Inclusion Criteria:

          1. Subjects with histologically or cytologically confirmed advanced/metastatic or
             surgically unresectable cholangiocarcinoma, hepatocellular carcinoma, or other solid
             malignancy with one or more qualifying liver metastases who are refractory to standard
             therapy

               -  Have at least one liver tumor or metastasis (≤ 5 cm in size) that is not
                  sub-capsular and not near any major blood vessel

               -  Have no more than 7 liver lesions

               -  Is deemed safe for percutaneous intra-tumoral injection by local radiologist

          2. Measurable disease per RECIST v 1.1 (primary or metastatic disease)

          3. ECOG performance status or 0 - 1

          4. Life expectancy of at least 3 months

          5. Age ≥ 18 years

          6. Signed, written Institutional Review Board (IRB) approved informed consent

          7. A negative serum pregnancy test (for nonsterile women of child-bearing potential)

          8. Baseline Q-T corrected interval (QTc) interval of ≤ 480 msec using Frederica's formula

          9. Acceptable liver function:

               -  Bilirubin ≤ 1.5 times upper limit of normal

               -  AST (SGOT), ALT (SGPT) and Alkaline phosphatase ≤ 5 times upper limit of normal
                  because of cancer or metastases to the liver

         10. Acceptable renal function, defined as:

             o Serum creatinine ≤ 1.5 ULN or Creatinine Clearance ≥ 30 mL/minute

         11. Acceptable hematologic status:

               -  Hemoglobin ≥ 8 g/dL (a transfusion is allowed if Hemoglobin stays stable
                  thereafter)

               -  Absolute neutrophil count (ANC) ≥ 1,000 cells/mm3

               -  Platelet count ≥100,000 plt/mm3 x 109/ L (≥ 65,000 if low platelet counts are due
                  to splenic sequestration and portal hypertension)

         12. Urinalysis with no clinically significant abnormalities

         13. Acceptable coagulation status with partial thromboplastin time (PTT) and International
             Normalized Ratio (INR) ≤1.5 times upper limit of normal

         14. Subject has adequate vitamin D level, as defined by serum total 25-Hydroxyvitamin D
             [25(OH)D] ≥ 20 to < 60 ng/mL

         15. Completion of all previous treatments (including surgery, systemic chemotherapy and
             radiotherapy), as well as supportive care (including transfusion of blood, blood
             components and granulocyte colony-stimulation factor [G-CSF] treatment) at least 3
             weeks before screening (6 weeks for nitrosoureas or mitomycin C), with no signs or
             symptoms of acute toxicity > Grade 1 (except alopecia)

         16. For men and women of child-producing potential, the use of effective contraceptive
             methods during the study

         17. No aspirin for ≥ 5 days in advance of intra-tumoral administration, as well as
             discontinuation of antiplatelet and anticoagulant medications for the appropriate
             amount of time

        Exclusion Criteria:

          1. New York Heart Association Class III or IV cardiac disease, or myocardial infarction,
             severe unstable angina, coronary/peripheral artery bypass graft, congestive heart
             failure within the past 6 months

          2. Known active, uncontrolled infection with HIV or hepatitis B; patients with hepatitis
             B allowed if on anti-viral therapy and have a viral load ≤ 500 IU; patients with a
             history of HIV must be on antiretroviral therapy for at least four weeks and have an
             HIV viral load ≤ 400 copies/mL, have CD4+ T cell counts ≥ 350 cells/uL and no history
             of AIDS-defining opportunistic infections within 3 months prior to treatment

          3. Hepatocellular carcinoma patients with a Child Pugh score > B7

          4. Had paracentesis in the last 3 months; presence of ascites must be controlled by
             diuretics

          5. History of hepatic encephalopathy in the last 6 months

          6. History of variceal bleeding in the last 6 months

          7. Concomitant medications that are strong inhibitors or inducers of CYP450 enzymes that
             cannot be stopped or replaced during the study

          8. Major surgical procedure within 4 weeks prior to initiation of study treatment, or
             anticipation of need for a major surgical procedure during the course of the study.
             (Note: Placement of a central venous access catheter(s) (e.g., port or similar) is not
             considered a major surgical procedure.)

          9. Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic
             therapy

         10. Pregnant or nursing women. NOTE: Women of child-bearing potential and men must agree
             to use adequate contraception (hormonal or barrier method of birth control; or
             abstinence) prior to study entry and for the duration of study participation. Should a
             woman become pregnant or suspect she is pregnant while participating in this study,
             she should inform her treating physician immediately.

         11. Participation in a clinical study involving administration of an investigational
             compound within the past 30 days prior to study entry.

         12. Previous intratumoral injection within the past 30 days prior to study entry.

         13. Unwillingness or inability to comply with procedures required in this protocol

         14. Known allergy or hypersensitivity to the study drug(s) or one of the ingredients in
             the formulation

         15. Existence of any surgical, medical or laboratory condition that, in the judgment of
             the clinical investigator, might interfere with the safety, distribution, metabolism
             or excretion of the drug