This is a pilot study with a single arm in a single center assessing safety and efficacy of
combination therapy of TACE and ablation and durvalumab. This study will be conducted in
selected patients with intermediate stage HCC not amenable to curative therapy.
Approximately 30 patients will be enrolled and receive the following treatments:
TACE (day 1, up to twice. TACE interval will be 4～6 weeks) → Ablation (4 weeks after the last
TACE, up to twice. Ablation interval will be 4～6 weeks) → Durvalumab (at least 1 week after
the last ablation, 1500 mg Q4W, until mRECIST criteria defined radiological progression or
other discontinuation criteria were met, but no more than 1 year).
Inclusion Criteria:
- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the informed consent form (ICF) and in this
protocol. Written informed consent and any locally required authorization (eg, Health
Insurance Portability and Accountability Act in the US, European Union [EU] Data
Privacy Directive in the EU) obtained from the patient/legal representative prior to
performing any protocol-related procedures, including screening evaluations.
- Age > 18 years.
- Have a HCC diagnosis confirmed by radiology, histology, or cytology. Note: Radiologic
confirmation diagnosis is provided by the study site. Definition of radiological
confirmation: Clinical findings consistent with the diagnosis of a liver mass
measuring at least 1 cm with characteristic vascularization (intense enhancement seen
in the hepatic arterial-dominant phase and contrast washout in the late portal venous
phase) seen in either triphasic computed tomography (CT) scan or magnetic resonance
imaging (MRI).
- HCC newly diagnosed or recurrent with a history of surgery or ablation, with Barcelona
Clinic Liver Cancer (BCLC) Stage B not amenable to curative surgery or transplantation
or that the patient refuses surgery.
- At least 1 measurable intrahepatic lesion (≥1.0 cm) according to RECISTv1.1 criteria,
which is suitable for repeat assessments.
- Tumor size and number requirement: 1 nodule (5cm ≤ size ≤ 7cm); 2-3 nodules, at least
1 nodule > 3cm, and any nodule ≤ 7cm; 4-5 nodules, any nodule size ≤ 7cm;
- Tumors amenable for initial TACE treatment (Permitted modalities are DEB-TACE or
cTACE).
- Tumors were assessed with planning ultrasound and suitable for ablation (by
experienced doctor to assess and perform ablation procedure).
- Child-Pugh score class A to B7.
- Eastern Cooperative Oncology Group (ECOG) 0 or 1.
- Adequate normal organ and marrow function as defined below, Criteria 'a','b','c' and
'f' allow no transfusions, infusions, or growth factor support administered within 14
days before laboratory test: a. Haemoglobin ≤9.0 g/dL; b. Absolute neutrophil count
(ANC) ≥1.0 × 10^9 /L; c. Platelet count ≥50 × 10^9/L; d. Serum total bilirubin ≤2 ×
institutional upper limit of normal (ULN); e. AST (SGOT)/ALT (SGPT) ≤5× ULN; f.
Albumin ≥28 g/L; g. International normalized ratio ≤1.6 and prothrombin time ≤16 s; h.
Measured creatinine clearance (CL) >50 mL/min or Calculated creatinine CL>50 mL/min by
the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection
for determination of creatinine clearance: Males: Creatinine CL (mL/min)=Weight (kg) x
(140-Age) / (72 x serum creatinine), Females: Creatinine CL (mL/min)=Weight (kg) x
(140-Age) ×0.85 / (72 x serum creatinine).
- Patient is willing and able to comply with the protocol for the duration of the study
including undergoing treatment and scheduled visits and examinations including follow
up.
Exclusion Criteria:
- History or concurrent use of anticancer therapy (local regional therapy and systemic
therapy), including investigational products. Concurrent enrolment in another clinical
study, unless it is an observational (non-interventional) clinical study or during the
follow-up period of an interventional study. Patients with the recurrence from a
radical surgery or ablation are allowed. Evidence for radical surgery or ablation
should be provided with enhanced MRI/CT after at least 4 weeks after the treatment and
AFP level should also be negative in at least 4 weeks after the radical treatment;
Chinese traditional medicine with CFDA approval for anticancer use should be washout
for 14 days before enrolment.
- Known fibrolamellar HCC, sarcomatoid HCC, mixed cholangiocarcinoma and HCC, or
infiltrative-type HCC
- History of hepatic encephalopathy within past 12 months or requirement for medications
to prevent or control encephalopathy
- Ascites requiring invasive intervention (eg, paracentesis) to maintain symptomatic
control, within 4 weeks prior to enrolment
- Visible portal vein tumor thrombosis detected on baseline/eligibility imaging
- New York Heart Association Grade ≥2 congestive heart failure; or QTcF value ≥470 ms
detected by 12-lead electrocardiogram.
- History of stroke or myocardial infarction or cerebral hemorrhage within 6 months
prior to enrolment
- Significant traumatic injury or major surgical procedure (as defined by the
Investigator) within 4 weeks prior to enrolment.
- Active GI bleeding, with history of GI bleeding within 6 months, or investigator
defined with high risk of haemorrhage for esophageal varices.
- Current use of systemic anticoagulation or anti-platelet drugs.
- History of allogenic organ transplantation.
- Patients weighing ≤30 kg
- Active or prior documented autoimmune or inflammatory disorders. The following are
exceptions to this criterion: Patients with vitiligo or alopecia; Patients with
hypothyroidism (e.g., following Hashimoto syndrome) stable on hormone replacement; Any
chronic skin condition that does not require systemic therapy; Patients without active
disease in the last 5 years may be included; Patients with celiac disease controlled
by diet alone
- History of active primary immunodeficiency
- History of another primary malignancy except for: Malignancy treated with curative
intent and with no known active disease ≥5 years before the first day of study
treatment and of low potential risk for recurrence; Adequately treated non-melanoma
skin cancer without evidence of disease; Adequately treated carcinoma in situ without
evidence of disease
- Active infection including tuberculosis (clinical evaluation that includes clinical
history, physical examination and radiographic findings, and TB testing in line with
local practice).
- Uncontrolled Hepatitis B (HBV DNA >2000 IU/mL); Patients co-infected with HBV and HCV
(characterized by detectable HCV RNA, together with positive HBsAg or detectable HBV
DNA according to local laboratory standards). Anti-viral therapy is recommended
following the local guidelines. Patients with a non-viral etiology are allowed.
- Current or prior use of immunosuppressive medication within 14 days before enrolment.
The following are exceptions to this criterion:a. Intranasal, inhaled, topical
steroids, or local steroid injections (e.g., intra articular injection);b. Systemic
corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its
equivalent;c. Steroids as premedication for hypersensitivity reactions (e.g., CT scan
premedication, TACE procedure)
- Uncontrolled intercurrent illness, including but not limited to, unstable angina
pectoris, interstitial lung disease, serious chronic gastrointestinal conditions
associated with diarrhea, or psychiatric illness/social situations that would limit
compliance with study requirement, substantially increase risk of incurring AEs or
compromise the ability of the patient to give written informed consent.
- History of leptomeningeal carcinomatosis.
- Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the
exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
criteria.
- Known allergy or hypersensitivity to any of the study drugs or any of the study drug
excipients.
- Receipt of live attenuated vaccine within 30 days prior to the enrolment. Note:
Patients, if enrolled, should not receive live vaccine until 30 days after the last
dose of durvalumab.
- Female patients who are pregnant or breastfeeding or male or female patients of
reproductive potential who are not willing to employ effective birth control from
screening to 90 days after the last dose of durvalumab.
- Judgment by the Investigator that the patient should not participate in the study if
the patient is unlikely to comply with study procedures, restrictions, and
requirements
- Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
staff and/or staff at the study site)
