Inclusion Criteria:

          1. Adult females, pre- and/or post-menopausal, and adult males. Pre-menopausal (and
             peri-menopausal) women can be enrolled if amenable to treatment with an LHRH agonist.
             Patients are to have commenced concomitant treatment with LHRH agonist at least 4
             weeks prior to Cycle 1, Day 1 and must be willing to continue on it for the duration
             of the study

          2. Histologically confirmed HR+/HER2- breast cancer determined from the most recent
             tumour sample (primary or metastatic), as per the American Society of Clinical
             Oncology and College of American Pathologists guideline recommendations. To fulfil the
             requirement of HR+ disease, a breast cancer must express ER with or without
             co-expression of progesterone receptor.

          3. Metastatic or locally advanced disease with radiological or objective evidence of
             recurrence or progression; locally advanced disease must not be amenable to resection
             with curative intent (patients who are considered suitable for surgical or ablative
             techniques following potential down-staging with study treatment are not eligible)

          4. ECOG/WHO PS: 0-1

          5. Patients are to have received treatment with an AI containing regimen (single agent or
             in combination) and have:

               1. Radiological evidence of breast cancer recurrence or progression while on, or
                  within 12 months of the end of (neo)adjuvant treatment with an AI, OR

               2. Radiological evidence of progression while on prior AI administered as a
                  treatment line for locally advanced or metastatic breast cancer (this does not
                  need to be the most recent therapy)

          6. Patients must have measurable disease according to RECIST 1.1 and/or at least 1 lytic
             or mixed (lytic + sclerotic) bone lesion that can be assessed by CT or MRI; patients
             with sclerotic/osteoblastic bone lesions only in the absence of measurable disease are
             not eligible

          7. FFPE tumour sample from primary/recurrent cancer for central testing

        Exclusion Criteria:

          1. Symptomatic visceral disease or any disease burden that makes the patient ineligible
             for endocrine therapy per the investigator's best judgement

          2. More than 2 lines of endocrine therapy for inoperable locally advanced or metastatic
             disease

          3. More than 1 line of chemotherapy for inoperable locally advanced or metastatic
             disease. Adjuvant and neoadjuvant chemotherapy are not classed as lines of
             chemotherapy for advanced breast cancer

          4. Prior treatment with any of the following:

               1. AKT, PI3K and mTOR inhibitors

               2. Fulvestrant, and other SERDs

               3. Any other chemotherapy, immunotherapy, immunosuppressant medication (other than
                  corticosteroids) or anticancer agents within 3 weeks prior to study treatment
                  initiation.

               4. Potent inhibitors or inducers of CYP3A4 within 2 weeks prior to the first dose of
                  study treatment (3 weeks for St John's wort) or sensitive substrates of CYP3A4,
                  CYP2C9 and/or CYP2D6 with a narrow therapeutic window within 1 week prior to
                  study treatment initiation.

          5. Radiotherapy with a wide field of radiation up to 4 weeks before study treatment
             initiation (capivasertib/placebo) and/or radiotherapy with a limited field of
             radiation for palliation up to 2 weeks before study treatment initiation
             (capivasertib/placebo)

          6. With the exception of alopecia, any unresolved toxicities from prior therapy greater
             than CTCAE grade 1 at the time of starting study treatment

          7. Spinal cord compression or brain metastases unless asymptomatic, treated and stable
             and not requiring steroids up to 4 weeks before study treatment initiation

          8. Any of the following cardiac criteria:

               1. Mean resting corrected QT interval (QTc) >470 msec obtained from 3 consecutive
                  ECGs

               2. Any clinically important abnormalities in rhythm, conduction or morphology of
                  resting ECG (eg, complete left bundle branch block, third degree heart block)

               3. Any factors that increase the risk of QTc prolongation or risk of arrhythmic
                  events such as heart failure, hypokalaemia, potential for torsades de pointes,
                  congenital long QT syndrome, family history of long QT syndrome or unexplained
                  sudden death under 40 years of age or any concomitant medication known to prolong
                  the QT interval

               4. Experience of any of the following procedures or conditions in the preceding 6
                  months: coronary artery bypass graft, angioplasty, vascular stent, myocardial
                  infarction, angina pectoris, congestive heart failure New York Heart Association
                  (NYHA) grade ≥2

               5. Uncontrolled hypotension - systolic blood pressure <90 mmHg and/or diastolic
                  blood pressure <50 mmHg

               6. Cardiac ejection fraction outside institutional range of normal or <50%
                  (whichever is higher) as measured by echocardiogram (or multiple-gated
                  acquisition [MUGA] scan if an echocardiogram cannot be performed or is
                  inconclusive)

          9. Clinically significant abnormalities of glucose metabolism as defined by any of the
             following:

               1. Patients with diabetes mellitus type 1 or diabetes mellitus type 2 requiring
                  insulin treatment

               2. HbA1c ≥8.0% (63.9 mmol/mol)

         10. Known abnormalities in coagulation such as bleeding diathesis, or treatment with
             anticoagulants precluding intramuscular injections of fulvestrant or LHRH (if
             applicable)

         11. Currently pregnant (confirmed with positive pregnancy test) or breast-feeding