Inclusion Criteria

          1. Diagnosis of muscle-invasive, non-metastatic urothelial carcinoma of the bladder,
             cT2-4, N0-1, M0

          2. Eligible to receive cisplatin-based chemotherapy, with eligibility defined as meeting
             all of the following criteria:

               1. Eastern Cooperative Oncology Group performance status of ¬0-1

               2. Creatinine clearance (CrCl) of >50 mL/min, as measured by 24-hour urine
                  collection or estimated by the CKD-EPI equation. Patients with CrCl between 50 -
                  60 mL/min are eligible for the study but will receive split dose cisplatin

               3. Grade < 2 hearing loss

               4. Grade < 2 peripheral neuropathy

               5. New York Heart Association Class < III heart failure

          3. Eligible to receive gemcitabine as dosed here

          4. Patients must have organ and marrow function meeting the criteria below:

             Absolute neutrophil count > 2,000/mcL Hemoglobin > 9.0 mg/mL Platelets > 100,000/mcL
             Total bilirubin within normal limits or known to be elevated due to a benign
             conjugation defect such as Gilbert's syndrome, as evidenced by normal conjugated
             bilirubin level AST/ALT < 3X institutional normal limits Creatinine clearance (CrCl) >
             50 mL/min/1.73m2, as measured with 24 hr urine collection or estimated by CKD-EPI,
             whichever is greater

          5. Signed, written informed consents to allow transfer of tumor tissue and production of
             peptides and to receive experimental treatment and monitoring if agreeable, or
             monitoring without experimental treatment otherwise

          6. Age ≥18 years

          7. Available fresh tissue from surgical excision. If fresh tissue is not available,
             archival tissue may be used.

          8. Female subjects of childbearing potential must have a negative serum pregnancy test at
             screening (within 72 hours of first dose of study medication). Non-childbearing
             potential (other than by medical reasons) is defined as 1 of the following:

               1. ≥ 45 years of age and amenorrheic for >1 year by self-report.

               2. Amenorrheic for >2 years without a hysterectomy and oophorectomy, and
                  follicle-stimulating hormone value in the postmenopausal range upon pretrial
                  (screening) evaluation.

               3. Status post-hysterectomy, -oophorectomy, or -tubal ligation. If of childbearing
                  potential, female subjects must be willing to use adequate birth control during
                  the study, starting with the screening visit through 120 days after the last dose
                  of study therapy.

        Male subjects with a female partner(s) of childbearing potential must agree to use a condom
        throughout the trial, starting with the screening visit through 120 days after the last
        dose of study therapy. Males with pregnant partners must agree to use a condom; no
        additional method of contraception is required for the pregnant partner.

        Note: Abstinence is acceptable for both female and male subjects if this is the subject's
        established and preferred contraception method.

        Exclusion Criteria

          1. Subjects must not have previously received a checkpoint inhibitor ie, anti-PD-1,
             anti-PD L1, or anti CTLA-4 antibody.

          2. Subjects must not have previously received anticancer medications or investigational
             drugs for the disease under study within the following windows:

             a. ≤ 28 days for prior monoclonal antibody used for anticancer therapy, with the
             exception of denosumab b. ≤ 7 days for immunosuppressive treatment for any reason,
             with the following exceptions: i. Physiologic steroid replacement for adrenal
             insufficiency (e.g., <10 mg prednisone per day) is permitted.

             ii. Use of inhaled or topical corticosteroid for radiographic procedures is permitted.

             c. Systemic corticosteroids < 7 days are not allowed except as defined above. d. ≤ 28
             days before first dose of study drug for all other investigational study drugs or
             devices

          3. Has persisting toxicity related to prior therapy of National Cancer Institute Common
             Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE) Grade >1 severity.

             Note: Sensory neuropathy or alopecia of Grade ≤2 is acceptable.

          4. Has known severe hypersensitivity reactions to fully human monoclonal antibodies
             (NCI-CTCAE Version 5.0 Grade ≥3), any history of anaphylaxis, or uncontrolled asthma.

          5. Active or history of any autoimmune disease (subjects with diabetes type 1, vitiligo,
             psoriasis, hypo- or hyperthyroid disease not requiring immunosuppressive treatment are
             eligible). Patients with a history of inflammatory bowel disease (including Crohn's
             disease and ulcerative colitis) and autoimmune disorders such as rheumatoid arthritis,
             systemic progressive sclerosis [scleroderma], Systemic Lupus Erythematosus or
             autoimmune vasculitis [e.g., Wegener's Granulomatosis] are excluded from this study.

          6. Any condition requiring systemic treatment with corticosteroids (>10mg daily
             prednisone equivalents) or other immunosuppressive medications within 14 days prior to
             first dose of study drug. Inhaled steroids and adrenal replacement steroids doses
             >10mg daily prednisone equivalents are permitted in the absence of active autoimmune
             disease.

          7. Uncontrolled intercurrent illness, including but not limited to uncontrolled
             infection, interstitial lung disease or active, non-infectious pneumonitis,
             symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac
             arrhythmia, or social situations that would limit compliance with study requirements
             in the opinion of the treating investigator or medical monitor.

          8. History of intolerance or allergic reactions attributed to compounds of similar
             chemical or biologic composition to AGEN1884 or AGEN2034.

          9. Women who are pregnant or breastfeeding.

         10. Receipt of a live vaccine within 30 days prior to the first dose of study drug.

         11. Inability to adhere to the protocol