Inclusion Criteria:

        Participants eligible for inclusion in the study must meet all inclusion criteria for this
        study.

          -  Sign and date the inform consent form (ICF) prior to the start of any study- specific
             qualification procedures.

          -  Adults ≥18 years (if the legal age of consent is >18 years old, then follow local
             regulatory requirements)

          -  Has pathologically documented NSCLC that:

               1. Has stage IIIB, IIIC, or stage IV NSCLC disease at the time of enrollment (based
                  on the American Joint Committee on Cancer, Eighth Edition).

               2. Has one or more of the following documented activating genomic alterations: EGFR,
                  ALK, ROS1, NTRK, BRAF, MET exon 14 skipping, or RET.

        KRAS mutations in the absence of any of the genomic alterations specified above will be
        excluded.

        Overexpression of EGFR, in the absence of activating mutations, is NOT sufficient for
        enrollment.

        Participants who have not received osimertinib should be evaluated for the presence of EGFR
        T790M mutation after relapse/progression on/after the most recent EGFR tyrosine kinase
        inhibitor (TKI), unless the participant is already known to be positive with document
        results for this mutation or unless osimertinib is not locally approved.

          -  Has documentation of radiographic disease progression while on or after receiving the
             most recent treatment regimen for advanced or metastatic NSCLC.

          -  Participant must meet the following for advanced or metastatic NSCLC:

               1. Has been treated with at least one but no more than two cytotoxic
                  agent-containing therapy in the metastatic setting:

                    -  One platinum-containing regimen (either as monotherapy or combination
                       therapy).

                    -  May have received up to one additional line of cytotoxic agent-containing
                       therapy.

                    -  Those who received a platinum-containing regimen as adjuvant therapy for
                       early stage disease must have relapsed or progressed while on the treatment
                       or within 6 months of the last dose OR received at least one additional
                       course of platinum-containing therapy (which may or may not be same as in
                       the adjuvant setting) for relapsed/progressive disease.

               2. May have received up to one checkpoint inhibitor (CPI)-containing regimen (may be
                  in combination with a cytotoxic agent as part of a regimen described above or as
                  an additional CPI regimen without a cytotoxic agent).

               3. Has been treated with 1 or more lines of non-CPI targeted therapy that is locally
                  approved for the participant's applicable genomic alteration at the time of
                  screening:

                    -  Those who received a targeted agent for the applicable genomic alterations
                       in the study as adjuvant therapy for early stage disease must have relapsed
                       or progressed while on the treatment or within 6 months of the last dose OR
                       received at least one additional course of targeted therapy for the same
                       genomic alterations (which may or may not be same agent used in the adjuvant
                       setting) for relapsed/progressive disease.

                    -  Participants who have been treated with a prior TKI must receive additional
                       targeted therapy, if clinically appropriate, for the genomic alterations
                       that are considered amenable or the participant will not be allowed in the
                       study.

          -  Must undergo a mandatory pre-treatment tumor biopsy procedure or if available, a tumor
             biopsy that was recently collected (within 3 months of screening) after completion of
             the most recent anticancer treatment regimen and that has a minimum of 10 × 4 micron
             sections or a tissue block equivalent of 10 × 4 micron sections may be substituted for
             the mandatory biopsy collected during screening.

          -  Measurable disease based on local imaging assessment using RECIST v1.1.

          -  Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 - 1 at screening.

        Exclusion Criteria:

        Participants meeting any exclusion criteria for this study will be excluded from this
        study.

          -  Has spinal cord compression or clinically active central nervous system metastases,
             defined as untreated and symptomatic, or requiring therapy with corticosteroids or
             anticonvulsants to control associated symptoms. Participants with clinically inactive
             brain metastases may be included in the study.

          -  Has leptomeningeal carcinomatosis.

          -  Has prior treatment with:

               1. Any chemotherapeutic agent targeting topoisomerase I, including antibody drug
                  conjugate (ADC) containing such agent.

               2. TROP2-targeted therapy.

          -  Uncontrolled or significant cardiovascular disease:

               1. History of myocardial infarction within 6 months prior to Cycle 1 Day 1.

               2. History of uncontrolled angina pectoris within 6 months prior to Cycle 1 Day 1.

               3. Symptomatic congestive heart failure (CHF) (New York Heart Association Class II
                  to IV) at screening. Participants with a history of Class II to IV CHF prior to
                  screening must have returned to Class I CHF and have LVEF ≥50% (by either an ECHO
                  or MUGA scan within 28 days of Cycle 1 Day 1) in order to be eligible.

               4. History of serious cardiac arrhythmia requiring treatment.

               5. LVEF <50% or institutional lower limit of normal by ECHO or MUGA scan.

               6. Uncontrolled hypertension (resting systolic blood pressure >180 mmHg or diastolic
                  blood pressure >110 mmHg).

          -  Has a history of (non-infectious) interstitial lung disease (ILD)/pneumonitis that
             required steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis
             cannot be ruled out by imaging at screening.

          -  Clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses

          -  Clinically significant corneal disease.

          -  Has other primary malignancies, except adequately resected non-melanoma skin cancer,
             curatively treated in situ disease, or other solid tumors curatively treated, with no
             evidence of disease for ≥3 years.