Inclusion Criteria:

        A subject will be eligible to participate in Precision PromiseSM if all the below inclusion
        criteria are met:

          1. Age ≥ 18 years

          2. Histologically or cytologically confirmed metastatic pancreatic adenocarcinoma (PDAC)
             and eligible for treatment in the first line or second line settings. Note: prior
             adjuvant or neoadjuvant chemotherapy is permitted if the last dose was >12 months
             prior and all the other conditions below are met.

          3. Radiographically measurable disease of at least one site by computed tomography (CT)
             scan (or magnetic resonance imaging, if allergic to CT contrast media) as defined by
             Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Imaging results must be
             obtained within the 28-day window, prior to randomization.

          4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

          5. Adequate organ function (lab results must be obtained within the 28-day window prior
             to randomization)

               1. Absolute neutrophil count ≥ 1500/mm3

               2. Hemoglobin ≥ the lower limit of normal (LLN) or 9g/dL

               3. Platelets ≥ 100,000/mm

               4. Serum creatinine ≤ 1.0 x upper limit normal (ULN), or calculated creatinine
                  clearance ≥ 60 mL/min (Cockcroft Gault)

               5. Albumin ≥ 3.0 g/dL

               6. Aspartate aminotransferase (AST) serum glutamic oxaloacetic transaminase (SGOT)
                  and/or alanine aminotransferase (ALT) serum glutamic pyruvic transaminase (SGPT)
                  ≤ 2.5 x ULN (up to 5 x ULN in presence of liver metastasis).

               7. Total bilirubin ≤ 1.5 x ULN

               8. INR ≤ 1.5 x ULN

          6. Consent to provide protocol-mandated tissue and blood samples for diagnostic and
             research purposes.

          7. Able to swallow pills, capsules or tablets.

          8. Able to adhere to study visit schedule and other protocol requirements.

          9. Females of childbearing potential [defined as a sexually mature woman who (1) has not
             undergone hysterectomy (the surgical removal of the uterus) or bilateral oophorectomy
             (the surgical removal of both ovaries) or (2) has not been naturally postmenopausal
             for at least 24 consecutive months (i.e., has had menses at any time during the
             preceding 24 consecutive months)] must:

               1. Have a negative serum or urine pregnancy test (β-human chorionic gonadotropin
                  [β-hCG]) as verified by the study doctor within 14 days prior to randomization.

               2. Commit to complete abstinence from heterosexual contact or agree to use medical
                  doctor-approved contraception throughout the study without interruption while
                  receiving study treatment and for at least 6 months following last dose of study
                  treatment.

         10. Males must practice complete abstinence or agree to use a condom (even if he has
             undergone a successful vasectomy) during sexual contact with a pregnant female or a
             female of childbearing potential while participating in the study, during dose
             interruptions and for at least 6 months following last dose of study treatment.

         11. Understands the nature of the study and has agreed to participate by voluntarily
             signing the IRB approved informed consent.

        Exclusion Criteria:

          1. A subject will not be eligible to participate in Precision PromiseSM if any of the
             following criteria are met:

             a) Received any therapy within 28 days (or 5 half-lives, whichever is shorter,) prior
             to randomization.

          2. History of allergy or hypersensitivity to any of the study treatments or any of their
             excipients.

          3. Pre-existing peripheral neuropathy > Grade 1, as defined by CTCAE V 4.03.

          4. Known history of hepatitis B, HIV or active hepatitis C infection.

          5. Note: HIV testing is not required in the absence of clinical suspicion

          6. Serious, non-healing wound, ulcer, bone fracture, or abscess.

          7. The inability to swallow pills, capsules or tablets.

          8. Subjects who received a combination of two investigational agents as part of
             first-line therapy (novel + novel) are excluded. Subjects who received one
             investigational agent or one investigational agent combined with an FDA approved
             chemotherapy regimen in first line will be allowed to be enrolled in Precision
             PromiseSM for second line therapy.

          9. Any secondary malignancy that required chemotherapy treatment in the past two years

         10. History of interstitial lung disease, history of slowly progressive dyspnea and
             unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary
             hypersensitivity pneumonitis or multiple allergies.

         11. QTc > 450 msec if male and QTc > 470 msec if female.

         12. Uncontrolled or severe cardiac disease (history of unstable angina, myocardial
             infarction, coronary stenting, or bypass surgery within the prior 6 months),
             symptomatic congestive heart failure, serious uncontrolled cardiac arrhythmia
             [including atrial flutter/fibrillation], requirement for inotropic support or use of
             devices for cardiac conditions [pacemakers/defibrillators]).

         13. Active, uncontrolled infections (bacterial, viral, or fungal infection(s)) requiring
             systemic therapy, defined as ongoing signs/symptoms related to the infection without
             improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment
             (i.e., subjects must be afebrile for > 48 hours off antibiotics).

         14. Active, known or suspected autoimmune disease, including systemic lupus erythematosus,
             Hashimotos thyroiditis, scleroderma, polyarteritis nodosa or autoimmune hepatitis.

             a) Subjects with type I diabetes mellitus, hypothyroidism requiring only hormone
             replacement, skin disorders (such as vitiligo, psoriasis or alopecia) not requiring
             systemic treatment, or conditions not expected to recur in the absence of an external
             trigger are eligible to participate.

         15. Receiving immunosuppressive or myelosuppressive medications that would, in the opinion
             of the Investigator, increase the risk of serious neutropenic complications.

         16. Receipt of live vaccines within 30 days prior to the first dose of study treatment or
             while on active treatment within the trial. (examples of live vaccines include, but
             are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever,
             rabies, BCG, and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are
             generally killed virus vaccines and are permitted. However, intranasal influenza
             vaccines (e.g. Flu-Mist are live attenuated vaccines and are not permitted).

         17. Any significant medical condition, laboratory abnormality or psychiatric illness that
             would limit the subject's ability to comply with study requirements.

         18. Subjects that discontinued previous treatment for pancreatic adenocarcinoma due to a
             treatment-related Grade 3 toxicity.

               1. For toxicity discontinuations < Grade 3, AE(s) must resolve to Grade 1 or
                  baseline in order to be considered eligible for this trial.