Inclusion Criteria (Key Factors):

          1. Has pathologically confirmed advanced or metastatic malignancy characterized by one or
             more of the following:

               -  Participant is intolerant of existing therapy(ies) known to provide clinical
                  benefit for their condition

               -  Malignancy is refractory to existing therapy(ies) known to potentially provide
                  clinical benefit

               -  Malignancy has progressed on standard therapy

          2. Has evaluable or measurable tumor(s) in dose-escalation by standard radiological
             and/or laboratory assessments as applicable to their malignancy.

          3. Has adequate performance status (PS): Eastern Co-operative Oncology Group (ECOG).

          4. Is age ≥ 18 years.

        Exclusion Criteria (Key Factors):

          1. Participants receiving cancer therapy at the time of enrollment.

          2. Any clinically significant disease or condition affecting a major organ system.

          3. Significant cardiovascular disease or electrocardiogram (ECG) abnormalities.

          4. Known Gilbert's disease.

          5. Has had a previous (within 2 years) or has a current malignancy other than the target
             cancer.