-  INCLUSION CRITERIA:

          -  Participants must have histologically or cytologically confirmed:

               -  Metastatic or locally advanced, Solid tumor (Cohort 1)

        OR

        --Metastatic or locally recurrent, non-resectable Triple Negative Breast Cancer (TNBC),
        defined as ER < 10%, PR < 10% per immunohistochemistry (IHC) and HER 2 negative. HER2
        negative or unamplified breast cancer is defined as IHC 0 or 1+ or IHC 2+ with FISH average
        HER2 copy number < 4.0 signals per cell or HER2/CEP17 < 2.0 with average HER2 copy number <
        4.0 signals per cell.[89] HER2 testing must have been performed in a laboratory accredited
        by the College of American Pathology (CAP) or another accrediting entity (Cohort 2).

        OR

          -  Metastatic or locally recurrent, non-resectable p16 negative Head and Neck Squamous
             Cell Cancer (HNSCC). Oropharyngeal tumors must be negative for p16 overexpression by
             IHC per ASCO/CAP guidelines and in a CAP accredited lab.[90] All other head and neck
             malignancies do not require p16 testing (Cohort 3).

               -  Participants must have histologically or cytologically confirmed metastatic or
                  locally advanced disease. Historical reports from a CAP accredited lab are
                  acceptable.

               -  Subjects in Arms 1 and 2 may have disease that is measurable or non-measurable
                  but evaluable disease (e.g. present on bone scan, rising tumor markers,
                  non-measurable by RECIST but visible on CT scan). Participants with third space
                  fluid (for example pleural effusions) as only site of disease will not be
                  eligible. Subjects in Arm 3 must have measurable disease according to RECIST 1.1

               -  Participants must

          -  have received at least one prior systemic therapy for metastatic or locally advanced
             disease, unless there is no standard treatment available,

        OR

        --not tolerate standard first line treatment,

        OR

        --decline standard treatment after appropriate counseling has been provided.

        Note: Participants in Arm 3, Cohort 3 who have PD-L1 positive TNBC must have progressed on
        atezolizumab + nab-paclitaxel. Participants in Arm 3, Cohort 3 (p16 negative HNSCC) must
        have progressed on or been intolerant to a regimen involving a platinum drug or cetuximab
        monotherapy.

          -  Age greater than or equal to 18 years.

          -  ECOG performance status 0 or 1.

          -  Participants must have adequate organ and marrow function as defined below:

               -  Absolute neutrophil count (ANC) >1,500/mcL

               -  Platelets >100,000/mcL

               -  Hemoglobin > 9 g/dL without a blood transfusion in the 14 days prior to
                  enrollment.

               -  Total bilirubin < 1.5X upper limit of normal (ULN) OR in subjects with Gilbert s
                  Syndrome, a total bilirubin < 3.0 x ULN

               -  AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal OR in subjects
                  with known liver metastasis, AST/ALT < 3.0 X ULN

               -  An estimated creatinine clearance (CrCl) > 60 mL/min/1.73 m2 using the
                  Cockroft-Gault calculation
                  (https://www.kidney.org/professionals/KDOQI/gfr_calculatorCoc).

          -  The effects of immunotherapies on the developing human fetus are unknown. For this
             reason and because immunotherapy agents as well as other therapeutic agents used in
             this trial are known to be teratogenic, women of child-bearing potential and men must
             agree to use adequate contraception (hormonal or barrier method of birth control;
             abstinence) at the time of study entry, for the duration of study treatment and up to
             6 months after the last dose of the study drug (s). Should a woman become pregnant or
             suspect she is pregnant while she or her partner is participating in this study, she
             should inform her treating physician immediately.

          -  Participants with well-controlled HIV infection are eligible for trial as long as:

               -  On an effective anti-retroviral therapy (ART) > 4 weeks and with evidence of
                  viral suppression defined as HIV viral load < 400 copies/mL at enrollment

               -  CD4+ count > 200 cells/microL at enrollment

          -  No reported opportunistic infections within 6 months prior to enrollment except for
             the following which will be allowed:

               -  Esophageal candidiasis treated within last 6 months or currently improving with
                  antifungal treatment

               -  Oral and/or genital HSV treated within last 6 months or currently improving with
                  antiviral treatment

               -  Mycobacterium avium infection in last 6 months or that has been treated for at
                  least 1month.

          -  Immunomodulating drugs must be discontinued at least 1 weeks prior to enrollment for
             recent short course use (less than or equal to 14 days) or discontinued at least 4
             weeks prior to enrollment for long term use (> 14 days).

          -  Participants must have a received their last treatment > 4 weeks or 5 half-lives of
             the last treatment drug, whichever is shorter before starting on trial.

          -  Participants with known history of hepatitis B (HBV) infection are eligible for trial
             as long as the HBV viral load is undetectable.

          -  Patients with known history of hepatitis C (HCV) infection must have been treated and
             cured (viral load is undetectable). For participants with HCV infection who are
             currently on treatment, they are eligible if they have an undetectable or
             unquantifiable HCV RNA 12 weeks or longer after definitive treatment completion.

          -  Subjects must be able to understand and be willing to sign a written informed consent
             document.

        EXCLUSION CRITERIA:

          -  Participants who are receiving any other investigational agents.

          -  Participants with active brain metastases or central nervous system metastasis (less
             than 28 days out from definitive radiotherapy or surgery of brain metastasis) are
             excluded from this clinical trial. However, patients with treated brain metastasis are
             eligible if there is no

        magnetic resonance imaging (MRI) evidence of progression for 6 weeks after treatment is
        complete and the MRI within 28 days prior to enrollment. Participants requiring
        immunosuppressive doses of systemic corticosteroids (> 10 mg/day prednisone equivalent) for
        palliation are excluded. Patients with evidence of intratumoral or peritumoral brain
        metastasis hemorrhage on screening imaging are also excluded unless the hemorrhage of brain
        metastases is grade < 1 and has been stable on two consecutive imaging scans.

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to any of study drugs

          -  Steroid use or active autoimmune disease that might deteriorate when receiving an
             immunostimulatory agent with the exception of:

               -  Diabetes type I, eczema, vitiligo, alopecia, psoriasis, hypo- or hyperthyroid
                  disease or other mild autoimmune disorder not requiring immunosuppressive
                  treatment;

               -  Participants requiring hormone replacement with corticosteroid are eligible if
                  the steroids are administered only for the purpose of adrenal insufficiency and
                  at doses of <10 mg of prednisone or equivalent per day;

               -  Administration of steroids for other conditions through a route known to result
                  in a minimal systemic exposure (topical, intranasal, intro-ocular, or inhalation)
                  is acceptable;

               -  Participants on physiologic doses of systemic intravenous or oral corticosteroid
                  therapy (greater tahn or equal to the equivalent of prednisone 10 mg/day.

               -  The use of corticosteroids as premedication for contrast-enhanced studies which
                  is allowed prior to enrollment.

          -  Participants with a history of serious intercurrent chronic or acute illness, such as
             cardiac or pulmonary disease, hepatic disease, bleeding diathesis or recent (within 3
             months) clinically significant bleeding events or other illness considered by the
             Investigator as high risk for investigational drug treatment.

          -  History of second malignancy within 3 years of enrollment except for the following:
             adequately treated localized skin cancer, ductal carcinoma in situ, cervical carcinoma
             in situ, superficial bladder cancer or other localized malignancy which has been
             adequately treated.

          -  Receipt of any organ transplantation requiring ongoing immunosuppression including
             allogenic stem-cell transplant.

          -  Participants with bone metastases who have initiated denosumab or a bisphosphonate
             therapy within 28 days prior to enrollment. Continuation of prior therapy is allowed.

          -  Participants who have a QTcf interval > 475 msec or > 480 msec with a BBB on screening
             electrocardiogram.

          -  Participants with a personal or family history of long-QT syndrome or are on a
             concomitant drug that is known to cause significant QTc prolongation within 2 weeks or
             5 half-lives (whichever is shorter) of enrollment

          -  Participants with heart failure (New York Heart Association [NYHA] class III or IV) or
             cerebrovascular accident within one year or acute myocardial infarction within one
             year.

          -  Participants unwilling to accept blood products or blood transfusions as medically
             indicated. As there is a risk of severe bleeding with M7824, participants must be
             willing to receive blood transfusions if medically necessary for their own safety

          -  Any other condition, which would, in the opinion of the Principal Investigator
             indicated the subject is a poor candidate for the clinical trial or would jeopardize
             the subject or the integrity of the data obtained.

          -  Pregnant women are excluded from this study because study drugs potential for
             teratogenic or abortifacient effects are unknown. Because there is an unknown but
             potential risk for adverse events in nursing infants secondary to treatment of the
             mother with study drugs, breastfeeding should be discontinued if the mother is treated
             with study drugs.