Inclusion Criteria:

          1. Signed Informed Consent Form

          2. Male or female patients age ≥18 years at time of signing Informed Consent Form

          3. Ability to comply with the study protocol, in the investigator's judgment

          4. Histologically or cytologically confirmed advanced or metastatic gastroesophageal
             adenocarcinoma. Patients with HER2 positive cancer are permitted after having received
             HER2 targeted therapy in first line as per Standard of Care

          5. Disease progression during or following treatment with one or two lines of treatment
             for advanced disease, one of which must have been a platinum and fluoropyrimidine
             combination.

          6. Measurable, or non-measurable but evaluable, disease per RECIST v1.1

          7. Evidence of tumor mismatch repair proficiency and/or MSI stability through testing of
             a representative tumor tissue specimen using immunohistochemistry for MMR proteins or
             MSI testing. Local testing or historical results of archival tumour tissue is
             satisfactory for trial entry.

          8. ECOG 0-1

          9. Life expectancy ≥ 3 months as per physician judgment

         10. Adequate hematologic and end-organ function, defined by the following laboratory test
             results:

             a. ANC ≥ 1.5 x 109/L without granulocyte colony-stimulating factor support b.
             Lymphocyte count ≥ 0.5 x 109/L c. Platelet count ≥ 100 x 109/L without transfusion d.
             Hemoglobin ≥ 90 g/L (9 g/dL) (patients may be transfused to meet this criterion) e.
             AST, ALT, and alkaline phosphatase (ALP) ≤ 2.5 x upper limit of normal (ULN), with the
             following exceptions: i. Patients with documented liver metastases: AST and ALT ≤ 5 x
             ULN ii. Patients with documented liver or bone metastases: ALP ≤ 5 x ULN f. Serum
             bilirubin ≤ 1.5 x ULN with the following exception: i. Patients with known Gilbert
             disease: serum bilirubin level ≤ 3 x ULN g. Serum creatinine ≤ 1.5 x ULN or Creatinine
             clearance (CrCl) ≥ 50 mL/min (calculated using the Cockcroft-Gault formula)} h. Serum
             albumin ≥ 25 g/L (2.5 g/dL) i. For patients not receiving therapeutic anticoagulation:
             INR or aPTT ≤ 1.5 x ULN j. For patients receiving therapeutic anticoagulation: stable
             anticoagulant regimen k. Negative hepatitis B surface antigen (HBsAg) test at
             screening l. Negative total hepatitis B core antibody (HBcAb) test at screening, or
             positive total HBcAb test followed by quantitative hepatitis B virus (HBV) DNA < 500
             IU/mL at screening m. The HBV DNA test will be performed only for patients who have a
             positive total HBcAb test.

             n. Negative hepatitis C virus (HCV) antibody test at screening, or positive HCV
             antibody test followed by a negative HCV RNA test at screening o. The HCV RNA test
             will be performed only for patients who have a positive HCV antibody test.

         11. Tumour is amenable to safe repeated biopsies and patient agrees to undergo biopsies
             for translational endpoints.

         12. In patients who are receiving anticoagulation, stopping anticoagulation for biopsies
             must be deemed safe by the treating team.

         13. Patients on oral anticoagulation are required to change to low molecular weight
             heparin prior to study entry to be eligible.

         14. Willingness and ability to comply with the protocol for the duration of the study
             including scheduled visits, examinations, investigations and treatment plans

         15. Pregnancy must be excluded with a negative serum pregnancy test, within 7 days before
             initiation of therapy, if the risk of conception exists.

        Exclusion Criteria:

          1. Any contraindication or known hypersensitivity reaction to any of the study drugs

          2. Persisting toxicity relating to prior therapy of >grade 1 CTCAE version 5.0 except
             alopecia of any grade and neuropathy ≤ grade 2, or other grade ≤2 not constituting a
             safety risk based on investigators judgement

          3. Any prior treatment with immunotherapy including anti-PD-1or PD-L1 therapy

          4. Active or untreated CNS metastases are excluded. Patients with treated and
             asymptomatic CNS metastases are eligible, if they meet all of the following:

               1. Evaluable or measurable disease outside the CNS

               2. No metastases to midbrain, pons, medulla, or within 10 mm of the optic nerves and
                  chiasm

               3. No history or evidence of intracranial haemorrhage or spinal cord haemorrhage

               4. No evidence of clinically significant vasogenic oedema

               5. Not on corticosteroids for ≥ 2 weeks; anti-convulsants at a stable dose are
                  allowed

               6. No evidence of clinical and radiographic disease progression in the CNS ≥ 3 weeks
                  after radiotherapy or surgery

          5. Known severe hypersensitivity reactions to monoclonal antibodies (Grade ≥ 3 NCI CTCAE
             v 5.0), any history of anaphylaxis

          6. Any Immunodeficiency disorder

          7. Patients with another active malignancy or a prior malignancy within the past 5 years
             are excluded, except patients with completely resected cutaneous melanoma (early
             stage), basal cell carcinoma, cutaneous squamous cell carcinoma, cervical carcinoma
             in-situ, breast carcinoma in-situ, and localized prostate cancer are eligible

          8. History of autoimmune disease except for the following:

               1. Patients with autoimmune hypothyroidism on a stable dose of thyroid replacement
                  hormone are eligible

               2. Patients with controlled type 1 diabetes mellitus on a stable dose of insulin
                  regimen are eligible

               3. Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with
                  dermatologic manifestations only (e.g. patients with psoriatic arthritis) are
                  permitted provided that they meet the following conditions:

                    -  Patients with psoriasis must have a baseline ophthalmologic exam to rule out
                       ocular manifestations

                    -  Rash must cover less than 10% of body surface area

                    -  Disease is well controlled at baseline and only requiring low-potency
                       topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%,
                       flucinolone 0.01%, desonide 0.05%, aclometasone dipropionate 0.05%)

                    -  No acute exacerbations of underlying condition within the last 12 months
                       (not requiring PUVA [psoralen plus ultraviolet A radiation], methotrexate,
                       retinoids, biologic agents, oral calcineurin inhibitors, or high-potency or
                       oral steroids)

          9. History of idiopathic pulmonary fibrosis, organizing pneumonia, bronchiolitis
             obliterans, drug-induced pneumonitis, or idiopathic pneumonitis Patients with
             radiation pneumonitis within the radiation field are eligible

        12. Prior organ transplantation, including allogeneic transplant 13. Significant infection
        requiring systemic therapy 14. Known positive tests for human immunodeficiency virus (HIV)
        infection or known acquired immunodeficiency syndrome 15. History of inflammatory bowel
        disease 16. History of stroke, reversible ischemic neurological defect, or transient
        ischemic attack within 6 months prior to Day 1

        17. Proteinuria >grade 1 (≥ ULN - ≤1.0g/24hr) 18. Serum albumin < 2.5 g/dL 19.
        Administration of a live, attenuated vaccine within 4 weeks before randomization or
        anticipation of a live attenuated vaccine will be required during the study 20. Treatment
        with systemic immunostimulatory agents (including but not limited to interferons, IL-2)
        within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to Cycle 1 Day 1
        21. Treatment with systemic immunosuppressive medications (including but not limited to
        prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumour
        necrosis factor [TNF] agents) within 2 weeks prior to Cycle 1 Day 1 22. Cardiovascular
        diseases as follows:

          1. Unstable angina, new onset angina within last 3 months, myocardial infarction within
             last 6 months and current congestive heart failure New York Heart Association Class II
             or higher.

          2. Left ventricular ejection fraction (LVEF) below institutional lower limit of normal or
             below 50%, whichever is lower.

          3. Poorly controlled hypertension, defined as a blood pressure consistently above 150/90
             mmHg despite optimal medical management.

             23. Current signs or symptoms of any other severe progressive or uncontrolled hepatic,
             hematologic, gastrointestinal, endocrine, respiratory or cardiac disease, which in the
             opinion of the investigator, might impair the subject's tolerance of trial treatment
             or procedures.

             24. Major surgery, major trauma or open biopsy within 28 days prior to registration
             (not including staging laparoscopy) 25. Evidence of bleeding diathesis or coagulopathy
             26. Active non-healing wound, ulcer or bone fracture requiring therapy 27. Current
             lactation. Patients who agree to stop breastfeeding may be eligible.

             28. Other severe acute or chronic medical conditions or psychiatric conditions
             including recent (within the past year) or active suicidal ideation or behaviour; or
             laboratory abnormalities that may increase the risk associated with study
             participation or study treatment administration or may interfere with the
             interpretation of study results and, in the judgment of the investigator, would make
             the patient inappropriate for entry into this study.

             29. Uncontrolled tumour-related pain. Patients requiring narcotic pain medication must
             be on a stable regimen at study entry. Symptomatic lesions (e.g., bone metastases or
             metastases causing nerve impingement) amenable to palliative radiotherapy should be
             treated prior to start of study treatment.

             30. Uncontrolled pleural effusion, pericardial effusion or ascites requiring repeated
             drainage more than once every 28 days. Indwelling drainage catheters (e.g., PleurX®)
             are allowed.