Abbreviated Inclusion Criteria:

          1. Age 18 years or older, is willing and able to provide informed consent

          2. Histologically confirmed diagnosis of unresectable or metastatic solid tumor
             malignancy in selected tumor types

          3. Life expectancy > 12 weeks

          4. ECOG performance status of 0-1

        Abbreviated Exclusion Criteria:

          1. History of allergy or hypersensitivity to study treatment components. Patients with a
             history of severe hypersensitivity reaction to any monoclonal antibody.

          2. Use of investigational agent within 28 days prior to the first dose of study treatment
             and throughout the study

          3. Receiving high-dose systemic steroid therapy or any other form of immunosuppressive
             therapy

          4. History of severe autoimmune disease

          5. Uncontrolled intercurrent illness or other active malignancy requiring ongoing
             treatment