Inclusion Criteria:

          -  Men and women, age ≥18 and ≤65 years

          -  Pathologically confirmed DLBCL, sufficient diagnostic material should be available to
             forward to a central laboratory for gene expression profiling and pathology review.

          -  No prior treatment for DLBCL

          -  Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.

          -  International Prognostic Index (IPI) score of 2 to 5

          -  Disease Stage II to IV by the Ann Arbor Classification

          -  Adequate organ and marrow function

          -  Agreement to use highly effective forms of contraception during the study and 12
             months after the last dose of rituximab

        Exclusion Criteria:

          -  Evidence of severe or uncontrolled systemic diseases

          -  Known history of a bleeding diathesis (i.e., haemophilia, von Willebrand disease)

          -  History of stroke or intracranial haemorrhage in preceding 6 months.

          -  Known CNS lymphoma or leptomeningeal disease

          -  Known primary mediastinal lymphoma

          -  Known High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

          -  Prior history of indolent lymphoma

          -  History of or ongoing confirmed progressive multifocal leukoencephalopathy

          -  Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias,
             congestive heart failure, or myocardial infarction within 6 months of first dose of
             study drug, or any Class 3 or 4 cardiac disease as defined by the New York Heart
             Association Functional Classification

          -  Malabsorption syndrome, disease significantly affecting gastrointestinal function,
             resection of the stomach, extensive small bowel resection that is likely to affect
             absorption, symptomatic inflammatory bowel disease, partial or complete bowel
             obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass.

          -  Uncontrolled active systemic fungal, bacterial, viral, or other infection

          -  Prior anthracycline use ≥150 mg/m2

          -  Requires treatment with a strong cytochrome P450 3A4 (CYP3A4) inhibitor/inducer.

          -  Requires treatment with proton pump inhibitors (e.g., omeprazole, esomeprazole,
             lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole). Patients receiving
             proton pump inhibitors who switch to short-acting H2-receptor antagonists or antacids
             are eligible for enrolment into this study.