Inclusion Criteria:

        1. Age ≥18 years old. 2. Patients must have CML in CP or AP of any phenotype, with or
        without T315I mutation. 3. Be previously treated with and developed resistance or
        intolerance to at least two TKIs (such as imatinib, dasatinib, nilotinib, bosutinib or
        ponatinib).

          1. The definition of resistance to first-line TKI treatment refers to European Leukemia
             Net (ELN) recommendations. The definitions are the same for patients in CP and AP, and
             apply also to second-line treatment, when first-line treatment was changed for
             intolerance. The patients must meet at least one criterion. a) Three months after the
             initiation of therapy: Non-CHR and/or Ph+ >95%. b) Six months after the initiation of
             therapy: BCR-ABL1＞10% and/or Ph+ >35%. c) Twelve months after the initiation of
             therapy: BCR-ABL1＞1% and/or Ph+ >0%. d) Then, and at any time after the initiation of
             therapy：Loss of CHR, or loss of CCyR, or confirmed loss of MMR (In 2 consecutive
             tests, of which one with a BCR-ABL1 transcripts level≥1%), mutations, clonal
             chromosome abnormalities in Ph+ cells (CCA/Ph+).

          2. The definition of resistance to second-line TKI treatment. a) For CML CP patients: the
             patients must meet at least one criterion as follows.

             i) Three months after the initiation of therapy: No CHR or Ph+ >95% or new mutations.
             ii) Six months after the initiation of therapy: BCR-ABL1＞10% and/or Ph+ >65% and/or
             new mutations. iii) Twelve months after the initiation of therapy: BCR-ABL1＞10% and/or
             Ph+ >35% and/or new mutations. iv) Then, and at any time after the initiation of
             therapy: Loss of CHR or loss of CCyR, new mutations, confirmed loss of MMR (In 2
             consecutive tests, of which one with a BCR-ABL1 transcripts level≥1%), clonal
             chromosome abnormalities in Ph+ cells (CCA/Ph+). b) For CML AP patients: the patients
             must meet at least one criterion as follows.

             i) Three months after the initiation of therapy: failure to achieve a MaHR. Ascentage
             Pharma Group Inc. Protocol HQP1351CU101 47 / 88 ii) At any time after the initiation
             of therapy, the loss of a MaHR, confirmed in at least 2 consecutive analyses separated
             by at least 4 weeks. iii) At any time after the initiation of therapy, the development
             of new BCR-ABL kinase domain mutations in the absence of a MaHR.

          3. Intolerance to TKIs is defined as:

               1. Non-hematological AEs: patients with grade 3 or 4 toxicity during TKIs treatment,
                  or with persistent grade 2 toxicity, unresponsive to optimal management,
                  including dose adjustments in the absence of a CCyR for CP patients or MaHR for
                  AP patients.

               2. Hematological AEs: patients with grade 3 or 4 toxicity during TKIs treatment,
                  that is recurrent after unresponsive after optimal management, including dose
                  adjustments in the absence of a CCyR for CP patients or MaHR for AP patients. 4.
                  Patients providing written informed consent before initiation of any
                  study-related activities. 5. Eastern Cooperative Oncology Group (ECOG)
                  performance status ≤2. 6. Minimum life expectancy of 3 months or more. 7.
                  Patients with adequate organ function as defined below:

        1) Creatinine < 1.5 × upper limit of normal (ULN); or, creatinine > 1.5 × ULN, with 24h GFR
        ≥50Ml/min (Cockcroft-Gault). 2) Serum albumin ≥ 3.0 g/dL. 3) Total bilirubin < 1.5 ×ULN. 4)
        Aspartate aminotransferase (AST [Serum glutamic oxaloacetic transaminase (SGOT)]) and
        alanine aminotransferase (ALT [serum glutamate-pyruvate transaminase (SGPT)]) < 2.5 × ULN
        for institution (＜5×ULN if liver involvement with leukemia). 5) Serum amylase and lipase ≤
        1.5 × ULN. 6) Prothrombin time (PT) ≤ 1.5 × ULN. 8. Heart function: Left ventricular
        ejection fraction (LVEF) > 50%. 9. Normal QTcF interval on screening electrocardiogram
        (ECG) evaluation: male

          -  450ms，female ≤470ms. 10. For females of childbearing potential, a negative pregnancy
             test must be established before enrollment. And the eligible female and male patients
             with childbearing potential must agree to use an effective form of contraception with
             their sexual partners throughout participation in this study. 11. Ability to comply
             with study procedures, in the Investigator's opinion

        Exclusion Criteria:

          -  Received TKI therapy within 7 days prior to first dose of HQP1351, or, any adverse
             events (AEs) (except alopecia and pigmentation) not recovered to CTCAE v5.0 grade 0-1
             due to any other treatments. 2. Received other therapies as follows:

               1. For CP and AP patients, received hydroxyurea or anagrelide within 24 hours prior
                  to the first dose of HQP1351; or, interferon, immunotherapy or cytarabine within
                  14 days prior to the first dose of HQP1351; or, any other radiotherapy, cytotoxic
                  chemotherapy or investigational therapy within 28 days prior to receiving the
                  first dose of HQP1351.

               2. Patients who are currently receiving treatment with a medication that has the
                  potential to interact with HQP1351.

               3. Patients who had been treated with HQP1351.

               4. Patients requiring immunosuppressive therapy other than short time of steroid. 3.
                  Impairment of gastrointestinal (GI) function or GI disease that may significantly
                  alter absorption of study drugs. 4. Patients with cardiovascular diseases,
                  including uncontrolled high blood pressure (HBP) (that is blood pressure
                  >140/90mmHg.); or, receiving drugs that can cause prolonged QT interval. The
                  patients with well controlled HBP can be considered to be included. (the "well
                  controlled HBP" is defined as: HBP can be ≤ 140/90mmHg with antihypertensive
                  treatment; the range of fluctuation of blood pressure in recent 6 months has been
                  no more than 160/90mmHg). Those requiring 3 or more antihypertensive medications
                  should be discussed with the medical monitor. 5. Have experience of serious
                  cardiovascular AEs, such as myocardial infarction, unstable angina, severe
                  arrhythmias, congestive heart failure during previous TKIs treatment. 6. Have
                  history of autologous or allogeneic stem cell transplant, or with active GVHD, or
                  active immune suppression in recent 6 months prior to informed consent date. 7.
                  CML CP patients with CCyR; or, CML AP patients with MaHR. 8. Patients who have a
                  significant bleeding disorder unrelated to CML. 9. Patients who had a major
                  surgery within 4 weeks prior to study entry or have not recovered from side
                  effects of such surgery which the Investigator considers not appropriate for
                  enrollment. 10. Cytologically confirmed central nervous system (CNS) involvement
                  (if asymptomatic, spinal fluid examination is not necessary prior to first
                  treatment). 11. Patients with another primary malignancy within 1 years of study
                  entry. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are
                  not excluded if they Ascentage Pharma Group Inc. Protocol HQP1351CU101 49 / 88
                  have undergone complete resection and are considered disease-free at the time of
                  study entry. 12. Have ongoing or active infection, including known history of
                  immunodeficiency virus (HIV) or HIV antibody positive, hepatitis B virus (HBV) or
                  HBsAg positive, hepatitis C virus (HCV). Patients who have positive HCV antibody
                  must have an undetectable HCV viral load. 13. Known allergy to any components in
                  the study drug. 14. Pregnant or lactating. 15. Patients who have any conditions
                  or illness that, according to the opinions of the investigator or the medical
                  monitor, would comprise patient safety or interfere with the evaluation of safety
                  and efficacy to the study drug