Description:
The purposed of this study is to determine whether an infusion with specialized 'modified T
cells' (or CD19 chimeric antigen T cells, also called CD19 CAR T cells) that target the B
cell marker will reduce the risk of relapse after transplant.
Title
- Brief Title: A Phase I Trial of Donor- Derived 19-28z CAR T Cells Following Allogeneic Transplant for the Treatment of CD19 Malignancies
- Official Title: A Phase I Trial Evaluating the Safety of Consolidative Infusions of CD19-Specific Chimeric Antigen Receptor (CAR) T Cells Following T-cell Depleted Allogeneic Transplantation for High Risk B-cell Malignancies
Clinical Trial IDs
- ORG STUDY ID:
17-331
- NCT ID:
NCT04556266
Conditions
- Leukemia
- Lymphoma
- Lymphoma, B-Cell
Interventions
Drug | Synonyms | Arms |
---|
CAR T-Cell Infusion | | Cohort -1 |
Purpose
The purposed of this study is to determine whether an infusion with specialized 'modified T
cells' (or CD19 chimeric antigen T cells, also called CD19 CAR T cells) that target the B
cell marker will reduce the risk of relapse after transplant.
Trial Arms
Name | Type | Description | Interventions |
---|
Cohort -1 | Experimental | Cohorts of 3-6 patients each will be treated with escalating doses of consolidative modified T cells at Day 30 (+/- 5 days) post allo-HSCT
Total T-Cell Dose: 1 x 10^4 cells/kg | |
Cohort 1 | Experimental | Cohorts of 3-6 patients each will be treated with escalating doses of consolidative modified T cells at Day 30 (+/- 5 days) post allo-HSCT
Total T-Cell Dose: 1 x 10^5 cells/kg | |
Cohort II | Experimental | Cohorts of 3-6 patients each will be treated with escalating doses of consolidative modified T cells at Day 30 (+/- 5 days) post allo-HSCT
Total T-Cell Dose: 2 x 10^5 cells/kg | |
Cohort III | Experimental | Cohorts of 3-6 patients each will be treated with escalating doses of consolidative modified T cells at Day 30 (+/- 5 days) post allo-HSCT
Total T-Cell Dose: 4 x 10^5 cells/kg | |
Eligibility Criteria
Inclusion Criteria:
The following criteria must be met prior to the allogenic transplantation:
1. ALL in second remission or greater (≥ CR2)
- Please refer to section 3.0 for more discussion of ALL in CR1 versus CR2
2. CLL
1. High risk in any remission status as defined by 17p deletion or Richter's
transformation, or
2. All other patients eligible after at least 2 lines of standard or investigational
chemotherapy
3. B-NHL
1. Refractory or stable disease to last line of therapy per ICML 2014. Patients
should have at least 2 lines of prior therapy.
2. Relapsed disease in patients who are not candidates for autologous transplant
4. Patient's age is ≥ 18 and ≤ 60.
5. KPS ≥ 70%
6. Patients must have CD19 expression (by any detection method) demonstrated on their
malignant cells at the time of enrollment on the protocol.
7. Patients relapsed after prior CD19 CAR T cell or blinatumomab are eligible for
enrollment as long as CD19 expression is still prese on the malignant cells.
8. Patients who have a matched related donor willing to donate HSC for allograft and PBMC
for CAR T cell generation
9. Patients must have adequate organ function measured by:
1. Cardiac: asymptomatic or if symptomatic then LVEF at rest must be > 50%
2. Hepatic: < 3x ULN ALT and < 1.5 total serum bilirubin, unless there is congenital
benign hyperbilirubinemia.
3. Renal: serum creatinine <1.3 mg/dl or if serum creatinine is outside the normal
range, then CrCl > 60 ml/min (measured or calculated/estimated)
4. Pulmonary: asymptomatic or if symptomatic, DLCO > 50% of predicted (corrected for
hemoglobin)
5. Negative serum pregnancy test for women of child-bearing potential is required
Exclusion Criteria:
1. Active and uncontrolled infection at time of transplantation. Please note that
patients being actively treated for a viral reactivation may be enrolled on the
protocol at the discretion of the investigators.
2. Patients who have undergone a prior allogeneic or autologous stem cell transplant
within the previous six months.
3. Pregnant or breast feeding
4. HIV infection
5. Progressive disease at time of transplant
6. Patients with known autoimmune disease.
7. Patients with active or clinically significant neurological disorders, such as seizure
disorders.
Maximum Eligible Age: | 60 Years |
Minimum Eligible Age: | 18 Years |
Eligible Gender: | All |
Healthy Volunteers: | No |
Primary Outcome Measures
Measure: | Maximum tolerated dose (MTD) |
Time Frame: | 24 month |
Safety Issue: | |
Description: | To determine maximum tolerated dose (MTD) of intravenously administered allogeneic, donor-derived 19-28z CAR T cells administered following TCD allo-HSCT for patients with high-risk CD19+ malignancies |
Details
Phase: | Phase 1 |
Primary Purpose: | Interventional |
Overall Status: | Recruiting |
Lead Sponsor: | Memorial Sloan Kettering Cancer Center |
Trial Keywords
- Leukemia
- Lymphoma
- Lymphoma, B-Cell
- Chimeric Antigen Receptor (CAR) T cells
- CART cells
- high-risk B-cell malignancies
- 17-331
- Memorial Sloan Kettering Cancer Center
Last Updated
September 1, 2021