Inclusion Criteria:

          1. Diagnosis of one of the following by treatment regimen:

             Regimen A (FT538 monotherapy in r/r AML)

               -  Primary refractory AML, or

               -  Relapsed AML, defined as not in CR after one or more re-induction attempts; if
                  >60 years of age, prior re-induction therapy is not required

             Regimens B or C (FT538 + mAb in r/r MM)

               -  Regimen B only: MM that has relapsed or progressed after at least two lines of
                  therapies, including a proteasome inhibitor and an immunomodulatory drug

               -  Regimen C only: MM that has relapsed or progressed after proteasome inhibitor
                  therapy, and immunomodulatory therapy

               -  Regimen B and Regimen C: Measurable disease as defined in the protocol

          2. Capable of giving signed informed consent

          3. Age ≥18 years old

          4. Agreement to comply with study procedures as described in the Schedule of Activities

          5. Contraceptive use as described in the protocol

        Exclusion Criteria:

          1. Females who are pregnant or breastfeeding

          2. ECOG Performance Status ≥ 2

          3. Evidence of insufficient hematologic function as defined in the protocol

          4. Evidence of insufficient organ function defined as defined by the protocol

          5. Clinically significant cardiovascular disease as defined by the protocol

          6. Known active central nervous system (CNS) involvement by malignancy

          7. Non-malignant CNS disease such as stroke, epilepsy, CNS vasculitis, or
             neurodegenerative disease or receipt of medications for these conditions in the 2-year
             period leading up to study enrollment

          8. Currently receiving or likely to require systemic immunosuppressive therapy for any
             reason during the treatment period

          9. Clinically significant infections including HIV, HBV and HCV

         10. Live vaccine <6 weeks prior to start of lympho-conditioning

         11. Receipt of an allograft organ transplant

         12. Prior allogeneic HSCT or allogeneic CAR-T within 6 months of Day 1, or ongoing
             requirement for systemic graft-versus-host therapy

         13. Known allergy to albumin (human) or DMSO

         14. Presence of any medical or social issues that are likely to interfere with study
             conduct or may cause increased risk to subject

         15. Any medical condition or clinical laboratory abnormality that per investigator or
             Medical Monitor judgement precludes safe participation in and completion of the study,
             or which could affect compliance with protocol conduct or interpretation of results

             Exclusion Criteria Specific to Regimen A (r/r AML)

         16. Diagnosis of promyelocytic leukemia with t(15;17) translocation

         17. Receipt of any biological therapy, chemotherapy, or radiation therapy, except for
             palliative purposes, within 2 weeks prior to Day 1 or five half-lives, whichever is
             shorter; or any investigational therapy within 28 days prior to Day 1

             Exclusion Criteria Specific to Regimens B and C (r/r MM)

         18. Plasma cell leukemia defined as a plasma cell count >2000/mm3

         19. Leptomeningeal involvement of MM

         20. Receipt of any biological therapy, chemotherapy, or radiation therapy, except for
             palliative purposes, within 2 weeks prior to Day 1 or five half-lives, whichever is
             shorter; or any investigational therapy within 28 days prior to the first dose of mAb

         21. Allergy or hypersensitivity to antibodies or antibody-related proteins