PRIMARY OBJECTIVE:
I. Evaluate response rate of pamiparib plus low-dose temozolomide.
SECONDARY OBJECTIVES:
I. To evaluate the progression-free survival with pamiparib plus low-dose temozolomide.
II. To evaluate the safety (adverse events [AE's]) with pamiparib plus low-dose temozolomide.
TRANSLATIONAL OBJECTIVES:
I. To determine the association between plasma and tumor 2-hydroxyglutarate (2HG), fumarate,
and succinate levels and response to treatment.
II. To analyze the association of the genomic mutational signature (by whole genome
sequencing) of the tumor to treatment.
OUTLINE:
Patients receive orally (PO) twice daily (BID) on days 1-28 and temozolomide PO once daily
(QD) on days 1-7. Cycles repeat every 28 days for up to 36 months in the absence of disease
progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 4 months.
Inclusion Criteria:
- Subject has voluntarily agreed to participate by signing an informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status of =< 1
- Ability to swallow whole capsules
- Histologically confirmed metastatic or unresectable renal cell carcinoma with
morphologic features consistent with hereditary leiomyomatosis and renal cell cancer
(HLRCC). This can include tumors with overlapping morphology previously called
papillary, tubulocystic, tubulopapillary, collecting duct, or unclassified as long as
in the HLRCC- spectrum
- The presence of a documented germline fumarate hydratase (FH) alteration (mutation or
deletion). This includes pathogenic or likely pathogenic alterations but may also
include variants of unknown significance (VUS) in patients with strong personal or
family history where the clinician makes a presumed clinical diagnosis
- Progression on 1 or more lines of systemic therapies for metastatic disease.
Neo/adjuvant therapy in the absence of documented distant disease does not count as a
line of therapy
- No known intolerance of study drugs or excipients, and able to comply with study
requirements
- Absolute neutrophil count (ANC) >= 1,500 /microliter (mcL) (< 2 weeks prior to day 1)
- Platelets >= 100,000 / mcL (< 2 weeks prior to day 1)
- Hemoglobin >= 10 g/dL or >= 6.2 mmol/L without transfusion or erythropoietin (EPO)
dependency (within 2 weeks of first dose)
- Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated
creatinine (glomerular filtration rate [GFR] can also be used in place of creatinine
or creatinine clearance [CrCl]) >= 40 mL/min for participants with creatinine levels >
1.5 x institutional ULN (< 2 weeks prior to day 1)
- Creatinine clearance should be calculated using the standard Cockcroft and Gault
equation
- Total serum bilirubin =< 1.5 x ULN (total bilirubin must be < 4 x ULN for subject with
Gilbert's syndrome) (< 2 weeks prior to day 1)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 3 x ULN
OR =< 5 x ULN for participants with liver metastases (< 2 weeks prior to day 1)
- International normalized ratio (INR) or prothrombin time (PT), and activated partial
thromboplastin time (aPTT) =<1.5 x ULN unless participant is receiving anticoagulant
therapy, and then only as long as PT or PTT is within therapeutic range of intended
use of anticoagulants (< 2 weeks prior to day 1)
- Female patients of childbearing potential and female partners of male study patients
must agree to practice highly effective methods of birth control for the duration of
the study and for >= 6 months after the last dose of study drug. In addition,
non-sterile male patients must agree to practice highly effective methods of birth
control and avoid sperm donation for the duration of the study and for >= 6 months
after the last dose of study drug
- From the time of the first study-drug treatment through 180 days after the last study
drug treatment, male participants must use a condom when 1) having sex with a pregnant
woman AND 2) having sex with a woman of childbearing potential
- Male and female participants must agree not to donate sperm or eggs, respectively,
from the first study-drug treatment through 180 days after the last study drug
treatment
- Female participants must agree to not breastfeed during the study or for 180 days
after the last dose of study treatment
- If available, agreement to provide archival tumor tissue for exploratory biomarker
analyses
- Willingness to undergo a fresh tumor biopsy if deemed safe and feasible by the
investigator
Exclusion Criteria:
- Known hypersensitivity to any temozolomide (TMZ) component
- Prior treatment with a PARP inhibitor
- Received chemotherapy, biologic therapy, immunotherapy, or investigational agent
within 3 weeks (or =< 5 half-lives, whichever is shorter) prior to cycle 1/day 1
- Have any unresolved acute effects of any prior therapy of grade 2 or higher, except
for AEs not constituting a safety risk by investigator judgment
- Had a major surgical procedure (per investigator discretion) =< 4 weeks prior to cycle
1/day 1, or anticipation of need for major surgical procedure during the course of the
study
- Have other diagnosis of malignancy
- Except for surgically excised non-melanoma skin cancer, adequately treated
carcinoma in situ of the cervix, localized prostate cancer treated with curative
intent, adequately treated low-stage bladder cancer, ductal carcinoma in situ
treated surgically with curative intent, or a malignancy diagnosed > 2 years ago,
with no current evidence of disease and no therapy =< 2 years prior to day 1
- Subject who has received local radiotherapy of non-target lesions for local symptom
control within the last 4 weeks must have recovered from any adverse effects of
radiotherapy before recording baseline symptoms
- Have untreated leptomeningeal or brain metastasis. Subject with previously treated
brain metastases is eligible if the metastases have shown no progression on brain
computed tomography (CT) or magnetic resonance imaging (MRI) over at least 4 weeks,
the subject has no symptoms due to the brain metastases, and the subject has been off
corticosteroids for >= 2 weeks
- Have active infection requiring systemic treatment
- Have known human immunodeficiency virus (HIV) infection
- No known chronic active liver disease or evidence of acute or chronic hepatitis B
virus (HBV) or hepatitis C (HCV) infection. Patients with prior curative treatment of
hepatitis C virus are allowed if treated > 2 weeks prior to treatment previously and
HCV ribonucleic acid (RNA) undetectable by established laboratory values
- Have any of the following cardiovascular criteria:
- Current evidence of cardiac ischemia
- Current symptomatic pulmonary embolism
- Acute myocardial infarction =< 6 months prior to cycle 1/ day 1
- Heart failure of New York Heart Association classification III or IV =< 6 months
prior to cycle 1/ day 1
- Grade >= 2 ventricular arrhythmia =< 6 months prior to cycle 1/ day 1
- Cerebral vascular accident (CVA) =< 6 months prior to cycle 1/ day 1
- Have an active inflammatory gastrointestinal disease, chronic diarrhea, known
diverticular disease or had previous complete gastric resection or lap band surgery
- Gastroesophageal reflux disease under treatment with proton pump inhibitors is
allowed (assuming no drug interaction potential)
- Use or have anticipated need for food or drugs known to be strong or moderate
cytochrome P450 (CYP)3A inhibitors or strong CYP3A inducers =< 10 days (or =< 5
half-lives, whichever is shorter) prior to day 1
- Are pregnant or nursing (females of childbearing potential require a negative serum
pregnancy test =< 7 days before day 1)
- Requirement for intravenous (IV) alimentation (at the time of randomization)
- Known history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)
- Participants must not have received colony stimulating factors (e.g., granulocyte
colony-stimulating factor, granulocyte macrophage colony stimulating factor, or
recombinant erythropoietin) within 4 weeks prior initiating protocol therapy
