Inclusion Criteria:

          -  Confirmed histologic diagnosis of Non-Small-Cell Lung Carcinoma confirmation.

          -  Have received a single line of systemic therapy that included CPI and chemotherapy
             with documented radiographic disease progression on or following this single line of
             systemic therapy.

          -  LVEF > 45%, NYHA Class 1; cardiac stress test required

          -  FEV1>50% or FEV1/FVC>0.7 (6 min walk test if unable to perform or unreliable
             spirometry).

          -  At least 1 resectable lesion.

          -  Previously irradiated lesion must have radiographic progression prior to harvest.

          -  Must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1,
             and an estimated life expectancy of ≥ 6 months

          -  Patients of childbearing potential or those with partners of childbearing potential
             must be willing to practice an approved method of highly effective birth control
             during treatment and for 12 months after receiving all protocol-related therapy.

        Exclusion Criteria:

          -  Patients who have known oncogene driver mutations (eg, EGFR, ALK, ROS) which are
             sensitive to targeted therapies.

          -  Patients who have symptomatic and/or untreated brain metastases.

          -  Patients who have organ allograft or prior cell transfer within the past 20 years.

          -  Patients who are on systemic steroid therapy ≥ 10 mg/day of prednisone or other
             steroid equivalent. Patients receiving steroids as replacement therapy for
             adrenocortical insufficiency at ≤ 10 mg/day of prednisone or other steroid equivalent
             may be eligible.

          -  Patients who have any form of primary immunodeficiency

          -  Patients who have received a live or attenuated vaccination within 28 days prior to
             the start of treatment

          -  Patients who have had another primary malignancy within the previous 3 years

          -  Participation in another interventional clinical study within 21 days of the
             initiation of treatment.