Inclusion Criteria:

        Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

        Diagnosed with histologically confirmed locally advanced and nonresectable, or metastatic
        disease.

        Phase 1a:

        Patients with urothelial carcinoma of the bladder, or squamous or non-Squamous NSCLC

        Phase 1b Expansion Cohort:

        Patients diagnosed with one of the following tumor types:

        A. Urothelial carcinoma of the bladder B. NSCLC, Squamous or Non-Squamous C. TNBC D.
        Cervical cancer E. MSS CRC

        Have progressed on treatment with an anti-PD-1/PD-L1monoclonal antibody (mAb) administered
        either as monotherapy, or in combination with other checkpoint inhibitors or other
        therapies (phase 1a, phase 1b cohort A or B) or with no prior anti-PD-1/PD-L1 therapy and
        failed standard of care treatment (phase 1b cohort C, D, or E).

        Have received no more than 3 prior lines of systemic therapy for advanced disease.

        Have provided archival tumor tissue sample or newly obtained core or excisional biopsy of a
        tumor lesion not previously irradiated.

        Left ventricular ejection fraction (LVEF) greater than 50% on echocardiography or multiple
        gated acquisition (MUGA) scan.

        Have adequate organ function.

        Exclusion Criteria:

        Have been discontinued treatment due to a Grade 3 or higher immune-related (irAE) from
        prior anti-PD-1or anti-PD-L1, or with an agent directed to another stimulatory or
        co-inhibitory T-cell receptor (eg, CTLA-4, OX 40, CD137)

        Have received prior systemic anti-cancer therapy including investigational agents within 4
        weeks or 5 half-lives, whichever is shorter prior to treatment.

        Have a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in
        dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
        immunosuppressive therapy within 7 days prior to the first dose of study drug.

        With a history of another primary malignancy within the past 2 years, with the exception of
        basal or squamous cell skin cancer, or carcinoma in situ of the cervix or breast that has
        undergone potentially curative therapy.

        Have known active CNS metastases and/or carcinomatous meningitis.

        Participants with known human immunodeficiency virus (HIV) and/or history of Hepatitis B or
        C infections, or known to be positive for Hepatitis B antigen (HBsAg)/ Hepatitis B virus
        (HBV) DNA or Hepatitis C Antibody or RNA.

        Prolongation of corrected QT.

        Significant cardiovascular impairment.

        Inability to take oral medication, or malabsorption syndrome or any other uncontrolled
        gastrointestinal condition (eg, nausea, diarrhea, or vomiting) that might impair the
        bioavailability of AN0025.

        Is pregnant or breastfeeding or expecting to conceive or father children within the
        projected duration of the study, starting with the screening visit through 120 days after
        the last dose of study treatment.