Inclusion Criteria:

          1. Patient must be ≥18 years of age

          2. Patients must have the following disease related criteria:

               -  any type of solid tumor malignancy (non-lymphoma) that is metastatic or
                  unresectable and considered relapsed and/or refractory to prior therapy

               -  must have evaluable disease.

               -  Archival formalin-fixed, paraffin-embedded (FFPE) tumor tissue

          3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

          4. Adequate organ and bone marrow function, in the absence of growth factors.

          5. Fertility criteria:

               -  Women of childbearing potential (WOCBP) and fertile males with WOCBP partners
                  must use highly effective contraception

               -  Women must agree not to donate eggs (ova, oocytes) for the purposes of assisted
                  reproduction

               -  Men must agree not to donate sperm

               -  A man who is sexually active with a woman of childbearing potential and has not
                  had a vasectomy must agree to use a highly effective method of birth control.

          6. Patient must be willing and able to adhere to the prohibitions and restrictions
             specified in the protocol. Due to the possibility of neurologic events, patient must
             agree to refrain from driving or engaging in hazardous occupations or activities such
             as operating heavy or dangerous machinery during the first cycle of treatment.

          7. Each patient must sign an informed consent form (ICF) indicating that he or she
             understands the purpose and procedures required for the study and is willing to
             participate in the study.

          8. Patient must have central venous access, such as port-a-cath, or peripherally inserted
             central catheter for at least the first cycle of treatment.

        Exclusion Criteria:

          1. Patient has any of the following medical situations:

               -  Uncontrolled intercurrent illness including, but not limited to: poorly
                  controlled hypertension; poorly controlled diabetes; ongoing active infection
                  requiring antibiotics or acute infectious illness (including suspected viral
                  infection); symptomatic congestive heart failure; unstable angina pectoris;
                  cardiac arrhythmia considered to increase risk for the patient by the
                  Investigator; psychiatric illness that would limit compliance with study
                  requirement

               -  Medical illness requiring systemic glucocorticoid use > 10mg/day prednisone
                  equivalent.

               -  Patients with history of brain metastasis

               -  Personal or familial history of hemophagocytic lymphohistiocytosis or macrophage
                  activation syndrome

               -  An autoimmune disease with a history of flares requiring immunosuppressant
                  medications within the past 6 months

               -  History of known or suspected seizure disorder

               -  Prior allogeneic organ or bone marrow transplant (BMT).

               -  Social situation that would limit compliance with study requirements

               -  Major surgery (eg, requiring general anesthesia) within 4 weeks before the
                  planned first dose of study drug, or not fully recovered from prior surgery, or
                  has surgery planned during the time the patient is expected to participate in the
                  study or within 4 weeks after the last dose of study drug.

               -  History of positive testing for hepatitis B surface antigen (HBsAg) or hepatitis
                  C antibody (anti-hepatitis C virus) or other clinically active liver disease, or
                  positive testing at screening for HBsAg or anti- hepatitis C virus.

               -  History of human immunodeficiency virus (HIV) antibody positive

          2. Patient has had prior therapy meeting the following:

               -  Anticancer immunotherapy within 3 weeks prior to the first dose of CI-8993

               -  Prior T Cell Receptor-modified or chimeric antigen receptor T cell (CART) therapy

               -  Other anticancer therapy, including chemotherapy, targeted therapy, or treatment
                  with an investigational anticancer agent within 2 weeks prior to the first dose
                  of CI-8993

               -  Radiotherapy (excluding limited palliative radiation) within 2 weeks of start of
                  CI-8993

               -  Unresolved toxicities from previous anticancer therapies above Grade 1.

               -  Immune-related AE with prior immunotherapy that was Grade 3 or higher.

               -  Patient has known allergies, hypersensitivity, or intolerance to components of CI
                  8993

          3. Patient receiving therapeutic anticoagulants

          4. Fertility exclusions:

               -  Patient is pregnant, breastfeeding, or planning to become pregnant while enrolled
                  in this study or within 3 months after the last dose of study drug; WOCBP must
                  have a negative pregnancy status confirmed by serum pregnancy test at screening
                  and within 72 hours of first dose of study drug.

               -  Patient is a man who plans to father a child while enrolled in this study or
                  within 3 months after the last dose of study drug.

          5. Vaccinated with a live vaccine within 28 days (with the exception of the annual
             inactivated influenza vaccine) prior to the first dose of study drug