Inclusion Criteria:

          -  Patients with a locally advanced or metastatic malignancy, that has progressed
             following systemic therapy for their disease, if available, or for which the patient
             is not a candidate or refuses.

          -  Tumors harboring a MEK or atypical BRAF alteration.

          -  Provide signed and dated informed consent prior to initiation of any study-related
             procedures that are not considered standard of care (SoC).

          -  Male or female patients aged ≥18 years.

          -  Patients must have measurable disease by RECIST version 1.1.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2.

          -  Adequate renal function [creatinine ≤1.5 times ULN (upper limit of normal)] or a
             glomerular filtration rate (GFR) of ≥50 mL/min (using Cockcroft-Gault).

          -  Adequate hepatic function [total bilirubin ≤1.5 times ULN; AST (aspartate
             transaminase) and ALT (alanine transaminase) ≤3 times ULN or ≤5 times ULN if the
             elevation is due to liver involvement by tumor].

          -  Adequate bone marrow function (hemoglobin ≥9.0 g/dL; platelets ≥100 x 109 cells/L;
             absolute neutrophil count ≥1.5 x 109 cells/L).

          -  Adequate cardiac function: Left ventricular ejection fraction (LVEF) of >50% as
             assessed by multi-gated acquisition (MUGA) or ultrasound/echocardiography (ECHO); and
             a corrected QT interval (QTc) <480ms by the Fridericia method (QTcF).

          -  Contraception - women: Negative pregnancy test for females of child-bearing potential;
             must be surgically sterile, postmenopausal (no menstrual cycle for at least 12
             consecutive months), or compliant with a medically approved contraceptive regimen
             during and for 3 months after the last administration of study drug. Abstinence is not
             considered an adequate contraceptive regimen.

          -  Contraception - men: Must be surgically sterile, or compliant with a medically
             approved contraceptive regimen during and for 3 months after the last administration
             of study drug.

          -  Willing and able to participate in the trial and comply with all trial requirements.

          -  Patients with a prior or concurrent malignancy whose natural history or treatment does
             not have the potential to interfere with the safety or efficacy assessment of the
             investigational agent may be included after consultation with the medical monitor.

        Exclusion Criteria:

          -  Gastrointestinal (GI) condition that could impair absorption of study medication
             (specific cases e.g., remote history of GI surgery, may be enrolled after discussion
             with the medical monitor) or inability to ingest study medication.

          -  Uncontrolled or severe intercurrent medical condition.

          -  Known uncontrolled brain metastases. Stable brain metastases either treated or being
             treated with a stable dose of steroids/anticonvulsants, with no dose change in the
             previous 4 weeks, can be allowed.

          -  Having received any cancer-directed therapy (chemotherapy, hormonal therapy, biologic
             or immunotherapy, etc.) within 28 days or 5 half-lives (whichever is shorter) prior to
             the first dose of study drug. Patients previously treated with radiotherapy must have
             recovered from the acute toxicities associated with such treatment.

          -  Major surgery within 4 weeks prior to first dose.

          -  Any use of an investigational drug within 28 days or 5 half-lives (whichever is
             shorter) prior to the first dose of study drug. A minimum of 10 days between
             termination of the prior investigational drug and administration of study drug is
             required. In addition, any drug-related toxicity except alopecia should have recovered
             to Grade 1 or less.

          -  Prior therapy with any ERK inhibitor (e.g. LY3214996, LTT462).

          -  Groups 1-4: Prior therapy with any BRAF and/or MEK inhibitor (e.g. encorafenib,
             dabrafenib, vemurafenib, binimetinib, trametinib, cobimetinib) is excluded. Prior BRAF
             and/or MEK inhibitor therapy is permitted for Groups 5 and 6.

          -  For Part B, agents targeting BRAF or MEK kinases and experimental agents are not
             permitted as physician's choice

          -  Pregnant or breast-feeding women.

          -  Any evidence of serious active infections. Patients are allowed to enroll if they have
             been fever-free for at least 48 hours and are on an active treatment that is not
             prohibited in Appendix 1 of the protocol.

          -  Any important medical illness or abnormal laboratory finding that would increase the
             risk of participating in this study (based on the investigator's judgment).

          -  A history or current evidence/risk of retinal vein occlusion (RVO) or central serous
             retinopathy (CSR).

          -  Concurrent therapy with any other investigational agent.

          -  Concurrent therapy with drugs known to be strong inhibitors or inducers of CYP1A2,
             CYP2D6, and CYP3A4.