Inclusion Criteria:

          -  Patients must meet all the following criteria for study entry:

               1. Written informed consent prior to screening procedures

               2. Be ≥18 years of age on the day of signing informed consent

               3. Have a confirmed diagnosis of MCL according to World Health Organization (2016)
                  criteria

               4. Have sufficient fresh or archival material available for central review

               5. At least one site of radiographically assessable disease not previously
                  irradiated (lymph node with largest diameter ≥1.5cm, or unequivocal evaluable
                  hepatomegaly/splenomegaly or marrow phase disease)

               6. Meet at least one of the following disease criteria:

                    -  Have relapsed, or progressed following at least 1 prior line of systemic
                       chemoimmunotherapy for MCL (may include ibrutinib or other BTK-inhibitor in
                       combination)

                    -  Be refractory to at least one prior line of chemoimmunotherapy (refractory
                       is defined as less than a conventional PR following 2 cycles of
                       anthracycline or cytarabine-containing therapy)

                    -  Have achieved <CR on PET imaging following 2 cycles of anthracycline or
                       cytarabine-containing therapy in the presence of aberrations of p53; or <CR
                       post autologous stem cell transplantation

                    -  Failure to achieve CR following at least 6 months of an ibrutinib or BTK
                       inhibitor -containing front-line regimen, or failure to achieve PR following
                       8 weeks of a BTK inhibitor

               7. Have a life expectancy of ≥ 3 months, as judged by the investigator

               8. Have acceptable haematological function within 7 days prior to registration,
                  defined as:

                    -  Absolute neutrophil count ≥1x10^9/L (may be supported by growth)

                    -  Absolute lymphocyte count ≥0.3x10^9/L or absolute CD3+ fraction > 0.15x
                       10^9/L

                    -  Platelets >50x 10^9/L unless explained by lymphoma at the discretion of the
                       CPI

                    -  Haemoglobin ≥ 80 g/L (may be transfusion supported)

               9. Have acceptable organ function within 7 days prior to registration, defined as:

                    -  Serum creatinine ≤1.5 x ULN, or a calculated creatinine clearance of at
                       least 50 mL/min using the Cockcroft-Gault equation (see appendix 1) or a
                       24-hour urine collection

                    -  AST or ALT ≤3.0 x ULN

                    -  Bilirubin ≤ 1.5 x ULN (with the exception of patients with Gilbert's
                       syndrome. Patients with Gilbert's syndrome may be included if their total
                       bilirubin is ≤3.0 x ULN and direct bilirubin ≤1.5 x ULN).

                    -  aPTT and PT ≤ 1.5x ULN

                    -  Adequate pulmonary function defined as:

          -  No or mild dyspnea (≤ grade 1)

          -  Oxygen saturation measured by pulse oximetry ≥ 90 percent on room air 10. Female
             patients of childbearing potential and non-sterile male patients (with partners of
             childbearing potential) must agree to use highly effective methods of contraception
             from registration on the study to 30 days after the last dose of ibrutinib and 12
             months after Tisagenlecleucel infusion and until Tisagenlecleucel is no longer present
             by qPCR on two consecutive tests (whichever is later):

               -  Total abstinence from sexual intercourse when this is in line with the preferred
                  and usual life style of the patient. Periodic abstinence (e.g., calendar,
                  ovulation, symptothermal, post-ovulation methods) and withdrawal are not
                  acceptable methods of contraception

               -  Female sterilisation (have had surgical bilateral oophorectomy with or without
                  hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks
                  prior to registration. In case of oophorectomy alone, only when the reproductive
                  status of the woman has been confirmed by follow-up hormone level assessment

               -  Male sterilisation (at least 6 months prior to screening). For female patients on
                  the study, the vasectomised male partner should be the sole partner for that
                  patient

               -  Use of oral, (estrogen and progesterone), injected or implanted hormonal methods
                  of contraception or placement of an intrauterine device (IUD) or intrauterine
                  system (IUS), or other forms of hormonal contraception that have comparable
                  efficacy (failure rate <1%), for example hormone vaginal ring or transdermal
                  hormone contraception. In case of use of oral contraception women should have
                  been stable on the same pill for a minimum of 3 months before enrolment into this
                  study.

        Women are considered post-menopausal and not of child bearing potential if they have had 12
        months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age
        appropriate history of vasomotor symptoms) or have had surgical bilateral oophorectomy
        (with or without hysterectomy), total hysterectomy or tubal ligation at least six weeks
        ago. In the case of oophorectomy alone, only when the reproductive status of the woman has
        been confirmed by follow-up hormone level assessment is she considered not of child bearing
        potential.

        11. Female patients of childbearing potential must have a negative serum (beta-human
        chorionic gonadotropin (β-hCG) or urine pregnancy test within 7 days of registration 12.
        Sexually active male patients must use a condom during intercourse and must agree to
        refrain from sperm donation, from registration on the study until 30 days after the last
        dose of ibrutinib or 12 months after Tisagenlecleucel infusion and until Tisagenlecleucel
        is no longer present by qPCR on two consecutive tests

        Exclusion Criteria:

          -  Patients who meet any of the following criteria will be excluded from study entry:

               1. Prior allogeneic transplantation

               2. Autologous transplantation within 6 weeks prior to registration

               3. Active and uncontrolled autoimmune cytopenias

               4. Active central nervous system involvement with MCL

               5. Previous treatment with adoptive T-cell therapy

               6. Receipt of a non BTK-inhibitor investigational medical product within the last 30
                  days prior to planned leukapheresis

               7. Receipt of a non-anti CD20- monoclonal antibody with anti-neoplastic intent
                  within 30 days prior to planned leukapheresis

               8. Receipt of steroids >20mg prednisolone or equivalent in the fortnight prior to
                  planned leukapheresis

               9. Requirement for ongoing therapy with:

                    -  Potent CYP3A inhibitors (e.g. indinavir, ketoconazole, clarithromycin)

                    -  Potent CYP3A inducers (e.g. rifampin, phenytoin, carbamazepine)

                    -  Vitamin K antagonists (e.g. warfarin or equivalent)

                    -  Antiretroviral medications

              10. Consumption within 3 days prior to registration:

                    -  Grapefruit or grapefruit products

                    -  Seville oranges

                    -  Star fruit

              11. Significant cardiovascular disease such as uncontrolled or symptomatic
                  arrhythmias, congestive heart failure or myocardial infarction within 6 months of
                  screening or class III to IV cardiac disease as defined by the New York Heart
                  Association Functional Classification

              12. Active neurological disorders of clinical relevance (e.g. epilepsy, severe brain
                  injury, dementia, Parkinson's disease or autoimmune/inflammatory disorders (e.g.
                  Guillain-Barre syndrome, motor neurone disease, chronic inflammatory
                  demyelinating polyneuropathy)

              13. Other significant life-threatening illness or medical condition which, in the
                  investigator's opinion, could compromise the subject's safety, interfere with
                  absorption or metabolism of study drug, or put the study outcomes at undue risk

              14. History of other active malignancy, with the exception of:

                    -  Adequately treated in situ carcinoma of the cervix or breast

                    -  Adequately treated basal cell carcinoma of skin or localised squamous cell
                       carcinoma of the skin

                    -  Previous malignancy confined and surgically resected (or treated with other
                       modalities) with curative intent and without evidence of recurrence for at
                       least 2 years prior to registration

              15. History of human immunodeficiency (HIV) or active hepatitis C virus or active
                  hepatitis B virus. NOTE: Serology must be repeated at the pre-conditioning stage
                  prior to infusion with Tisagenlecleucel.

              16. Clinically significant active infection confirmed by clinical evidence, imaging
                  or positive laboratory tests (e.g. blood cultures, viral DNA/RNA by PCR)

              17. Receipt of live, attenuated vaccines within 4 weeks of registration

              18. Major surgery within 4 weeks prior to registration

              19. Pregnant or nursing (lactating) women. Note: Women of child-bearing potential
                  must have a negative serum pregnancy test performed within 24 hours before
                  leukapheresis, lymphodepletion (if performed) and prior to Tisagenlecleucel
                  infusion.

              20. Known hypersensitivity to the excipients of Tisagenlecleucel or to any product to
                  be given to the patient as per the study protocol (e.g. tocilizumab and
                  lymphodepleting agents)