Key Inclusion Criteria:

          -  Relapse/refractory (r/r) de novo or secondary acute myeloid leukemia (AML)

          -  Morphological disease in the bone marrow and/or peripheral blood within 28 days before
             enrollment

          -  Prior exposure to the relevant agent class for individuals with AML characterized by a
             mutation targeted by an approved therapy

          -  Institutional criteria for allo-SCT fitness must be met: individuals must have an
             identified stem-cell donor readily available for potential allo-SCT after therapy with
             KITE-222

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

          -  Adequate hematologic status, defined as:

               -  Absolute neutrophil count (ANC) ≥ 1000/µL unless, in the opinion of the
                  investigator, cytopenia is due to underlying leukemia

               -  Platelet count ≥ 50,000/µL unless, in the opinion of the investigator,
                  thrombocytopenia is due to underlying leukemia

               -  Absolute lymphocyte count (ALC) ≥ 100/µL

          -  Adequate renal, hepatic, pulmonary and cardiac function defined as:

               -  Creatinine clearance (as estimated by the Cockcroft Gault formula) ≥ 60 mL/min

               -  Serum alanine aminotransferase/aspartate aminotransferase ≤ 2.5 x upper limit of
                  normal

               -  Total bilirubin ≤ 1.5 mg/dL, except in individuals with Gilbert's syndrome

               -  Cardiac ejection fraction ≥ 50%, no clinically significant pericardial effusion
                  as determined by an echocardiogram (ECHO), and no clinically significant
                  electrocardiogram (ECG) findings

               -  Baseline oxygen saturation > 92% on room air and no clinically significant
                  pleural effusion as determined by chest imaging

          -  Contraception: males and females of childbearing potential must agree to use an
             effective method of contraception

          -  Pregnancy testing: females of childbearing potential must have a negative serum or
             urine pregnancy test

        Key Exclusion Criteria:

          -  Diagnosis of acute promyelocytic leukemia

          -  Auto-SCT within the 6 weeks before enrollment

          -  Donor Lymphocyte Infusions (DLI) within 28 days prior to enrollment

          -  Any drug used for graft-versus-host-disease (GVHD) within 4 weeks prior to enrollment

          -  Acute GVHD grade II-IV by Mount Sinai Acute GVHD International Consortium criteria

          -  Active central nervous system (CNS) disease involvement

          -  Requirement for urgent therapy due to ongoing or impending oncologic emergency (eg,
             leukostasis or tumor lysis syndrome (TLS)) or the possible requirement for urgent
             therapy due to ongoing or impending oncologic emergency (eg, spinal cord compression,
             bowel obstruction, leukostasis, or TLS) at the time of enrollment or KITE-222 infusion

          -  History of C-type lectin-like molecule-1 (CLL-1)-directed therapy or genetically
             modified T-cell therapy

          -  History of malignancy other than nonmelanoma skin cancer or carcinoma in situ (eg,
             cervix, bladder, or breast) unless disease free for at least 3 years after the last
             definitive therapy

          -  History of severe hypersensitivity reaction to aminoglycosides

          -  History of concomitant genetic syndrome associated with bone marrow failure

          -  Individuals with a genetic syndrome that increases the risk of allo-SCT, including
             Down syndrome (trisomy 21)

          -  History of myocardial infarction, cardiac angioplasty or stenting, unstable angina,
             New York Heart Association Class II or greater congestive heart failure, atrial
             fibrillation, or other clinically significant cardiac disease within 12 months before
             enrollment

          -  Individuals with cardiac atrial or ventricular leukemia involvement

          -  History of symptomatic deep vein thrombosis (DVT) or a pulmonary embolism within 6
             months of enrollment. History of upper extremity line related DVT within the 3 months
             of conditioning chemotherapy.

          -  Primary immunodeficiency disorders

          -  History of a human immunodeficiency virus (HIV) infection or acute or chronic active
             hepatitis B or C infection

          -  History of an autoimmune disease resulting in end-organ injury or requiring systemic
             immunosuppression or systemic disease modifying agents within the last 2 years

          -  History or presence of a CNS disorder

          -  Presence or suspicion of a fungal, bacterial, viral, or other infection that is
             uncontrolled or requiring antimicrobials for management

          -  Live vaccine received within the ≤ 4 weeks before enrollment, or anticipation of the
             need for a live vaccination during the course of the study

          -  Inability to tolerate prophylactic antifungal and antibacterial therapy

          -  Presence of any indwelling line or drain

          -  Ongoing Grade 2 or higher toxicities from previous therapies, excluding hematologic
             toxicities

          -  Females of childbearing potential who are pregnant or breastfeeding

        Note: Other protocol defined Inclusion/Exclusion criteria may apply.