Inclusion Criteria:

          -  Age: Patients must be less than or equal to 1 year and less than or equal to 30 years
             of age at initiation of protocol therapy.

          -  Diagnosis: Patients must have a confirmed histologic diagnosis of a relapsed or
             refractory solid tumor or CNS malignancy.

          -  Performance status: Patients over 16 years of age must have a Karnofsky score greater
             than or equal to 50. Children under 16 years of age must have a Lansky score greater
             than or equal to 50.

          -  Prior therapy: Patients may have received prior therapy with vincristine, irinotecan,
             or temozolomide. They may not however have received therapy that included a treatment
             cassette of irinotecan and temozolomide in combination.

               -  Prior myelosuppressive therapy: Patients must have not received myelosuppressive
                  therapy in 3 weeks or nitrosourea chemotherapy within 6 weeks of initiation of
                  protocol therapy.

               -  Hematologic growth factor support: Patients may not have received G-CSF within
                  the previous 3 days or peg-filgrastim within the past 7 days.

               -  Biologic anti-neoplastic therapy: At least 21 days or 5 half-lives (whichever is
                  of longer duration) must have elapsed since the last administration of biologic
                  antineoplastic therapy.

               -  Radiation therapy: ≥ 14 days since the last dose of local XRT; ≥ 6 months must
                  have elapsed if prior TBI, craniospinal XRT or ≥ 50% radiation of pelvis; ≥ 6 wks
                  must have elapsed if other substantial BM radiation.

               -  Autologous or allogeneic stem cell transplant: No active graft vs. host disease
                  or need for immunosuppressive therapy. At least 3 months must have passed since
                  neutrophil engraftment.

          -  Organ function:

        Bone marrow function:

          -  Peripheral absolute neutrophil count (ANC) greater than or equal to 1000 cells/mcL.

          -  Platelet count greater than or equal to100,000/mcL and no platelet transfusion within
             prior 7 days.

          -  Hemoglobin greater than or equal to 8 gm/dL

          -  Patients with known bone marrow metastatic disease may enroll on the study if they
             have a peripheral ANC greater than or equal to 750 cells/mcL. They will not be
             evaluable for hematologic toxicity.

             - Adequate liver function:

          -  Total bilirubin less than or equal to 1.5x upper limit of normal (ULN) for age.

          -  SGPT (ALT) less than or equal to 5x ULN

          -  Serum albumin greater than or equal to 2 gm/dL

             - Adequate renal function:

          -  Creatinine clearance or glomerular filtration rate >70 ml/min/1.73 m2 or a serum
             creatinine based on age and gender as follows:

        Age Maximum serum creatinine concentration (mg/dL) Male Female 1-<2 years 0.6 0.6 2-<6
        years 0.8 0.8 6-<10 years 1 1 10-<13 years 1.2 1.2 13-<16 years 1.5 1.4 greater than or
        equal to 16 years 1.7 1.4 The threshold creatinine values in this table were derived from
        the Schwartz formula to estimate glomerular filtration rates (Schwartz et al. J. Peds. 106;
        522. 1985) using child length and stature data from the CDC.

        - Informed consent: All patients less than 18 years of age must sign a written informed
        consent. For patients <18 years of age, a parent or guardian must sign a written informed
        consent, unless the patient is an emancipated minor. Childhood assent, when appropriate,
        should be obtained as well per institutional guidelines.

        Exclusion Criteria:

          -  Pregnancy or breast feeding: Women who are pregnant or breast feeding will not be
             entered on the protocol due to the risks of fetal and teratogenic adverse events with
             the therapeutic agents used in the protocol therapy.

          -  Corticosteroid use: Patients with CNS tumors who have not been on a stable or
             decreasing dose of corticosteroids for the 7 days prior to the initiation of protocol
             therapy.

          -  Antineoplastic therapy: Patients receiving any other antineoplastic therapy.

          -  Medication allergy:

        Allergy or intolerance to any of the protocol agents: vincristine, irinotecan,
        temozolomide, or vorinostat.

        Allergy or intolerance to cephalosporins.

          -  Infection: Patients who have any uncontrolled infection, positive blood culture within
             48 hours prior to protocol entry, or diagnosed or receiving therapy for Clostridium
             difficile infection.

          -  Patients may not have taken valproic acid or any other histone deacetylase inhibitor
             for at least 2 weeks prior to study enrollment.

          -  Children with neurofibromastosis Type 1, if being used for treatment of a low grade
             glioma.