Inclusion Criteria

        The study population consists of adult patients with advanced solid tumors that meet all of
        the following criteria to be enrolled into this study:

          1. Age ≥ 18 years.

          2. Patients with histologically confirmed solid tumors with a likelihood of expression of
             GNX102 targeted antigens, which are limited to:

               -  colorectal

               -  hepatocellular

               -  non-small cell lung

               -  gastric

               -  breast

               -  bladder

               -  pancreatic

               -  melanoma (cutaneous, acral, or mucosal)

               -  esophageal

               -  prostate

               -  ovarian

               -  cervical

               -  epithelial uterine cancers.

          3. Patient has a paraffin block of non-necrotic tumor tissue available for
             immunohistochemistry (IHC) analyses, to be shipped prior to initiation of treatment.
             Processing includes an option to send formalin-fixed paraffin embedded slides [FFPE]
             slides if a tumor block is not available.

          4. Advanced, unresectable (local, regionally, recurrent not amenable to curative therapy)
             or metastatic disease that has no standard therapeutic option with a proven clinical
             benefit, are intolerant to or have refused all standard of care options with
             demonstrated clinical benefit.

          5. Expansion Phase only: patient has measurable disease per RECIST v 1.1 criteria.

          6. ECOG performance status of 0 or 1.

          7. Baseline QTC interval of ≤ 480 msec using Frederica's formula.

          8. Acceptable liver function:

               -  Bilirubin ≤ 1.5 times upper limit of normal

               -  AST (SGOT) and ALT (SGPT) ≤ 3 times upper limit of normal. If liver metastases
                  are present, then ≤ 5 x ULN is allowed, and

               -  Serum albumin ≥ 2.5 g/dL.

          9. Acceptable renal function, defined as calculated creatinine clearance > 30 mL/min per
             institution laboratory values.

         10. Acceptable hematologic status:

               -  Hemoglobin ≥ 8 g/dL (no packed red blood cell [PRBC] transfusions allowed within
                  2 weeks)

               -  Absolute neutrophil count (ANC) ≥ 1500 cells/mm^3 or ≥ 1.5 x 10^9/L

               -  Platelet count ≥ 100,000 platelets/mm^3 or ≥ 100 x 10^9/L, and

               -  Absolute reticulocyte count (x10^9/L) < ULN.

         11. Serum haptoglobin (mg/dL) > LLN.

         12. Acceptable coagulation status with fibrinogen, above LLN; PT/INR and PTT ≤ 1.5 times
             upper limit of normal (may be on a stable dose of coumadin with stable INR in the
             therapeutic range).

         13. Life expectancy of at least 3 months.

         14. Signed IRB-approved informed consent.

         15. Able and willing to comply with the protocol for the duration of the study, including
             undergoing treatment and scheduled visits and examinations.

         16. A negative serum pregnancy test, if female of child-bearing potential.

         17. For men and women of child-bearing potential, agreement to the use of at least 1
             highly effective contraceptive method(s) during the study and in the 3 months
             following the last dose of GNX102.

        Exclusion Criteria

        Patients who meet any of the following criteria will be excluded from participation in this
        study:

          1. Has any other malignancy not listed in Inclusion Criteria # 2.

          2. Has a positive PCR test for active COVID-19 infection or has signs or symptoms
             consistent with COVID-19 in the absence of a negative PCR test.

          3. Has New York Heart Association Class III or IV heart disease.

          4. History of myocardial infarction, unstable angina, coronary/peripheral artery bypass
             graft, within the past 6 months.

          5. History of cerebral vascular accident or transient ischemic attack within the past 6
             months.

          6. History of primary CNS tumor.

          7. History of CNS metastases, unless previously treated and stable for at least 4 weeks
             in the absence of steroids. Patients with meningeal carcinomatosis are excluded
             regardless of treatment.

          8. Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic
             therapy within 72 hours of start of therapy.

          9. Active, nonmalignant GI disease requiring treatment (such as inflammatory bowel
             disease, Crohn's disease, colitis) that would impart, in the judgment of the
             investigator and/or sponsor, excess risk associated with study participation or study
             drug administration, which would make the patient inappropriate for entry into this
             study.

         10. Clinical symptoms of pancreatitis within the past 28 days.

         11. Known active infection with HIV, hepatitis B (HBV), or hepatitis C (HCV).

               -  Patients with a history of HBV or HCV are allowed if HBV DNA or HCV RNA are
                  undetectable. Patients with hepatocellular cancer on anti-viral therapy must have
                  DNA levels ≤ 500 IU/ml.

               -  Patients with a history of HBV or HCV will be monitored for reactivation while on
                  study.

         12. Pregnant or nursing women.

         13. Treatment with radiation therapy within 14 days prior to dosing with GNX102.

         14. Major surgery within 14 days prior to dosing with GNX102.

         15. History of autoimmune hemolytic anemia or autoimmune thrombocytopenia.

         16. No second malignancy which is considered active or requires concurrent treatment.

         17. For patients with hepatocellular carcinoma

               -  Ascites requiring more than 1 paracentesis per month

               -  History of hepatic encephalopathy within 12 months of study entry.

         18. History of bleeding esophageal or gastric varices within 6 months of study entry.

         19. Prior or ongoing cancer treatment, including investigational treatment within 5
             half-lives or 21 days whichever is less, prior to dosing with GNX102 and 6 weeks for
             nitrosoureas or mitomycin C.

         20. Allergies to any excipients in GNX102 (i.e., L-histidine, sucrose, Polysorbate 80).

         21. Severe acute or chronic medical or psychiatric conditions or other laboratory
             abnormalities that would impart, in the judgment of the investigator and/or sponsor,
             excess risk associated with study participation or study drug administration, which
             would make the patient inappropriate for entry into this study.