Inclusion Criteria:

          1. Willing and able to provide written informed consent for the trial.

          2. Male or female subject ≥ 18 years.

          3. Subjects must have a histologically or cytologically confirmed locally advanced
             unresectable or metastatic HER2 positive solid tumor(s) for which no curative therapy
             is available or tolerable.

          4. Subjects must have at least one measurable lesion as defined per RECIST Version 1.1.

          5. Eastern Cooperative Oncology Group performance status of 0 or 1.

          6. Life expectancy ≥12 weeks.

          7. Serum bilirubin ≤ 1.5 × upper limit of normal (ULN), aspartate aminotransferase and
             alanine aminotransferase ≤ 2.0 × ULN OR ≤ 3.0 × ULN for subjects with liver
             metastases.

          8. Subjects (women of childbearing potential and males with fertile female partner) must
             be willing to use currently accepted reliable contraception method throughout the
             treatment period and for at least seven months following the last dose of study drug.

        Exclusion Criteria:

          1. Subjects receiving cancer therapy at the time of enrollment.

          2. Has not recovered from adverse events due to a previously administered agent.

          3. Had major surgery within 4 weeks before dosing.

          4. Use of any investigational anti-cancer drug within 28 days before the first
             investigational product administration.

          5. Subjects who have received prior cumulative doxorubicin dose > 360 mg/m² or equivalent

          6. Subjects with > Grade 2 peripheral neuropathy

          7. Has an active pneumonitis/interstitial lung disease (ILD), a history of
             pneumonitis/ILD that required systemic steroids, received radiotherapy to lung field
             within 12 months before the first dose of study intervention, or current clinically
             relevant lung disease

          8. Subjects with symptomatic or untreated central nervous system metastases, or those
             requiring ongoing treatment for central nervous system metastases, including steroids
             and antiepileptic agents.

          9. Any other serious underlying medical conditions, including but not limited to,
             uncontrolled diabetes mellitus, active uncontrolled infection, active gastric ulcer,
             uncontrolled seizures, cerebrovascular incidents, gastrointestinal bleeding, severe
             signs and symptoms of coagulation and clotting disorders.

         10. Subjects with clinically significant cardiovascular disease, current dyspnea at rest
             due to complications of advanced malignancy.

         11. Active viral hepatitis (B or C)

         12. History of life-threatening hypersensitivity, or known to be allergic to protein drugs
             or recombinant proteins

         13. Any other serious underlying medical conditions, including but not limited to,
             psychiatric, psychological, familial or geographical condition that, in the judgment
             of the investigator, may interfere with the planned staging, treatment and follow-up,
             affect subject compliance or place the subject at high risk from treatment-related
             complications

         14. Females who are pregnant