INCLUSION CRITERIA:

        I1. Age 18 or older at the time of enrolment for women and age 60 or older at the time of
        enrolment for men.

        I2. Histologically or cytologically confirmed diagnosis of advanced or metastatic
        hematological or solid tumor (hematological or solid tumor, any type and any localization).

        I3. Documented diagnosis of COVID-19 (diagnostic test performed in a certified laboratory)
        without indication of transfer in a rescucitation unit.; Nota Bene : A maximum time of 7
        days may have elapsed between the date of first symptoms and the date of consent for
        patient cohort 1 (mild). In cohort 2 (severe), up to 10 days may have elapsed since the
        first symptoms.

        I4. Cohort 2: patients with pneumonia confirmed by chest imaging, and an oxygen saturation
        (Sao2) of 94% or less while they are breathing ambient air or a ratio of the partial
        pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) (Pao2:Fio2) at or below
        300 mg Hg.

        I5. Multidisciplinary approach that patient is not eligible for a transfer to Resuscitation
        Unit (either due to underlying medical condition - including cancer - or due to lack of
        available bed).

        Note: Item cancelled (addendum 2 - October 2020)

        I6. Life-expectancy longer than 3 months.

        I7. Adequate bone marrow and end-organ function defined by the following laboratory
        results:

          -  Bone marrow:

               -  Hemoglobin ≥ 9.0 g/dL,

               -  Absolute Neutrophils Count (ANC) ≥ 1.0 Gi/L,

               -  Platelets ≥ 100 Gi/L;

          -  Hepatic function:

               -  Total serum bilirubin ≤ 1.5 x ULN (except patients with Gilbert's syndrome who
                  must have total serum bilirubin ≤ 3.0 x ULN),

               -  AST/ALT ≤ 5 ULN

          -  Renal function:

               -  Serum creatinine ≤ 2.0 x ULN or Cr. Cl. ≥ 30ml/min/1.73m² (MDRD or CKD-EPI
                  formula);

        I8. Willingness and ability to comply with the study requirements;

        I9. Signed and dated informed consent indicating that the patient has been informed of all
        the aspects of the trial prior to enrollment (in case of emergency situation, please refer
        to protocol section 12.1 PATIENT INFORMATION AND INFORMED CONSENT);

        I10. Women of childbearing potential (Appendix 1) are required to have a negative serum
        pregnancy test within 72 hours prior to study treatment start. A positive urine test must
        be confirmed by a serum pregnancy test;

        I11. Women of childbearing potential and male patients must agree to use adequate highly
        effective contraception (Appendix 1) for the duration of study participation and up to 6
        months following completion of therapy;

        I12. Patient must be covered by a medical insurance.

        EXCLUSION CRITERIA:

        E1. For cohort 1 only: Patient currently receiving therapy with an anti-NKG2A.

        E2. For cohort 2 only: Patient currently receiving therapy with an anti-C5aR.

        E3. Patient presents a contraindication to monalizumab treatment (cohort 1 only) or to
        avdoralimab (cohort 2 only) as per respective IB, including known hypersensitivity to one
        of these study drugs or severe hypersensitivity reaction to any monoclonal antibody.

        E4. For cohort 1 only: Patient known to have intolerance or hypersensitivity to chloroquine
        or any quinoline derivatives (quinine, chloroquine, tafenoquine, hydroxychloroquine,
        mefloquine). Patients previously exposed to CQ, HCQ or other quinoline derivates should
        have interrupted their treatment at least 72h prior to randomization.

        E5. Patient has active autoimmune disease that has required systemic treatment in the past
        3 months before the date of randomisation or a documented history of clinically severe
        autoimmune disease, or a syndrome that requires systemic steroids at doses higher than 10
        mg/d prednisone equivalents or immunosuppressive agents.

        Note 1: Patients with vitiligo or resolved childhood asthma/atopy would be an exception to
        this rule. Patients that require intermittent use of bronchodilators or local steroid
        injections would not be excluded from the study. Patients with hypothyroidism stable on
        hormone replacement or Sjögren's syndrome will not be excluded from the study.

        Note 2: Patients may received corticosteroids as required for the management of
        SARS-CoV-2-related symptoms.

        E6. Patient requires the use of one of the following forbidden treatment during the study
        treatment period, including but not limited to :

          -  Major surgery

          -  Live vaccines. Examples of live vaccines include, but are not limited to, the
             following: measles, mumps, rubella, chicken pox, yellow fever and BCG. Seasonal
             influenza vaccines for injection are generally killed virus vaccines and are allowed;
             however intranasal influenza vaccines (e.g. Flu-Mist®) are live attenuated vaccines,
             and are not allowed.

        E7. Significant cardiovascular disease, such as New York Heart Association cardiac disease
        (Class II or greater), myocardial infarction within 3 months prior to the date of
        randomisation unstable arrhythmias or unstable angina, Known Left Ventricular Ejection
        Fraction (LVEF) < 50%.

        Note: Patients with known coronary artery disease, congestive heart failure not meeting the
        above criteria must be on a stable medical regimen that is optimized in the opinion of the
        treating physician and in consultation with a cardiologist if appropriate.

        E8. Patient has known active hepatitis B (chronic or acute; defined as having a positive
        hepatitis B surface antigen [HBsAg] test at screening), known active hepatitis C (Patients
        positive for hepatitis C virus (HCV) antibody are eligible only if PCR is negative for HCV
        RNA at screening) or known Human Immunodeficiency Virus (HIV) infection (HIV 1/2
        antibodies).

        E9. Prior allogeneic bone marrow transplantation or solid organ transplant in the past.

        E10. Has a history or current evidence of any condition, therapy, or laboratory abnormality
        that might confound the results of the trial, interfere with the subject's participation
        for the full duration of the trial, or is not in the best interest of the subject to
        participate, in the opinion of the treating Investigator.

        E11. Has known psychiatric or substance abuse disorders that would interfere with
        cooperation with the requirements of the trial.

        E12. Pregnant or breastfeeding patient, or expecting to conceive children within the
        projected duration of the trial, starting with the screening visit through 6 months after
        the last dose of study drugs.