This research study is a Phase II clinical trial. Phase II clinical trials test the safety
and effectiveness of investigational drugs to learn whether the drugs work in treating a
specific disease. "Investigational" means that the drugs are being studied.
The U.S. Food and Drug Administration (FDA) has approved [1] venetoclax- obinutuzumab and [2]
acalabrutinib individually as treatment options for chronic lymphocytic leukemia (CLL) or
small lymphocytic lymphoma (SLL). However, the combination of all 3 drugs has not yet been
approved by the FDA.
- Venetoclax is a targeted therapy drug that works by blocking a protein called Bcl-2 in
cancer cells. Bcl-2 helps cancer cells survive and resist the effects of cancer
treatments. By blocking Bcl-2, venetoclax may kill cancer cells and/or make them more
open to the effects of other cancer treatments.
- Obinutuzumab is a drug that targets a protein called CD20, which is found on the surface
of B cells, the white blood cells that are affected by CLL. When obinutuzumab attaches
to CD20, it directly both destroys the B cells and makes them more "visible" to the
immune system. The immune system then attacks and destroys the cancerous B cells.
- Acalabrutinib is a small-molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a
protein inside of the cell that may be over-expressed in malignant B cells. It is
involved in the signaling pathway from the B-cell receptor. BTK inhibition caused by
taking acalabrutinib results in decreased malignant B-cell growth and survival.
On this study, participants will receive obinutuzumab and venetoclax. We will monitor for
minimal residual disease (MRD) using a test called "Adaptive ClonoSEQ" after treatment with
obinutuzumab and venetoclax. MRD is a molecular test, which can detect whether there is any
evidence of CLL/SLL in the blood or bone marrow. For participants with detectable MRD despite
treatment with obinutuzumab and venetoclax, acalabrutinib will be added with the goal of
achieving undetectable MRD. Additionally, for participants who have progressive CLL/SLL
despite venetoclax and obinutuzumab, acalabrutinib will be added.
The research study procedures include screening for eligibility, study treatment, end of
treatment visit, follow-up visits and an off-study visit.
- Participants will receive study treatment for 2 or 3 years.
- Participants will be followed for 2 years after completion of the study.
- It is expected that 40 people will take part in this research study
- Genentech is supporting this research study by providing venetoclax and obinutuzumab.
Inclusion Criteria:
- Diagnosis of CLL or SLL according to WHO criteria
- Participants must require therapy according to iwCLL 2018 guidelines
- Participants must have ≥ 2 points (high or intermediate risk disease) according to the
CLL
BALL Risk Model:
- Beta-2 microglobulin If ≥ 5 mg/L, assign 1 point
- Lactate dehydrogenase If >institutional upper limit of normal, assign 1 point
- Hemoglobin If <11 g/dL (female) or <12 g/dL (male), assign 1 point
- Time from start of last therapy If <24 months, assign 1 point, If 4 points, patient is
high risk, If 2-3 points, patient is intermediate risk, If 0-1 points, patient is low
risk
- Participants must have received prior systemic therapy for CLL
- Age over 18 years
- ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
- Participants must have adequate organ function as defined below:
- total bilirubin ≤2 × institutional upper limit of normal unless considered secondary
to Gilbert's syndrome, in which case ≤3 x ULN
- AST(SGOT)/ALT(SGPT) ≤2 × institutional upper limit of normal
- creatinine within normal institutional limits OR
- creatinine clearance ≥30 mL/min according to the Cockcroft-Gault Equation for
participants with creatinine levels above institutional normal.
- Participants must have adequate marrow function as defined below (unless clearly
due to disease under study per investigator discretion)
- absolute neutrophil count ≥1,000/mcL
- platelets ≥75,000/mcL OR
- > 20,000/mcL if thrombocytopenia is clearly due to disease under study (per
investigator discretion).
- For females of childbearing potential, a negative serum pregnancy test within 7
days of study treatment
- For female patients of childbearing potential and male patients with partners of
childbearing potential, agreement (by patient and/or partner) to use highly
effective form(s) of contraception (i.e., one that results in a low failure rate
[<1% per year] when used consistently and correctly) and to continue its use for
90 days after the last dose of acalabrutinib or venetoclax AND for 18 months
after the last dose of obinutuzumab (whichever date is later)
- The reliability of sexual abstinence should be evaluated in relation to the
duration of the clinical trial and the preferred and usual lifestyle of the
patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or
postovulation methods) and withdrawal are not acceptable methods of
contraception.
- Willingness to not donate sperm or oocytes during the entire study treatment
period and after treatment discontinuation
- Ability to understand and the willingness to sign a written informed consent
document.
Exclusion Criteria:
- Prior therapy with a BTK inhibitor (e.g. acalabrutinib) or BCL2 inhibitor (e.g.
venetoclax), with the following exception:
- Patients with undetectable MRD by flow cytometry at 10 (peripheral blood or bone
marrow) or CR from prior treatment with BCL2 inhibitor (with or without BTK inhibitor)
are eligible. Note: Patients who received prior BTK inhibitor therapy alone are not
eligible.
- Known hypersensitivity (IgE-mediated) reaction to obinutuzumab or to any of its
excipients
- Participants who are receiving any other investigational agents unless authorized by
the overall study principal investigator
- Known active histological transformation from CLL to an aggressive lymphoma (i.e.,
Richter's transformation)
- Active malignancy or systemic therapy for another malignancy within 3 years;
local/regional therapy with curative intent such as surgical resection or localized
radiation within 3 years of treatment is permitted; active prostate cancer that is
considered low-risk and appropriate for continued active surveillance strategy is
permitted.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements
- Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection
(excluding fungal infections of nail beds) at study enrollment, or any major episode
of infection requiring treatment with IV antibiotics or hospitalization (relating to
the completion of the course of antibiotics) within 2 weeks prior to Cycle 1, Day 1
- Known bleeding diathesis
- Pregnant women are excluded from this study because the study agents have potential
for teratogenic or abortifacient effects. Because there is an unknown but potential
risk for adverse events in nursing infants secondary to treatment of the mother with
the study agents, breastfeeding should be discontinued if the mother is treated with
study therapy.
- Prior major surgical procedure within 4 weeks of study, or anticipation of need for a
major surgical procedure during the course of the study
- Known CNS hemorrhage or stroke within 6 months of the study
- History of progressive multifocal leukoencephalopathy (PML)
- History of HIV infection or active hepatitis B (chronic or acute) or hepatitis C
infection
- Patients with occult or prior HBV infection (defined as positive total hepatitis
B core antibody [HBcAb] and negative HBsAg) may be included if HBV DNA is
undetectable. These patients must be willing to take appropriate anti-viral
prophylaxis as indicated and undergo monthly DNA testing.
- Patients positive for hepatitis C virus (HCV) antibody are eligible only if
polymerase chain reaction (PCR) is negative for HCV RNA
- Congestive heart failure, New York Heart Association classification III/IV
- Clinically significant history of liver disease, including viral or other hepatitis,
current alcohol abuse, or cirrhosis
- Receipt of live-virus vaccines within 28 days prior to the initiation of study
treatment or need for live-virus vaccines at any time during study treatment
- Known condition or other clinical situation that would affect oral absorption
- Psychiatric illness/social situations that would interfere with study compliance
- Receipt of therapy with strong inhibitors or inducers of CYP3A, CYP2C8, CYP2C9 and
CYP2C19, within 7 days prior to the first dose of study drug administration
- Consumption of grapefruit, grapefruit products, Seville oranges (including marmalade
containing Seville oranges), or star fruit within 3 days prior to the first dose of
study drug administration.
- Requires dual antiplatelet therapy or anticoagulation with warfarin
