Inclusion Criteria:

          1. Must have a histologically or cytologically confirmed diagnosis of locally advanced or
             metastatic solid tumors:

               1. who have disease progression on standard therapy,

               2. who are receiving a standard anticancer treatment but no subsequent approved
                  treatment would be available upon progression,

               3. who are unable to receive standard therapy, or

               4. for whom standard therapy does not exist.

          2. Demonstrate CCR5 + by IHC (>10% of primary or metastatic tumor cells shows membranous
             staining and/or high predominance of CCR5+ tumor-infiltrating leukocytes completed at
             the reference laboratory of Dr. Hallgeir Rui at Medical College of Wisconsin).

             Note: This test will be done as part of the pre-screening period. It will be performed
             in archival metastatic tissue. If archival tissue is not available then, fresh biopsy
             will be done;

          3. Be willing to provide tissue from a newly obtained core or excisional biopsy of a
             tumor lesion (in case archival tissue is not available);

          4. Patients must have measurable disease based on RECIST v1.1;

          5. ≥ 18 years of age;

          6. Patients must exhibit a/an ECOG performance status of 0-1;

          7. Life expectancy of at least 6 months;

          8. Patients must have adequate organ and bone marrow function within 28 days prior to
             registration, as defined below:

               -  leukocytes ≥ 3,000/mcL;

               -  absolute neutrophil count ≥ 1,500/mcL;

               -  platelets ≥ 100,000/mcL;

               -  total bilirubin: within normal institutional limits;

               -  AST(SGOT) and ALT(SPGT) ≤ 2.5 X institutional upper limit of normal (ULN)
                  (applicable to all patients, irrespective of liver disease or metastasis); and

               -  creatinine: within normal institutional limits.

          9. Clinically normal resting 12-lead ECG at Screening Visit or, if abnormal, considered
             not clinically significant by the Principal Investigator.

         10. Females of child-bearing potential (FOCBP) and males must agree to use two medically
             accepted methods of contraception with hormonal or barrier method of birth control, or
             abstinence, prior to study entry, for the duration of study participation and for 60
             days after the last dose of study drug (Refer to Appendix 1). Should a female patient
             become pregnant or suspect she is pregnant while participating in this study, she
             should inform her treating physician immediately. NOTE: A FOCBP is any woman
             (regardless of sexual orientation, having undergone a tubal ligation, or remaining
             celibate by choice) who meets the following criteria:

               -  Has not undergone a hysterectomy or bilateral oophorectomy; and

               -  Has had menses at any time in the preceding 12 consecutive months (and therefore
                  has not been naturally postmenopausal for > 12 months).

         11. FOCBP must have a negative serum pregnancy test at Screening Visit and negative urine
             pregnancy test prior to receiving the first dose of study drug; and

         12. Patients must have the ability to understand and the willingness to sign a written
             informed consent prior to registration on study.

        Exclusion Criteria:

          1. Is currently participating and receiving study therapy or has participated in a study
             of an investigational agent and received study therapy or used an investigational
             device within 28 days prior to enrollment;

          2. Patients who have a history of allergic reactions attributed to compounds of similar
             chemical or biologic composition to leronlimab (PRO 140) are not eligible;

          3. Patients who have had prior exposure to CCR5 antagonists are not eligible;

          4. Has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis. Note: Subjects with previously treated brain metastases may participate
             provided they are stable (without evidence of progression by imaging for at least four
             weeks prior to the first dose of trial treatment and any neurologic symptoms have
             returned to baseline), have no evidence of new or enlarging brain metastases, and are
             not using steroids for at least 7 days prior to trial treatment. This exception does
             not include carcinomatous meningitis which is excluded regardless of clinical
             stability;

          5. Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the trial, interfere with the subject's
             participation for the full duration of the trial, or is not in the best interest of
             the subject to participate, in the opinion of the treating investigator;

          6. Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial; and

          7. Is pregnant or breastfeeding, or expecting to conceive or have children within the
             projected duration of the trial, starting with the pre-screening or screening visit
             through the duration of study participation.