or hepatitis C virus ribonucleic acid (HCV antibody) with a
             viral load above the limit of quantification.

          -  History of hepatitis C virus (HCV) infection without completion of curative antiviral
             treatment with a viral load above the limit of quantification.

          -  History of organ transplantation.

          -  Clinical conditions affecting the intake or absorption of AL3818 (e.g., inability to
             swallow, chronic diarrhea, intestinal obstruction, malabsorption disease, stomach or
             small bowel resection).

          -  Known allergies, hypersensitivity, or intolerance to protein-based therapies or with a
             history of any significant drug allergy (e.g., anaphylaxis, hepatotoxicity,
             immune-mediated thrombocytopenia or anemia.