Inclusion Criteria:

          1. 18 years of age at the time of study entry.

          2. Eastern Cooperative Oncology Group performance status of 0, 1, or 2.

          3. Life expectancy of .12 weeks as estimated by the treating physician.

          4. Metastatic carcinoma confirmed by biopsy or imaging study if biopsy is not deemed
             feasible.

          5. Most recent anti-cancer therapy consists of a single ICI drug including but not
             limited to ipilimumab, nivolumab, pembrolizumab, atezolizumab.

          6. Radiographic evidence of progression while on a single ICI drug in 1 and up to 5
             lesions.

          7. Eligible to continue ICI during and after radiation therapy.

          8. 3 radiographically distinct and measurable lesions (primary and/or metastatic lesions)
             by RECIST 1.1 criteria, with .3 lesions separated from each other by .5 cm

          9. Subjects must consent to all study procedures described in the protocol including
             radiographic evaluation and blood draws.

         10. Immunosuppressive doses of systemic medication including steroids must be discontinued
             at least 14 days prior to the start of radiation therapy.

         11. Adequate normal organ and marrow function

         12. Female subjects must either be of non-reproductive potential (i.e., post-menopausal by
             history: .60 years old and no menses for .1 year without an alternative medical cause;
             OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of
             bilateral oophorectomy), have a negative serum pregnancy test within 14 days of study
             enrollment, and not be breastfeeding.

        Exclusion Criteria:

          1. Any contraindication to having an MRI scan.

          2. Chemotherapy, biologic agent, investigational therapy, or radiation therapy given
             within 14 days of study enrollment.

          3. Symptomatic or uncontrolled brain metastasis requiring treatment.

          4. The need for palliative radiation therapy to a non-target lesion prior to radiation
             therapy to one of 2 target lesion on this study.

          5. Prior radiation therapy to any lesion that would receive radiation therapy on this
             protocol.

          6. Prior radiation therapy to a lesion located within 4 cm of previously irradiated
             structures: spinal cord that previously received >45 Gy; brachial plexus that
             previously received >45 Gy; small/large intestine or stomach that previously received
             >45 Gy; prior total lung V20 >30%.

          7. Prior radiation therapy that could lead to an unacceptably high risk of clinically
             significant normal tissue injury due to high cumulative normal tissue dose as
             determined by the investigator.

          8. History of any primary malignancy with the exception of

               1. Malignancy treated with curative intent and with no known active disease for at
                  least 3 years before enrollment on this study.

               2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
                  of disease.

               3. Adequately treated carcinoma in situ without evidence of disease (i.e. cervical
                  carcinoma in situ; superficial bladder cancer).

          9. Any unresolved toxicity (Common Terminology Criteria for Adverse Events version 5.0 >
             grade 2) from previous anti-cancer therapy. Subjects with irreversible toxicity that
             is not reasonably expected to worsen by treatment on this study are permitted to
             enroll on this study.

         10. Active or prior documented autoimmune disease within the past 2 years. Subjects with
             vitiligo, type I diabetes mellitus, Graves disease, or psoriasis not requiring
             systemic treatment (within the past 2 years) are not excluded.

         11. Subjects requiring systemic corticosteroid (>10 mg daily prednisone equivalent) or
             other immunosuppressive medication within 14 days of study enrollment.

         12. Contraindication to IV contrast despite premedication for iodine allergy, which would
             limit the ability to assess radiographic response to study treatment.

         13. Prior allogeneic organ transplantation.