Inclusion Criteria:

          1. Written informed consent must be obtained prior to any clinical trial procedures

          2. Aged 18 years or over.

          3. Must have a pathologically documented solid tumor(s) that has relapsed from, or is
             refractory to standard treatment, or unable to tolerate toxicities from the
             SOC/available treatments, or for which no standard treatment is available.

          4. Must have at least one measurable lesion as defined by RECISTv1.1 criteria for solid
             tumors.

          5. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

          6. Life expectancy ≥3 months (as judged by the Investigator).

          7. Must have adequate hematologic function (no blood transfusion and growth factor
             support for ≥14 days), adequate hepatic and renal function, and some key lab test
             results meeting the following laboratory values within 7 (+/-2) days before first
             dosing.

          8. Must have the willingness and ability to comply with scheduled visits, treatment
             plans, laboratory tests and other study procedures.

        Exclusion Criteria:

          1. Have biological, chemotherapy, immunotherapy or radiotherapy less than 4 weeks prior
             to starting the study treatment.

          2. Have undergone or plan to have major surgery (except for tumor biopsy) or experienced
             severe trauma ≤28 days prior to starting the study treatment.

          3. Have active central nervous system lesion (i.e., imaging instability and
             neurologically unstable). Note: patients who have received stereotactic radiotherapy
             or surgical treatment for brain tumor can be included after 3 months of procedure
             without symptoms.

          4. Previous or history of second malignancy within 3 years prior to study treatment
             except for curatively treated.

          5. Prior therapy with MEK-inhibitor with severe toxicity causing permanent damage from
             it, such as ocular, cardiac, pulmonary, etc. disorders and illness.

          6. History of any of the following within 6 months prior to Screening:

               -  Myocardial infarction.

               -  Unstable angina.

               -  Coronary artery bypass graft.

               -  Coronary angioplasty or stenting.

               -  Chronic heart failure (New York Heart Association Grade ≥2).

               -  Ventricular arrhythmias requiring continuous therapy.

               -  Supraventricular arrhythmias, including atrial fibrillation, which are
                  uncontrolled.

               -  Uncontrolled hypertension despite optimal medication management (per
                  Investigator's assessment)

               -  Cerebrovascular accidents including transient ischemic attack, or pulmonary
                  embolism.

               -  Creatine Phosphokinase (CPK) >2.5×ULN due to underlying cardiac disorders or
                  myocardial infarction.

          7. Mean resting QT calculated using Bazzetts formula (QTcB) ≥480 obtained from three
             electrocardiograms (ECGs); or family or personal history of long or short QT syndrome;
             Brugada syndrome or known history of QTc prolongation or Torsade de Pointes within 12
             months of Screening.

          8. Left ventricular ejection fraction (LVEF) <50%.

          9. History or current evidence of retinal diseases (e.g., retinal vein occlusion [RVO] or
             retinal pigment epithelial detachment, macular degeneration, and retinal detachment).

         10. Active/chronic infection with hepatitis C (note: patients positive for anti hepatitis
             C virus [HCV] antibody will be eligible if they are negative for HCV-ribonucleic acid
             [HCV-RNA]); or active hepatitis B, or active/chronic infection with human
             immunodeficiency virus (HIV).

         11. Known active tuberculosis.

         12. Infectious diseases requiring systemic treatment including patients tested positive
             for COVID-19 according to investigator site/institution's COVID-19 management policies
             and guidelines.

         13. History of allogeneic bone marrow transplantation or organ transplantation.

         14. Interstitial lung disease or interstitial pneumonitis, including clinically
             significant radiation pneumonitis (i.e., affecting activities of daily living or
             requiring therapeutic intervention). Patients with subclinical pneumonitis who have
             received immunotherapy previously can be included if his/her condition is stable
             without any medical intervention.

         15. Known hypersensitivity to IP ingredients or their analogues.

         16. Unable to swallow IP or has refractory nausea and vomiting, malabsorption, external
             biliary diversion, or any significant small bowel resection that may interfere with
             adequate absorption of IP.

         17. Concomitant medication which are strong inducers or strong inhibitors of cytochrome
             P450 CYP2C9, CYP2C19, CYP 3A4.

         18. Pregnant or breast-feeding females.

         19. Female patients of child-bearing potential or male patients who will not use an
             effective form of contraception for the duration of the study (until at least 30 days
             after the last dose of study medication).