Exercise has been established to be safe and result in improved physical function and quality
of life for most individuals with cancer. However, little information exists regarding
whether exercise can increase overall survival and reduce disease progression, events related
to cancer spreading to the bones (e.g. bone fracture, spinal cord compression, extra
radiation or surgery), and pain in patients with metastatic prostate cancer that is no longer
responding to hormone therapy. The primary objective of this study is to determine if high
intensity aerobic and resistance training plus psychosocial support increases overall
survival compared to psychosocial support alone in prostate cancer patients.
The Movember foundation is providing support for the conduct of this study
Exercise as Non-Pharmacologic Adjuvant Therapy for Prostate Cancer:
Identifying and evaluating low-toxicity adjuvant interventions that can be combined with
standard therapy to improve outcomes for men with prostate cancer is a high priority and has
the potential to have a large impact on the clinical and public health burden of prostate
cancer. The investigators summarise briefly below promising observational, pre-clinical, and
pilot clinical data that support the hypothesis that exercise improves overall survival and
health-related quality-of-life (QOL) among men with advanced prostate cancer:
- Vigorous aerobic exercise after diagnosis was associated with a 60% risk of fatal
prostate cancer and a 49% risk of all-cause mortality among men initially diagnosed with
localised disease.
- Loading of bone inhibited growth of metastatic tumours in animal models.
- Resistance exercise and programs with both resistance and aerobic exercise improved
physical function and quality-of-life in men without metastases on androgen deprivation
therapy (ADT) for prostate cancer.
- Treatment-related fatigue is a common side effect in men with advanced prostate cancer
and exercise may decrease fatigue and increase adherence to treatment regimens.
- New standard treatments for advanced prostate cancer cause adverse metabolic effects
(e.g., weight gain, insulin resistance) that may be avoided or attenuated by exercise.
Potential mechanisms of exercise influencing prostate cancer tumour biology
Potential mechanisms by which exercise may reduce the risk of prostate cancer progression,
the incidence and progression of comorbidities, treatment side effects, and overall death
among men with advanced prostate cancer include:
Endocrine - Exercise influences all hormonal systems in the body with key hormones relevant
to prostate cancer being testosterone, growth hormone, and insulin-like growth factor-1
(IGF-I). The androgen receptor and its transactivation by ligand are one of the most
important determinants of prostate cancer progression. Measurements of serum androgens
provide an important biomarker for effectiveness of androgen deprivation and prostate cancer
progression. Current studies are inconclusive as to the effects of exercise on serum androgen
levels. In part, these studies are limited by low patient numbers and inadequate methods for
measuring testosterone levels in the low ranges seen in men on androgen deprivation therapy.
This is especially true with the cyp17 inhibitors, such as Abiraterone.
Immune System, Inflammation, and Cytokines - High levels of inflammatory biomarkers are
associated with an increased risk of prostate cancer-specific mortality, and exercise is
known to levels of circulating inflammatory biomarkers (e.g., interleukin- 6 (IL-6)) in
elderly populations. In addition, exercise may enhance natural killer cell cytotoxicity and
immune surveillance, improving immune defence against prostate cancer. Further, adipokines
may also have pro- or anti-oncogenic roles in angiogenesis and cell proliferation. For
example, adiponectin has anti-inflammatory effects and its serum concentration is inversely
correlated with adiposity. Resistin is associated with insulin resistance through AMP kinase
down-regulation. It up-regulates pro-inflammatory cytokines (IL-6, tumour necrosis factor
alpha (TNFα)) which act via the nuclear factor kappa-light-chain-enhancer of activated B
cells (NFκb) pathway to increase transcription of proteins involved in cell proliferation,
inflammation and anti-apoptosis. In addition, activation of NFκb is implicated in prostate
cancer, nuclear expression being associated with nodal metastasis. IL-6 and TNFα are both
elevated in the serum of patients with metastatic carcinoma compared to patients without
metastases. Interestingly, both are elevated in prostate carcinoma in direct proportion to
disease stage, and increases occur at the time of biochemical (PSA) disease progression.
Energy Metabolism - Exercise improves insulin sensitivity and glucose metabolism. While ADT
in principle is targeting the prostate cancer tumour, the systemic treatment in patient's
results in a range of alterations associated with metabolic syndrome. One of the earliest
changes following ADT, within 2-6 a reduction in insulin sensitivity leading to a rise in
circulating insulin (hyperinsulinemia); the rise in insulin levels precedes changes in
adiposity and increased lipids, sarcopenia, and bone loss. High insulin levels are predictive
of more rapid progression to CRPC, and poor prognosis. Insulin has been shown to have a
direct action on prostate cancer growth and progression, and this can be inhibited by
blocking insulin action. Additionally, high levels of C-peptide, a marker of insulin
secretion, are associated with a more than 2-fold increased risk of prostate cancer-specific
mortality. Further, over the (body mass index (BMI) >25 kg/m2) men with high C-peptide levels
had a more than 4-fold increased risk of prostate cancer-specific mortality compared to
normal the men with low C-peptide levels.
Body composition - Cancer and its treatments cause substantial changes in body composition
with sarcopenic obesity being a common outcome. This not only results in substantial
impediment to functional ability and increased cardio-metabolic risk, but also alteration of
adipokine and myokine balance, which may contribute to tumour progression. Exercise increases
lean muscle mass and may cause loss of fat mass, thereby improving overall body composition.
Epigenetics - Exercise can produce epigenetic modulations that may inhibit tumour cell
proliferation, such as altering histone deacetylase pathways.
Telomere - Short and/or variable telomere length in the prostate is a prognostic marker among
men with prostate cancer. One study among 10 men with localised prostate cancer on active
surveillance reported that a lifestyle program that included moderate exercise (as the as
diet, stress management, and social support) increased telomere length in blood.
Cholesterol - Epidemiological studies have suggested that high levels of cholesterol in the
blood are associated with increased risk of prostate cancer and progression of prostate
cancer. Exercise combined with dietary modification has been demonstrated to substantially
reduce total cholesterol as the as improve the ratio of high density lipoprotein to low
density lipoprotein cholesterol.
Oxidative stress - Exercise has been demonstrated to modulate oxidative stress and improve
antioxidant capacity. In a pilot study at the University of California, San Francisco, men
with low risk, localised prostate cancer who reported ≥3 hours/the of vigorous physical
activity had modulated expression of the nuclear factor erythroid 2-related factor 2 (Nrf-2)
mediated oxidative stress response pathway in their normal prostate tissue compared to men
who did less exercise. Oxidative stress is hypothesized to play a significant role in the
initiation and progression of prostate cancer.
As the burden of disease among men with prostate cancer advances, a rapid, significant
deterioration in QOL is observed. Bone pain which is reported in up to 80% of patients with
metastatic disease throughout their treatment, makes the largest single contributor to QOL
deterioration in this population. Other symptoms which compromise QOL include urinary
frequency, sexual dysfunction, nausea and vomiting, loss of appetite and dyspnoea. The
benefits of exercise training on QOL for men with non-metastatic prostate cancer are the
described, and include improvements in general QOL and also cancer-specific concerns
including fatigue and sexual health. Whether exercise can improve QOL among men at the end
stage of this disease is not known.
Metastatic spread of prostate cancer occurs primarily to sites in the axial skeleton
including the femur, pelvis and vertebrae. Metastatic lesions, which are typically
osteoblastic, lead to significant bone pain and compromised skeletal quality. Skeletal
complications, such as bone fractures, orthopaedic intervention or spinal cord compression,
which develop due to bone metastases, result in significant patient morbidity and compromised
QOL. Furthermore, compared to those who do not experience a symptomatic skeletal related
event (SSE), the occurrence of a SSE is associated with increased patient mortality. A
modular multi-modal approach to exercise training involving individualised prescription of
exercise to reduce the forces going through the bone has been shown to be safe and feasible
in men with bony metastases and not associated with increased risk of pathological fracture.
This proposal will test whether exercise training delays time to SSE as the time to
progression of pain and affects measures of pain severity and opiate use. Control or relief
of pain and delay or prevention of SSE are both indications for approved therapeutic agents
for men with metastatic prostate cancer.
In addition to SSE and pain due to the infiltration of metastatic prostate cancer in bone,
men with this disease also experience debilitating cancer-related fatigue and adverse
cardio-metabolic health as a side effect of therapy. Cancer-related fatigue is a distinct
phenomenon from fatigue experienced by healthy individuals and significantly health-related
QOL. There are extensive data to support that exercise improves fatigue in men with a disease
burden. This proposal will be the first to examine whether exercise improves or delays onset
of cancer-related fatigue in men with metastatic prostate cancer.
Rationale for Focus on Metastatic Castrate-Resistant Prostate Cancer (MCRPC), our overarching
objective is to determine the effect of exercise on overall survival among men with advanced
prostate cancer. The investigators have chosen to restrict our study population to men with
progressive MCRPC because: 1) Men with progressive MCRPC are at high risk for death within a
time frame that can be feasibly tested in the setting of a RCT (median OS on treatment = 3242
to 3543 months). 2) With the proper use of stratification variables (treatment and study
site), it is possible to define a homogenous study population in terms of risk of death; 3)
This is the largest group of patients that can be uniformly considered to have advanced
prostate cancer and thus provides the largest patient pool for recruitment while also meeting
criteria 1 & 2; 4) while new therapies for MCRPC extend life, they also cause significant
harm to metabolic and cardiac function and health-related QOL which may be attenuated or
avoided through exercise; and 5) the investigators hypothesize that exercise will have the
largest measurable effect on OS among men with documented evidence of progressing MCRPC (in
contrast to men with stable M1 CRPC, non-castrate resistant disease, or non-metastatic
disease).
The primary endpoint for this randomised controlled trial will be overall survival (OS). OS
was chosen as the primary endpoint because it has clear biological, clinical and public
health significance and is a validated endpoint for approval of new treatments among men with
MCRPC. Additionally, OS data can be obtained with minimal loss to follow-up through review of
medical and death records. The median OS among men with MCRPC is 3242 to 3543 months. Thus,
OS is a feasible outcome to examine within the budget and timeline of the proposed study.
Inclusion Criteria:
- Patients must be mCRPC. This is defined as adenocarcinoma of the prostate with
systemic metastatic disease despite castrate levels of testosterone (<50 ng/dL) due to
orchiectomy or LHRH agonist.
Patients must have one or more of the following to be considered mCRPC
- Metastatic Disease Progression: >20% increase in the sum of diameters of measurable
lesions from the time of maximal regression or appearance of one or more new lesions.
- Bone Scan Progression: Appearance of one or more new lesions on bone scan attributable
to prostate cancer.
- PSA Progression: PSA ≥2 ng/ml that has risen serially on at least two occasions, each
at least one week apart (PSA1 < PSA2 < PSA3).
- Castrate levels of testosterone must be maintained while on study. Be on androgen
deprivation therapy (ADT) with a GnRH agonist/antagonist or prior bilateral
orchiectomy. All patients will be required to be on ADT during the study period or
have had a prior bilateral orchiectomy. Men with small cell neuroendocrine tumours or
features of small cell disease are not eligible.
- At enrolment, patients must fit into one of the following 5 categories:
1. Treatment naïve for mCRPC (have not yet started approved therapies for CRPC i.e.:
Abiraterone/Enzalutamide/Apalutamide/Docetaxel; less than 4 weeks on approved
therapies is still considered to be treatment naïve) Or
2. Receiving Abi/Enza/Apa for mCRPC AND responding or stable (PSA values must be
stable or declining after at least 4 weeks since starting Abi/Enza/Apa for mCRPC)
Or
3. Patients with PSA progression while on Abi/Enza/Apa are eligible as long as they
are asymptomatic AND there is no intent on starting chemotherapy within 6 months
Or
4. Patients treated with Docetaxel as first line therapy for mCRPC who are
asymptomatic without ANY evidence of progression Or
5. Patients may have progressed following Docetaxel first line and are now receiving
treatment with Abi/Enza/Apa. These patients must absolutely be responding or
stable (PSA values must be stable or declining after starting Abi/Enza/Apa
treatment) and have an expected life expectancy of more than 1 year.
- 4 weeks since last major surgery and fully recovered.
- No known contraindications to high intensity exercise, including, but not limited to:
brain metastases; current congestive heart failure(New York Heart Association Class
II, III or IV); serious or non-healing wound, ulcer, or bone fracture; spinal cord
compromise or instrumentation due to metastatic disease; peripheral neuropathy
INTERVAL Protocol Version 4.0, 19 April 2018 4
≥grade 3. No serious cardiovascular events within 12 months including, but not limited
to, transient ischemic attack (TIA), cerebrovascular accident (CVA), or myocardial
infarction (MI). Patients with a history of hypertension must be well-controlled (<
160/90) on anti-hypertensive therapy.
- Halabi Nomogram score <1951 (Risk Category rated as low or intermediate risk)
- Age ≥18 years
- Required Baseline Laboratory Values: ANC ≥ 1500/uL; Platelet count ≥ 100,000/uL;
Creatinine ≤ 1.5 x upper limits of normal; Bilirubin ≤ 1.5 x upper limits of normal;
AST ≤ 1.5 x upper limits of normal; Serum testosterone ≤ 50 ng/dL
- ECOG performance status 0-1
- Medical clearance by treating physician to undergo a symptom-limited cardiopulmonary
exercise test and vigorous aerobic and resistance exercise training, and able to
complete an acceptable cardiopulmonary exercise test.
- Exercise Coordination Centre (ECC) review and approval of subject's screening bone
scan / areas with bone metastases.
- Men participating in vigorous aerobic exercise for >60 min/week or structured
resistance exercise ≥2 days/week, are not eligible.
- Subject is willing and able to use technological aspects of the trial.
- The subject is fluent in the language
Exclusion Criteria:
- Previous radiographic or clinical progression (PSA progression is permitted) while on
treatment with abiraterone, enzalutamide, apalutamide, or a combination.
- Previously identified small cell neuroendocrine tumours or pure small cell carcinoma
of the prostate, based on a prior biopsy of the prostate.
- Brain metastases (brain imaging is not required)
- Previous and/or concurrent treatment with other anti-cancer treatments is permitted.
Patients are allowed to be treated with chemotherapy during the duration of the trial.
Patients who have received chemotherapy as part of initial androgen deprivation
therapy for metastatic castration sensitive disease are eligible.
- Currently receiving experimental treatment with non-approved drugs at the time of
enrolment. Patients must undergo a 28-day washout between last dose and screening
CPET.
- Poorly controlled hypertension. During screening ≥2/3 of readings must be < 160/90,
regardless of whether on a regimen of anti-hypertensive therapy or not.
If patient is currently taking hypertensive medication(s)/therapy, please indicate
medication and include in the Treatment and Concomitant Medications Log (SOM: Appendix 11).
- Current congestive heart failure (New York Heart Association Class II, III or IV)
- Recent serious cardiovascular events (within 12 months) including, but not limited to,
transient ischemic attack (TIA), cerebrovascular accident (CVA), or myocardial
infarction (MI).
- Medical condition such as uncontrolled infection or cardiac disease that, in the
opinion of the physician, would make this protocol unreasonably hazardous for the
patient.
- Patients with a currently active second malignancy other than non-melanoma skin
cancer. Patients are not considered to have a currently active malignancy if they have
completed necessary therapy and are considered by their physician to be at <30% risk
of relapse at time of assessment.
- Psychiatric illness, which would prevent the patient from giving informed consent or
adhering to the study protocol.
- Serious or non-healing wound, ulcer, or bone fracture.
- Known spinal cord compromise or instrumentation due to metastatic disease in the mCRPC
state. Radiation therapy for metastatic disease is allowed.
- Peripheral neuropathy ≥grade 3.
- Men participating in vigorous aerobic exercise for more than 60 minutes per week or
structured INTERVAL Protocol Version 4.0, 19 April 2018 15 Resistance exercise two or
more days per week (seek ECC approval before exclusion).
Experiences shortness of breath, chest discomfort, or palpitations when performing
activities of daily living (patient with these symptoms can participate in the study with
cardiologist clearance)
- Ongoing restriction of physical activity with physician documentation
- Has chest pain brought on by physical activity (patient can participate in the study
with cardiologist clearance)
- Has developed chest pain in the past month (patient can participate in the study with
cardiologist clearance)
- Moderate-to-severe bone pain (i.e., National Cancer Institute's Common Terminology
Criteria for Adverse Events grade 2-3 bone pain).
- Men who do not complete the baseline lifestyle and quality-of-life questionnaires and
3-days of diet diaries or country-specific FFQ will not be eligible
