Inclusion Criteria:

          -  Persons with recurrent or progressive grade 4 glioma (glioblastoma) are eligible for
             this study. Participants should have received standard first line therapy including
             radiation and temozolomide

          -  Eligible participants have tumors that show mutant or amplified EGFR. This
             determination can be made using standard of care mutation analysis panels (e.g.
             Snapshot). It is often assessed at diagnosis as part of standard of care

          -  Eligible participants must have evidence on magnetic resonance imaging (MRI) of
             progression. This may be as new or increased enhancement, or growth / increase in
             nonenhancing abnormality. Care should be taken to distinguish those with true
             progression from those with radiation related changes. Persons with changes in
             enhancement possibly due in part or in whole to late radiation effect should receive
             bevacizumab as standard of care, and defer study participation

          -  Participants may be receiving bevacizumab, and show progression while on bevacizumab.
             These participants may continue bevacizumab while on study. Persons not on bevacizumab
             but who would benefit from the anti-edema effect of bevacizumab should not enroll on
             this study but should proceed with bevacizumab alone, and defer enrollment until such
             time as they progress

          -  Visudyne is a vesicant. Participants will likely have poor veins, and will require
             repeated intravenous treatments. Participants must be willing to have placed a central
             venous access, such as a portacath

          -  Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-3. Participants
             who are ECOG 2 or 3 should ideally have been in that situation for some time, and not
             be in the midst of rapid clinical decline

          -  Medical comorbidities (excepting neurological) must be grade 2 or less if graded as
             toxicity

          -  Eligible participants may have grade 3 neurologic comorbidities (for example aphasia,
             ataxia) arising as a consequence of brain pathology

          -  Participants should be reasonably expected to be able to complete 6 weeks (1 cycle) of
             treatment on study before death or worsening of PS to 4 or 5

          -  Other anti-cancer medical treatments. Treatments in this category include chemotherapy
             and non-bevacizumab therapies. 7 days must have elapsed since discontinuation of prior
             chemotherapeutic treatments for glioma and study treatment. Participants may have had
             any number of prior treatments

          -  All participants on this study must have had prior radiation to the brain. Radiation
             must have been completed 90 days prior to first study treatment

          -  21 days must have elapsed since prior major surgery

          -  Participants already using a Novo-tumor treating fields therapy (TTF) (Optune) device
             and who wish to continue may do so

          -  All participants must sign a written informed consent

          -  The effects of study drugs used in this study on the developing human fetus are
             unknown. For this reason, female of child-bearing potential (FCBP) must have a
             negative serum or urine pregnancy test prior to starting therapy

          -  FCBP and men must agree to use adequate contraception (hormonal or barrier method of
             birth control; abstinence) prior to study entry and for the duration of study
             participation and 8 weeks after. Should a woman become pregnant or suspect she is
             pregnant while she or her partner is participating in this study, she should inform
             her treating physician immediately. Men treated or enrolled on this protocol must also
             agree to use adequate contraception prior to the study, for the duration of study
             participation. A female of childbearing potential (FCBP) is a sexually mature woman
             who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been
             naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at
             any time in the preceding 24 consecutive months

        Exclusion Criteria:

          -  Persons who are deemed to have progression on clinical grounds only (new symptoms,
             declining PS) are ineligible. In the absence of MRI change one cannot be confident
             that clinical deterioration is a direct result of tumor progression, and could be due
             to intercurrent illness

          -  Persons with edema which might be due to late radiation effect, not true progression,
             should receive bevacizumab as standard of care, and defer study participation. If
             (short-term) followup imaging shows reduction of edema and also progression of tumor,
             these persons are eligible (and should continue bevacizumab)

          -  Pregnant or breast-feeding women will not be entered on this study

          -  Participants may not have any baseline comorbidities or laboratory abnormalities which
             would be of grade 3 or worse if graded as toxicities by Common Terminology Criteria
             for Adverse Events (CTCAE) (excepting alopecia). An exception is made for neurologic
             comorbidities (e.g. ataxia, aphasia) arising as a consequence of the brain tumor;
             symptoms severe enough to warrant medical treatment as is offered on this study are by
             definition grade III

          -  Persons who in the opinion of the investigator may not be able to comply with the
             safety monitoring requirements of the study are ineligible

          -  Illness or any other circumstances (as defined by the investigator), which would
             preclude safe performance of study procedures or compromise the ability of the patient
             to consent to study

          -  Persons with hereditary porphyria are ineligible