Inclusion Criteria:

          -  Has a histologically confirmed diagnosis of locally advanced/metastatic RCC with clear
             cell component

          -  Has measurable disease per RECIST 1.1 as assessed by BICR

          -  Can submit an archival tumor tissue sample or newly obtained core or excisional biopsy
             of a tumor lesion not previously irradiated

          -  Has experienced disease progression on or after systemic treatment with an
             anti-programmed cell death 1 (PD-1)/Ligand 1 (L1) therapy for locally advanced or
             metastatic RCC. The anti-PD-1/L1 therapy may be monotherapy or in combination with
             other agent(s) such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) or
             vascular endothelial growth factor (VEGF) targeted- tyrosine kinase inhibitor (TKI).
             The immediately preceding line of treatment has to have been an anti-PD-1/L1 therapy

          -  Has received no more than 3 prior systemic regimens for locally advanced or metastatic
             RCC

          -  Has received only 1 prior anti-PD-1/L1 therapy for locally advanced or metastatic RCC

          -  Has recovered from all AEs due to previous therapies to ≤Grade 1 or baseline, with the
             exception of ≤Grade 2 neuropathy or endocrine-related AEs ≤Grade 2 requiring treatment
             or hormone replacement

          -  Has a Karnofsky performance status (KPS) score of at least 70% assessed within 10 days
             prior to the first dose of study intervention

          -  A male participant is eligible to participate if he is abstinent from heterosexual
             intercourse or agrees to use contraception during the intervention period and for at
             least 7 days after the last dose of study intervention

          -  A female participant is eligible to participate if she is not pregnant, not
             breastfeeding, and at least 1 of the following conditions applies: Not a (woman of
             childbearing potential) WOCBP or a WOCBP who agrees to follow the contraceptive
             guidance during the intervention period and for at least 30 days after the last dose
             of study intervention

          -  A WOCBP must have a negative highly sensitive pregnancy test (urine or serum) within
             24 hours before the first dose of study intervention

        Exclusion Criteria:

          -  Has hypoxia (a pulse oximeter reading <92% at rest), requires intermittent
             supplemental oxygen, or requires chronic supplemental oxygen

          -  Has a known additional malignancy that is progressing or has required active treatment
             within the past 3 years except for basal cell carcinoma of the skin, squamous cell
             carcinoma of the skin, or carcinoma in situ [e.g., breast carcinoma, cervical cancer
             in situ] that have undergone potentially curative therapy

          -  Has known central nervous system (CNS) metastases and/or carcinomatous meningitis

          -  Has clinically significant cardiac disease, including unstable angina, acute
             myocardial infarction ≤6 months from Day 1 of study drug administration or New York
             Heart Association Class III or IV congestive heart failure

          -  Has moderate to severe hepatic impairment (Child-Pugh B or C)

          -  Has received colony-stimulating factors (eg, granulocyte colony-stimulating factor
             [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF], or recombinant
             erythropoietin [EPO]) ≤28 days prior to the first dose of study intervention

          -  Has a known psychiatric or substance abuse disorder that would interfere with
             cooperation with the requirements of the study

          -  Is unable to swallow orally administered medication or has a gastrointestinal disorder
             affecting absorption (eg, gastrectomy, partial bowel obstruction, malabsorption)

          -  Has known hypersensitivity or allergy to the active pharmaceutical ingredient or any
             component of the study intervention (belzutifan) formulations

          -  Has received prior treatment with belzutifan or another hypoxia-inducible factor
             (HIF)-2α inhibitor

          -  Has received any type of small molecule kinase inhibitor (including investigational
             kinase inhibitor) ≤2 weeks before randomization

          -  Has received any type of systemic anticancer antibody (including investigational
             antibody) ≤4 weeks before randomization

          -  Has received prior radiotherapy ≤2 weeks prior to first dose of study intervention.
             Participants must have recovered from all radiation-related toxicities and not require
             corticosteroids

          -  Has had major surgery ≤3 weeks prior to first dose of study intervention

          -  Is currently receiving either strong (phenobarbital, enzalutamide, phenytoin,
             rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or
             moderate (eg, bosentan, efavirenz, modafinil) inducers of cytochrome P450 (CYP)3A4
             that cannot be discontinued for the duration of the study

          -  Is currently participating in a study of an investigational agent or is currently
             using an investigational device

          -  Has an active infection requiring systemic therapy

          -  Has active tuberculosis (TB)

          -  Has a diagnosis of immunodeficiency

          -  Has a known history of human immunodeficiency virus (HIV) infection

          -  Has a known history of hepatitis B (HBV) or known active hepatitis C (HCV) infection

          -  Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the study, interfere with the participant's
             participation for the full duration of the study, or is not the best interest of the
             participant to participate, in the opinion of the treating investigator