Inclusion Criteria:

          1. Have a projected life expectancy of at least 12 weeks and be in stable condition to
             complete 1 full cycle (4 weeks) of treatment.

          2. Have histological confirmation of AML by World Health Organization (WHO) 2016 criteria
             and who have failed all other available conventional therapies.

          3. Have a peripheral blood or bone marrow blast count >5% at the time of enrollment.

          4. Have disease that:

               1. is refractory to standard induction chemotherapy, including but not limited to
                  anthracycline and cytarabine combination therapy, or

               2. has relapsed after anthracycline and cytarabine therapy or stem cell transplant
                  (SCT), or

               3. is refractory to or has relapsed after a front-line regimen containing a
                  hypomethylating agent, alone or in combination.

          5. Have an Eastern Cooperative Oncology Group (ECOG) Performance status of 0 to 1.

          6. Have adequate renal function as demonstrated by a serum creatinine ≤1.5 × upper limit
             of normal (ULN) or calculated creatinine clearance (by the standard Cockcroft-Gault
             formula) of ≥60 mL/min.

          7. Have adequate liver function as demonstrated by the following:

               1. aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <3 × upper
                  limit of normal (ULN)

               2. AST and ALT <5 × ULN (if considered due to leukemic organ involvement).

          8. Women of child-bearing potential (according to recommendations of the Clinical Trial
             Facilitation Group [CTFG]) must not be pregnant or breastfeeding and must have a
             negative pregnancy test at screening.

        Exclusion Criteria:

          1. Known clinically active central nervous system leukemia.

          2. BCR-ABL-positive leukemia.

          3. Diagnosis of acute promyelocytic leukemia (M3 AML or APML or APL).

          4. Second malignancy currently requiring active therapy, except breast or prostate cancer
             stable on or responding to endocrine therapy.

          5. Grade 3 or higher graft versus host disease (GVHD), or GVHD requiring treatment with
             either:

               1. a calcineurin inhibitor, or

               2. prednisone more than 5 mg/day (Note: Prednisone at any dose for other indications
                  is allowed).

          6. Total serum bilirubin ≥1.5 × ULN (except for subjects with Gilbert's Syndrome for whom
             direct bilirubin is >2.5 × ULN), or liver cirrhosis, or chronic liver disease
             Child-Pugh Class B or C.

          7. Known active human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis
             C virus (HCV) infection. Inactive hepatitis carrier status or low viral hepatitis
             titer being treated with antivirals is allowed. For subjects considered at risk of
             viral exposure, serologies should be used to establish negativity.

          8. Known significant mental illness or other condition such as active alcohol or other
             substance abuse or addiction that, in the opinion of the investigator, predisposes the
             subject to high risk of non-compliance with the protocol.

          9. Myocardial impairment of any cause (eg, cardiomyopathy, ischemic heart disease,
             significant valvular dysfunction, hypertensive heart disease, or congestive heart
             failure) resulting in heart failure by New York Heart Association (NYHA) Criteria
             (Class III or IV staging).

         10. Screening 12-lead echocardiogram with measurable QTc interval (according to either
             Fridericia's or Bazett's correction) of >480 milliseconds.

         11. Active, uncontrolled infection. Participants with an infection receiving treatment
             (antibiotic, antifungal, or antiviral treatment) must be afebrile and hemodynamically
             stable for ≥72 hours before enrollment.

         12. Non-AML-associated pulmonary disease requiring >2 liters per minute (LPM) oxygen.

         13. Proliferative AML with total white blood cells > 20,000/uL

         14. Any other condition that puts the participant at an imminent risk of death.

         15. Treated with any investigational therapy within 2 weeks of the first dose of study
             treatment.

         16. Inability to swallow oral medication.

         17. Known hypersensitivity to ATRA, any of its components, or other retinoids.

         18. Known sensitivity to parabens.