Abbreviated Inclusion Criteria:

          1. Subject with histological or cytological diagnosis of advanced/metastatic cancer

          2. Age 18 years or older, is willing and able to provide informed consent

          3. Evidence of measurable disease

          4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

        Abbreviated Exclusion Criteria:

          1. History of allergy or hypersensitivity to study treatment components. Subjects with a
             history of severe hypersensitivity reaction to any monoclonal antibody

          2. Use of investigational agent within 28 days prior to the first dose of study treatment
             and throughout the study

          3. Receiving high-dose systemic steroid therapy or any other form of immunosuppressive
             therapy

          4. History of severe autoimmune disease

          5. Uncontrolled intercurrent illness or other active malignancy requiring ongoing
             treatment