Inclusion Criteria:

          1. Informed of the investigational nature of this study and has given written informed
             consent in accordance with institutional, local, and national guidelines;

          2. Histologically confirmed non-small-cell lung cancer (NSCLC) tumor stage IIIb or IV (3
             major types of NSCLC are acceptable including squamous, adenocarcinoma, and large cell
             carcinoma);

          3. Progressed on an approved PD-1 inhibitor or an approved PD-L1 inhibitor. Patients
             previously treated with a combination of an approved PD-1 or an approved anti-PD-L1
             inhibitor and chemotherapy may be included with agreement of Imugene Limited;

          4. Age of at least 18 years;

          5. Life expectancy of at least 12 weeks in the opinion of the Investigator;

          6. Tumor PD-L1 overexpression with Tumor Proportion Score (TPS) ≥ 50%. Participants with
             PD-L1 TPS ≥ 1% expression may be included with agreement of Imugene Limited;

          7. Zubrod/ECOG score performance status 0-1;

          8. At least one measurable lesion as defined by RECIST 1.1 criteria. Patients with
             non-measurable lesions may be included with agreement of Imugene Limited;

          9. Adequate hematologic function: Absolute neutrophil count (ANC) > 1.5x109/L, platelet
             count at > 100x109/L, and hemoglobin > 9 g/dL;

         10. Adequate liver function evidenced by bilirubin at < 1.5x laboratory upper limit of
             normal [ULN], and ALT and AST at < 3x laboratory ULN if no liver involvement or ALT
             and AST at < 5x laboratory ULN with liver involvement;

         11. Adequate renal function (creatinine at < 1.5x laboratory ULN);

         12. Willing and able to comply with scheduled visits, treatment plan, laboratory tests,
             and other study procedures;

         13. Male participants must agree to use a highly effective method of contraception
             throughout the study and for at least 180 days after the last dose of assigned
             treatment;

         14. If female, must be at least 2 years post-menopausal (defined as post-menopausal with
             at least 24 consecutive months without menstruation) or documented surgically sterile.

        Exclusion Criteria:

          1. Prior therapy for advanced NSCLC within 6 weeks prior to Day 1;

          2. Continuous systemic treatment with either corticosteroids (> 10 mg daily prednisone
             equivalents) or other immunosuppressive medications within 4 weeks prior to first dose
             of study treatment. Inhaled or topical steroids and physiological replacement doses of
             up to 10 mg daily prednisone equivalents are permitted in the absence of active
             auto-immune disease;

          3. Any previous grade 3 or higher toxicity to a PD-1 inhibitor or PD-L1 inhibitor;

          4. Known brain metastases requiring steroid treatment, or signs and symptoms indicating
             suspected brain metastases;

          5. Current or previous history of auto-immune disease;

          6. NSCLC expressing epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase
             (ALK), B-Raf proto-oncogene (BRAF) or ROS proto-oncogene 1 (ROS1) mutations;

          7. Prior organ transplant;

          8. Concurrent active malignancy except for adequately controlled limited basal cell
             carcinoma of the skin;

          9. History of uncontrolled seizures, central nervous disorders, or psychiatric disability
             judged by the Investigator to be clinically significant and precluding informed
             consent, participation in the study, or adversely affecting compliance to study drugs;

         10. Active infection requiring intravenous antibiotics;

         11. Positive for human immunodeficiency virus (HIV) (HIV 1/2 antibodies) or active
             hepatitis B (HBsAg reactive) or active hepatitis C (HCV ribonucleic acid [RNA]
             qualitative) infection;

         12. Major surgery within 4 weeks prior to study entry. Minor surgery (excluding diagnostic
             biopsy) within 1 week prior to study entry;

         13. Has received a live-virus vaccination within 4 weeks of first dose of IMU-201.
             Seasonal flu vaccines that do not contain live virus are permitted;

         14. Current or recent (within 6 weeks of first IMU-201 dose) treatment with another
             investigational drug or participation in another investigational study.