Inclusion Criteria:

          1. Written informed consent in accordance with national, local, and institutional
             guidelines. The patient must provide informed consent prior to the first screening
             procedure. Informed consent form must be signed by the patient and the investigator.

          2. Age 60 to 75 years at the time of diagnosis of AML.

          3. Newly confirmed diagnosed of AML according to WHO 2008 criteria.

          4. Secondary or high risk AML, defined as one of the following:

               -  t-AML: documentation of prior cytotoxic therapy or radiation therapy for an
                  unrelated disease in a discharge summary or pharmacy records or radiation therapy
                  records

               -  MDSAML: bone marrow documentation of MDS prior to diagnosis of AML (could have
                  been treated previously with hypomethylating or standard chemotherapy)

               -  CMMoLAML: bone marrow documentation of CMMoL prior to diagnosis of AML (could
                  have been treated previously with hypomethylating or standard chemotherapy)

               -  de novoAML with FISH or cytogenetic changes linked to MDS per WHO 2016 criteria.

          5. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

          6. Ability to adhere to the study visit schedule and other protocol requirements.

          7. Laboratory values fulfilling the following:

               -  Serum creatinine < 2.0 mg/mL

               -  Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) or total
                  bilirubin < 3 times the upper limit of normal (ULN, subjects with elevated liver
                  enzymes related to disease were instructed to contact the Sponsor) (subjects with
                  Gilbert's Syndrome were instructed to contact the sponsor).

          8. Subjects with second malignancies in remission may have been eligible if there was
             clinical evidence of disease stability for a period ≥ 6 months off cytotoxic
             chemotherapy, documented by imaging, tumor marker studies at screening. Subjects
             maintained on long-term nonchemotherapy treatment such as hormonal therapy were
             eligible.

          9. Cardiac ejection fraction ≥ 50% assessed by echocardiography or MUGA.

         10. Eligible to receive intensive chemotherapy.

         11. Female patients of child-bearing potential must have a negative serum pregnancy test
             at screening and agree to use reliable methods of contraception for three months after
             their last dose of medication. Male patients must use a reliable method of
             contraception (if sexually active with a female of child-bearing potential).

         12. Willingness and ability to comply with scheduled visits, treatment plans, laboratory
             tests and other study procedures

        Exclusion Criteria:

          1. Patients with genetic diagnosis of acute promyelocytic leukemia.

          2. Age <60 years or >75 years.

          3. Blastic phase of bcr/abl chronic myeloid leukemia.

          4. Patients with de novo AML without FISH or cytogenetic changes linked to MDS per WHO
             2016 criteria.

          5. Clinical evidence of active central nervous system (CNS) leukemia.

          6. Subjects with active (uncontrolled, metastatic) second malignancies.

          7. Any major surgery or radiation therapy in 4 weeks.

          8. Subjects with myocardial impairment of any cause (eg, cardiomyopathy, ischemic heart
             disease, significant valvular dysfunction, hypertensive heart disease, and congestive
             heart failure) resulting in heart failure by New York Heart Association Criteria
             (Class III or IV staging).

          9. Uncontrolled infection; subjects with an infection receiving treatment (antibiotic,
             antifungal, or antiviral treatment) could be entered into the study provided the
             subject was respiratory and hemodynamically stable for ≥ 72 hours.

         10. Current evidence of invasive fungal infection (blood or tissue culture); subjects with
             recent fungal infection must have had subsequent negative cultures to be eligible;
             known HIV (new testing not required) or evidence of active hepatitis B or C infection
             (with rising transaminase values).

         11. Hypersensitivity to cytarabine, daunorubicin or liposomal products.

         12. Presence of any severe psychiatric disease or physical condition that, according to
             the physician´s criteria, contraindicates the inclusion of the patient into the
             clinical trial.

         13. Serum creatinine ≥ 20 mg/dL (unless it is attributable to AML activity).

         14. Bilirubin, alkaline phosphatase, or SGOT > 3 times the ULN (unless it is attributable
             to AML activity).

         15. Subjects with prior cumulative anthracycline exposure of greater than 368 mg/m2
             daunorubicin (or equivalent).

         16. History of Wilson's disease or other copper-metabolism disorder.

         17. Patients who have received an investigational agent (for any indication) within 5
             half-lives of the agent and until toxicity from this has resolved to grade 1 or less;
             if the half-life of the agent is unknown, patients must wait 4 weeks prior to first
             dose of study treatment.