Inclusion Criteria:

          -  Historical grade II and III gliomas IDH wildtype gliomas by including; diffuse
             astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma,
             oligoastrocytoma, anaplastic oligoastrocytoma

          -  IDH wildtype gliomas (molecularly defined high grade glioma or molecularly defined
             glioblastoma [GBM])

          -  History & physical exam, and Karnofsky performance status (KFS) of >= 70 within 30
             days prior to enrollment

          -  Post-operative magnetic resonance imaging (MRI) with contrast is mandatory and
             necessary for radiation therapy (RT) planning

          -  Thin-slice (< 1.5 mm) three-dimensional (3D) T1 pre and post contrast and axial
             T2/fluid-attenuated inversion recovery (FLAIR) sequences for planning purposes are
             highly encouraged to obtain.

          -  Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 (within 60 days prior to
             registration)

          -  Platelets >= 100,000 cells/mm^3 (within 60 days prior to registration)

          -  Hemoglobin >= 10.0 g/dl (within 60 days prior to registration) (Note: The use of
             transfusion or other intervention to achieve hemoglobin [Hgb] >= 10.0 g/dl is
             acceptable)

          -  Bilirubin =< 1.5 upper limit of normal (ULN) (within 60 days prior to registration)

          -  Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN (within
             60 days prior to registration)

          -  Blood urea nitrogen (BUN) < 30 mg/dl (within 60 days prior to registration)

          -  Serum creatinine < 1.5 mg/dl (within 60 days prior to registration)

        Exclusion Criteria:

          -  Definitive clinical or radiologic evidence of metastatic disease; if applicable

          -  Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
             for a minimum of 3 years. (For example, carcinoma in situ of the breast, oral cavity
             or cervix are permissible)

          -  Prior cranial radiotherapy or radiotherapy to the head and neck where potential field
             overlaps would exist

          -  Prior chemotherapy or radiotherapy for any brain tumor

          -  Histologic diagnosis of gliosarcoma World Health Organization (WHO grade IV) or
             pilocytic astrocytoma (WHO grade I)

          -  Multicentric glioblastoma

          -  Leptomeningeal disease

          -  Inability to undergo MRI with and without contrast

          -  Severe, active co-morbidity defined as follows:

               -  Unstable angina or congestive heart failure requiring hospitalization within 6
                  months prior to enrollment

               -  Transmural myocardial infarction within the last 6 months prior to registration.
                  Evidence of recent myocardial infarction or ischemia by the findings of S-T
                  elevations of >= 2 mm using the analysis of an electrocardiogram (EKG) performed
                  within 28 days prior to registration. (Note: EKG to be performed only if clinical
                  suspicion of cardiac issue)

                  • New York Heart Association grade II or greater congestive heart failure
                  requiring hospitalization within 12 months prior to registration

               -  Serious and inadequately controlled arrhythmia at step 2 registration

               -  Serious or non-healing wound, ulcer or bone fracture or history of abdominal
                  fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy
                  or significant traumatic injury within 28 days prior to registration, with the
                  exception of the craniotomy for surgical resection

               -  Acute bacterial or fungal infection requiring intravenous antibiotics at the time
                  of registration

               -  Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects;
                  note, however, that laboratory tests for coagulation parameters are not required
                  for entry into this protocol

               -  Chronic obstructive pulmonary disease exacerbation or other respiratory illness
                  requiring hospitalization or precluding study therapy at the time of registration

               -  Human immunodeficiency virus (HIV) positive with CD4 count < 200
                  cells/microliter. Acquired immune deficiency syndrome (AIDS) based upon current
                  Centers for Disease Control and Prevention (CDC) definition; note, however, that
                  HIV testing is not required for entry into this protocol. The need to exclude
                  patients with AIDS from this protocol is because the treatments involved in this
                  protocol may be significantly immunosuppressive with potentially fatal outcomes
                  in patients already immunosuppressed

          -  Any other severe immunocompromised condition

          -  Active connective tissue disorders, such as lupus or scleroderma that in the opinion
             of the treating physician may put the patient at high risk for radiation toxicity

          -  End-stage renal disease (i.e., on dialysis or dialysis has been recommended)

          -  Any other major medical illnesses or psychiatric treatments that in the investigator's
             opinion will prevent administration or completion of protocol therapy