This is a phase Ⅰ, first-in-human, open-label, dose escalation study to evaluate the safety
and tolerability, PK, immunogenicity and preliminary anti-tumor activity of LM-102 injection
in subjects with CLDN18.2-positive advanced solid tumors.
This is a phase Ⅰ, first-in-human, open-label, dose escalation study to evaluate the safety
and tolerability, PK, immunogenicity and preliminary anti-tumor activity of LM-102 injection
in subjects with CLDN18.2-positive advanced solid tumors.
Dose Escalation Traditional '3+3' escalation design will be used. Dose escalation consists of
five ascending dose levels of LM-102 (3 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg and 40 mg/kg).
All subjects will be administered every 3 weeks (1 cycle=21 days) with a dose of LM-102 as a
2 h (120±10 min) intravenous (IV) infusion until the disease progression, intolerance,
subject discontinuation/informed consent withdrawal, or at the discretion of the investigator
in consultation with sponsor.
After all the subjects in each cohort complete the DLT assessment, the safety monitor
committee (SMC) will make decisions for dose escalations, exploring intermediate/higher doses
or terminating dose escalations according to the safety, tolerability, PK and immunogenicity
data. The SMC may also adjust the dosage, frequency of administration, PK sample collection
plan, etc.
Based upon safety, tolerability, PK, and immunogenicity, the MTD or OBD will be determined by
SMC. And the RP2D will be determined based on DLTs, MTD or OBD, and the totality of the
safety data throughout the study, including dose modifications and delays, PK, and
immunogenicity data, etc.
The study will consist of 3 periods:
1. Screening period (up to 28 days before the first dose);
2. Treatment period;
3. Follow-up period [28 (±3) days after end of treatment (EOT)/early withdrawal or before
other anti-tumor treatments (whichever occurs earlier)].
Safety, tolerability and anti-tumor activity evaluation of LM-102 will be conducted
throughout the study.
Inclusion Criteria:
- 1. Subjects who are fully informed of the purpose, nature, method and possible adverse
reactions of the study, and are willing to participate in the study and sign the
informed consent document prior to any procedure; 2. Aged between 18 to 75 years old,
male or female when sign the informed consent form (ICF); 3. Subjects must have
histological or cytological confirmation of recurrent or refractory CLDN18.2-positive
advanced solid tumors including but not limit to gastric and gastroesophageal junction
adenocarcinoma, pancreatic carcinoma, biliary tract carcinoma, colorectal carcinoma,
ovarian carcinoma; 4. Subjects are intolerable for available standard therapy or there
is no standard available therapy; 5. Eastern Cooperative Oncology Group (ECOG)
performance status of 0-1 with no deterioration within 2 weeks from the first dose; 6.
Life expectancy ≥ 3 months; 7. Tumor samples have CLDN18.2 membranous staining in ≥ 1%
of the tumor cells with any intensity as determined by central immunohistochemistry
(IHC) testing. As such, all patients must be able to provide formalin fixed and
paraffin embedded archived tumor tissue samples obtained ≤ 3 years prior to screening;
8. Subjects must have the following organ and marrow function in laboratory tests
within 7 days from the first dose:
1. PLT ≥ 90 × 109/L; ANC ≥ 1.5 × 109/L; Hemoglobin ≥ 9 g/dL, without receiving EPO,
G-CSF, or GM-CSF within 14 days and blood transfusion in at least 7 days;
2. Coagulation function: INR ≤ 1.5; APTT ≤ 1.5 × ULN;
3. Liver function: Bilirubin ≤ 1.5 × ULN (Subjects with Gilbert's Syndrome are
allowed if direct bilirubin is within normal limits); AST and ALT≤ 2.5 × ULN
without liver metastases (≤ 5 × ULN if liver metastases are present); Albumin ≥
2.5 g/dL;
4. Kidney function: Serum creatinine ≤ 1.5 × ULN, or creatinine clearance ≥ 50
mL/min (using Cockcroft-Gault formula, see Appendix 2); Qualitative urine protein
≤ 1+ or qualitative urine protein ≥ 2+, but 24-hour urine protein < 1g;
5. Cardiac function: Left ventricular ejection fraction (LVEF) ≥ 50%, QT interval
(QTcF) ≤ 470 ms.
9. Subjects who are able to well communicate with investigators as well as
understand and adhere to the requirements of this study.
Exclusion Criteria:
1. Subjects who have difficulties in venous blood collection or history of
dizziness with blood or needles;
2. Childbearing potential female (see Appendix 3 Contraceptive Methods) who
have positive pregnancy test or are breast feeding;
3. Subjects who known to be allergic to LM-102 or any of its excipients;
4. Exposure to any IMP, or participate in any other clinical trial within 28
days prior to 1st dosing LM-102;
5. Subjects with prior anti-tumor within 28 days prior to 1st dosing of LM-102,
including radiotherapy (except palliative radiotherapy, beyond 14 days prior
to 1st dosing of LM-102, and the toxicity has been recovered as assessed by
investigator.), chemotherapy, biotherapy, endocrine therapy and
immunotherapy, etc. However, the application of other small molecular
targeted drugs and the herbal medicine with anti-tumor indication longer
than 14 days or 5 half-life periods of the drug (whichever is longer) is
acceptable;
6. Subjects who have received surgical or interventional treatment within 28
days prior to 1st dosing LM-102, excluding operations or surgeries that can
be recovered within 14 days prior to 1st dosing LM-102, and have been
recovered by the investigator's assessment, e.g., tumor biopsy, puncture,
palliative operation, rectal/gastrostomy, etc.;
7. Subjects who have concurrent administration of anticoagulation agents or
vitamin K antagonists;
8. Subjects who have concurrent administration of therapeutic doses of heparin
(prophylactic doses are acceptable);
9. Subjects who have gastric outlet obstruction, persistent recurrent vomiting
or uncontrolled/significant gastrointestinal hemorrhage, symptomatic peptic
ulcer, or major bleeding risk in other parts of the body within 28 days
prior to 1st dosing LM-102;
10. Central nervous system metastasis or meningeal metastasis with clinical
symptoms, or other evidence that the subject's central nervous system
metastasis or meningeal metastasis has not been controlled, and the
investigator judges it to be unsuitable for inclusion;
11. Subjects who have symptomatic congestive heart failure, history of
congestive heart failure greater than New York Heart Association (NYHA)
Class II, unstable angina pectoris, uncontrolled hypertension (Blood
pressure still ≥ 140/90 mmHg after drug treatment), clinically significant
cardiac arrhythmia or myocardial infarction within the past 6 months, etc.;
12. Any adverse events from prior anti-tumor therapy have not yet recovered to ≤
grade 1 of CTCAE v5.0 (Except for some grade 2 toxicity that the
investigator judges that there is no safety risk, such as alopecia, and
other long term ≤ grade 2 toxicities which would not impact the
administration of LM-102 and safety evaluation);
13. Subjects who have uncontrolled or severe illness, including but not limited
to ongoing or active infection requiring antibiotics;
14. Subjects who have a history of immunodeficiency disease, including other
acquired or congenital immunodeficiency diseases, or organ transplantation,
or allogeneic bone marrow transplantation, or autologous hematopoietic stem
cell transplantation;
15. HIV infection, active HBV infection (HBV DNA exceeds the ULN), active HCV
infection (HCV RNA exceeds the ULN);
16. Male and female subjects who are unwilling to use adequate contraceptive
methods (e.g, concomitant use of a spermicidal agent, barrier contraceptive,
or/and intrauterine contraceptive during the study and for at least 6 months
after the last dose of LM-102. (See Appendix 3 for contraceptive methods);
17. Subjects who have psychiatric illness or social situations that would
preclude study compliance;
18. Subjects who have another active malignancy which is likely to require
treatment;
19. Subject who is determined as not eligible to participate in this study by
the investigator.