Inclusion Criteria:

          -  Patients with advanced or metastatic non-neurological solid tumors, who have
             progressed on standard therapy or cannot tolerate standard therapy, or for whom there
             is no standard therapy preferred to enrollment in a clinical study

          -  All patients must consent to provide archival tumor biopsy samples within 12 months,
             or a fresh tumor biopsy is needed. Patients must also consent to provide on treatment
             biopsies as per protocol

          -  At least one measurable tumor ≥ 1 cm in longest diameter (or shortest diameter for
             lymph nodes)

          -  At least one injectable tumor ≥ 1 cm in longest diameter or injectable tumors which in
             aggregate are ≥ 1 cm in longest diameter (or shortest diameter for lymph nodes

          -  Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

        Exclusion Criteria:

          -  Prior treatment with an oncolytic therapy

          -  History of viral infections according to the protocol

          -  Systemic infection requiring intravenous (IV) antibiotics

          -  Active significant herpetic infections or prior complications of HSV-1 infection
             (e.g., herpetic keratitis or encephalitis)

          -  Requires intermittent or chronic use of systemic antivirals

          -  History of interstitial lung disease

          -  Has a history of (non-infectious) pneumonitis that required steroids or has current
             pneumonitis