Inclusion Criteria:

        The study is comprised of 2 main parts Monotherapy (AZD8701) and Combined Therapy (AZD8701
        and Durvalumab).

        Inclusion criteria Dose escalation stages:

          -  Histological or cytological confirmation of a solid, malignant tumour including HNSCC,
             TNBC, NSCLC, ccRCC, gastric cancer, melanoma, cervical cancer, SCLC, and/or
             participants with other solid tumours who have demonstrated a response to prior
             anti-PD-(L)1 treatment

          -  Participant with progressive disease that is refractory to standard therapies or for
             which no standard therapies exist and a clinical trial is the best option for next
             treatment based on prior response and/or tolerability to standard of care

        Inclusion Criteria Dose Expansions:

        Non Small Lung Cancer Participants who have received prior PD(L)1 treatment. Clear Cell
        Renal Cancer Participants who have not received prior PD(L)1 treatment.

        Triple negative Breast Cancer participants who have who have not received prior PD(L)1
        treatment.

        General inclusion criteria:

          -  Must be 18 year old at the time of screening

          -  Body weight > 35 kg

          -  Male and Female participants of childbearing potential must use effective methods of
             contraception

          -  Capable of giving signed informed consent

          -  ECOG performance status of 0 to 1

          -  A serum albumin > 35g/L

          -  Life expectancy of > 12 weeks

          -  At least 1 lesion, that qualifies as a RECIST 1.1 target lesion at baseline. Tumour
             assessment by CT scan or MRI must be performed within 28 days prior to treatment.

          -  Participants must provide a new or previous tumour sample

          -  Adequate organ system functions

        Exclusion Criteria:

          -  A condition that, in the opinion of the Investigator, would interfere with evaluation
             of the study intervention or interpretation of participant safety or study results

          -  History of allogeneic organ transplantation.

          -  Active or prior documented autoimmune or inflammatory disorders Uncontrolled
             intercurrent illness

          -  Significant cardiac disease

          -  History of another primary malignancy except for

               1. Malignancy treated with curative intent and with no known active disease ≥ 5
                  years

               2. non-melanoma skin cancer

               3. Adequately treated carcinoma in situ without evidence of disease.

          -  Participant with previous or confirmed Covid 19 diagnosis requiring significant
             medical intervention

          -  Current clinical signs and symptoms consistent with COVID-19 or confirmed current
             infection by appropriate laboratory test within the last 4 weeks prior to screening

          -  Any major unresolved toxicity from previous anticancer therapy

          -  Known allergy or hypersensitivity to any of the study interventions or any of the
             study intervention excipients.

        Prior/Concomitant Therapy

          -  Receipt of the last dose of anticancer therapy within 5 half-lives or ≤ 21 days prior
             to the first dose of study

          -  Prior treatment with potential Treg depletion therapies including agents targeting
             CTLA-4 for 90 days prior to enrolment on study.

          -  Participants who have received prior anti-PD-1, anti-PD-L1, or anti-CTLA-4:

               1. Must not have experienced a toxicity that led to permanent discontinuation of
                  prior immunotherapy.

               2. All AEs while receiving prior immunotherapy must have completely resolved or
                  resolved to baseline

               3. Must not have experienced a ≥ Grade 3 imAE or a neurologic or ocular imAE of any
                  grade while receiving prior immunotherapy.

               4. Must not have required the use of additional immunosuppression other than
                  corticosteroids for the management of an AE

          -  Current or prior use of immunosuppressive medication within 14 days before the first
             dose of study drug. b. The following are exceptions to this criterion:

               1. Intranasal, inhaled, topical steroids, or local steroid injections (eg,
                  intra-articular injection).

               2. Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
                  prednisone or its equivalent

               3. Steroids as premedication for hypersensitivity reactions (eg, CT scan
                  premedication)

          -  Any concurrent chemotherapy, investigational product, biologic, or hormonal therapy
             for cancer treatment

          -  Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of
             radiation within 4 weeks of the first dose of study intervention.

          -  Major surgical procedure within 28 days prior to the first dose

          -  Participants receiving anticoagulation treatment for venous or arterial indications

          -  Participation in another clinical study with study intervention administered in the
             last 30 days

          -  Female participants who are pregnant or breastfeeding or male and female participants
             of reproductive potential who are not willing to employ effective birth control