Inclusion Criteria:

          1. Age >/= 18 years of age with evaluable locally advanced unresectable or metastatic
             TNBC.

          2. Documentation of triple negative breast cancer (estrogen and progesterone receptor <1%
             and HER2-negative)

          3. Prior systemic therapies (Cohort 1 only):

               1. No prior systemic therapy in the locally advanced unresectable/metastatic setting
                  including chemotherapy, targeted therapy, immunotherapy, or investigational
                  agents.

               2. Prior PD-1/PD-L1 inhibitor treatment is not permitted in any setting, including
                  in the neoadjuvant setting.

               3. Time between completion of last treatment with curative intent and first
                  metastatic recurrence must be ≥ 6 months.

          4. Prior systemic therapies (Cohort 2 only):

               1. Documentation of PD-L1 positive status

               2. Treated with a PD-1/PD-L1 inhibitor for a minimum duration of 4 months in the
                  locally advanced unresectable/metastatic setting and as the most recent therapy.

          5. Radiation therapy for metastatic disease is permitted. There is no required minimum
             washout period for radiation therapy. Patients should be recovered from the effects of
             radiation.

          6. Archival tumor tissue must be available or a fresh biopsy must be obtained, unless
             approved by the Medical Monitor.

          7. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

          8. Adequate organ function as demonstrated by normal laboratory values

        Exclusion Criteria:

          1. Prior treatment with gemcitabine in any setting.

          2. Prior treatment with carboplatin in the locally advanced unresectable/metastatic
             setting.

             Prior carboplatin in the (neo)adjuvant/curative setting is permitted as long as it was
             completed ≥ 6 months prior to the first metastatic recurrence.

          3. Presence of central nervous system (CNS) metastases and/or leptomeningeal disease
             requiring immediate treatment with radiation therapy or steroids.

          4. Receipt of any cytotoxic chemotherapy within 14 days prior to the first dose of study
             drugs.

          5. QTcF interval >480 msec at Screening (confirmed in triplicate). For patients with
             ventricular pacemakers, QTcF >500 msec.

          6. Known hypersensitivity to carboplatin or other platinum-containing compounds, or
             mannitol

          7. Pregnant or lactating women

          8. Prior hematopoietic stem cell or bone marrow transplantation