Inclusion Criteria:

          -  Histologically confirmed, UICC stage IV adenocarcinoma of the left-sided colon or
             rectum with metastases (metastatic colorectal cancer), primarily non-resectable,
             confirmed RAS mutations proven in the primary tumor or metastasis (KRAS ans NRAS exon
             2, 3, 4)

          -  Age ≥ 18 years on day of signing informed consent

          -  No previous chemotherapy for metastatic disease (1- 2 cycles FOLFIRI or mFOLFIRI are
             permitted before enrolment until RAS status is determined)

          -  Patients suitable for chemotherapy administration

          -  ECOG (Eastern Cooperative Oncology Group) status 0-1

          -  Consent to liquid biopsy and mutation analysis

          -  Estimated life expectancy > 3 months

          -  Presence of at least one measurable reference lesion according to the RECIST 1.1
             criteria (chest CT and abdominal CT 4 weeks or less before enrollment)

          -  Adequate bone marrow function defined as: Leukocytes 3.0 x 10 9/L with neutrophils 1.5
             x 10 9/L, Thrombocytes 100 x 10 9/L, Hemoglobin 9 g/dL

          -  Adequate hepatic function defined as: Serum bilirubin 1.5 x ULN (Upper limit of
             normal), ALAT (Alanine-aminotransferase (= SGPT = serum glutamate pyruvate
             transaminase) and ASAT (aspartate-aminotransferase (= SGOT = serum glutamate
             oxalacetate transaminase) 2.5 x ULN (Upper limit of normal) (in the presence of
             hepatic metastases, ALAT and ASAT 5 x ULN)

          -  Adequate renal function: Creatinine clearance ≥ 50 mL/min

          -  Adequate cardiac function defined as Normal ECG and echocardiogram with a left
             ventricular ejection fraction (LVEF) of 55%

          -  INR (International normalized ratio) < 1.5 and aPTT (activated Partial thromboplastin
             time) < 1.5 x ULN (patients without anticoagulation). Therapeutic anticoagulation is
             allowed if INR and aPTT have remained stable within the therapeutic range for at least
             2 weeks.

          -  Time interval of at least 6 months since last administration of any previous
             neoadjuvant/adjuvant chemotherapy or radiochemotherapy of the primary tumor in
             curative treatment intention to start of 1st line treatment

          -  Any relevant toxicities of prior treatments must have resolved to grade ≤ 1 according
             to the CTCAE (version 5), except alopecia

          -  Women of childbearing potential (WOCBP) should have a negative urine pregnancy test
             within 72 hours prior to receiving the first dose of study medication.

          -  Highly effective contraception for both male and female patients throughout the study
             and for at least 3 months after last dose of study medication administration if the
             risk of conception exists. Highly effective contraception has to be in line with the
             definition of the CTFG (Clinical Trial Facilitation Group) recommendation

          -  Signed written informed consent and capacity of understanding the informed consent

        Exclusion Criteria:

          -  Right sided mCRC

          -  Primarily resectable metastases

          -  Previous chemotherapy for the colorectal cancer with the exception of adjuvant
             treatment, completed at least 6 months before entering the study (1- 2 cycles FOLFIRI
             or mFOLFIRI are permitted before enrolment)

          -  Patients with known brain metastases

          -  Symptomatic peritoneal carcinosis

          -  Progressive disease before randomization

          -  History of acute or subacute intestinal occlusion, inflammatory bowel disease, immune
             colitis or chronic diarrhea

          -  Grade II heart failure (NYHA classification), Myocardial infarction, balloon
             angioplasty (PTCA) with or without stenting, and cerebral vascular accident/stroke
             within the past 12 months before enrollment, unstable angina pectoris, serious cardiac
             arrhythmia according to investigator's judgment requiring medication

          -  Active infection with hepatitis B or C

          -  Medical or psychological impairments associated with restricted ability to give
             consent or not allowing conduct of the study

          -  Additional cancer; Exceptions include adequately treated basal cell carcinoma of the
             skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has
             undergone potentially curative therapy without evidence of recurrence

          -  Uncontrolled hypertension

          -  Marked proteinuria (nephrotic syndrome)

          -  Arterial thromboembolism or severe hemorrhage within 6 months prior to randomization
             (with the exception of tumor bleeding before tumor resection surgery)

          -  Hemorrhagic diathesis or tendency towards thrombosis

          -  Participation in a clinical study or experimental drug treatment within 30 days prior
             to study

          -  Known hypersensitivity or allergic reaction to any of the study medications

          -  Severe, non-healing wounds, ulcers, bone fractures or an infection requiring systemic
             therapy

          -  Known history of alcohol or drug abuse

          -  Complete dihydropyrimidine dehydrogenase (DPD) deficiency (phenotype and/or genotype
             test) (Patients with partial DPD deficiency may be included in this clinical trial at
             the discretion of the investigator and should receive a reduced starting 5-FU dose)

          -  Known glucuronidation deficiency (Gilbert's syndrome) (specific screening not
             required)

          -  Absent or restricted legal capacity

          -  For female patients only: Pregnancy (absence to be confirmed by ß-HCG test) or
             lactating