Inclusion Criteria:

          -  Age ≥ 18 years at the time of informed consent

          -  Histologically confirmed diagnosis of melanoma. Any primary or unknown origin is
             permitted.

          -  Melanoma must have a BRAFV600 mutation (using a CLIA-validated assay), either stage
             III (B/C/D) or Stage IV (AJCC 8th edition).

          -  ECOG performance status ≤ 2

          -  Adequate laboratory parameters as well:

          -  a. Hemoglobin ≥ 8 g/dL.

          -  b. Platelets ≥ 75 × 109/L;

          -  c. AST and ALT ≤ 2.5 × ULN; in participants with liver metastases ≤ 5 × ULN;

          -  d. Total bilirubin ≤ 1.5 × ULN and < 2 mg/dL; OR total bilirubin >1.5 × ULN with
             indirect bilirubin < 1.5 × ULN;

          -  e. Serum creatinine ≤ 2.0 × ULN

          -  Female participants of childbearing potential as described in protocol, must have a
             negative serum or urine β-HCG test result. Female participants of childbearing
             potential must agree to use methods of contraception that are highly effective or
             acceptable, as described in Section 4.3.1. Participants must agree to not use hormonal
             contraceptives, as encorafenib can result in decreased concentration and loss of
             efficacy. Male participants must agree to use methods of contraception that are highly
             effective or acceptable per protocol.

        Exclusion Criteria:

          -  Participants may have received prior therapy with BRAF and/or a MEK inhibitor if it
             was completed at least 6 months prior to study enrollment. Patients who had prior
             disease progression while on BRAF/MEK inhibitor therapy are not eligible. (Progression
             after stopping treatment is permitted.) Participants may have received prior therapy
             an anti-PD-1/PD-L1 or CTLA-4 inhibitor.

          -  Participants must not have had adverse events related to encorafenib and/or
             binimetinib specifically, that required discontinuation of one or both drugs due to
             toxicity.

          -  Participants who have had major surgery or radiotherapy ≤ 14 days prior to start of
             study treatment or who have not recovered from side effects of such procedure.

          -  Participants must be willing to avoid consuming grapefruit, pomegranates, star fruits,
             Seville oranges or products containing the juice during the study while they are
             taking encorafenib/binimetinib.

          -  Uncontrolled or symptomatic brain metastases or leptomeningeal carcinomatosis that are
             not stable, require steroids, are potentially life-threatening or have required
             radiation within 28 days prior to starting study drug. Patients with previously
             treated brain metastases may participate provided they are stable (e.g.,without
             evidence of progression by radiographic imaging for at least 28 days before the first
             dose of study treatment and neurologic symptoms have returned to baseline).

          -  Impaired cardiovascular function as below:

          -  a. Congestive heart failure requiring treatment (New York Heart Association Grade ≥
             3);

          -  b. presence of uncontrolled atrial fibrillation or uncontrolled paroxysmal
             supraventricular tachycardia

          -  c. Baseline QTcF interval ≥ 500 ms.

          -  Known history of retinal vein occlusion (RVO)

          -  Current use of a prohibited medication (including herbal medications, supplements, or
             foods), as described in protocol, or use of a prohibited medication ≤ 1 week prior to
             the start of study treatment.

          -  Participants with a prior or concurrent malignancy whose natural history or treatment
             (in the opinion of the treating physician) does not have the potential to interfere
             with the safety or efficacy assessment of the investigational regimen are eligible for
             this trial.

          -  Participants with known human immunodeficiency virus (HIV)-infection are eligible
             providing they are on effective anti-retroviral therapy and have undetectable viral
             load at their most recent viral load test and within 90 days prior to randomization.

          -  Participants with a known history of hepatitis C virus (HCV) infection must have been
             treated and cured. Participants with HCV infection who are currently on treatment must
             have an undetectable HCV viral load prior to randomization.

          -  Pregnancy or breast feeding.