Inclusion Criteria:

          -  Ages 4-21 years.

          -  Subjects with evidence of clinical and/or radiographic progression of Diffuse Midline
             Glioma

          -  Radiological diagnosis of DMG with tumor involving the pons (intrinsic, pontine based
             infiltrative lesion; hypointense in T1 weighted images (T1WIs) and hyperintense in T2
             sequences, with mass effect on the adjacent structures and occupying at least 50% of
             the pons), thalami and/or histological confirmation of H3K27M mutation confirmation of
             pontine or thalamic glioma.

          -  Subjects must be healthy enough to tolerate FUS and MRI and any anesthesia necessary
             based on the opinion of the principal investigator. Subjects must also be able to
             swallow capsules (for Panobinostat dosing). Other criteria include, but is not limited
             to:

        Prior therapy:

        • Patients must have fully recovered from the acute toxic effects of all prior anti-cancer
        therapy and must meet the following minimum duration from prior anti-cancer directed
        therapy prior to enrollment.

          -  Cytotoxic chemotherapy or anti-cancer agents known to be myelosuppressive: At least 21
             days after the last dose of cytotoxic or myelosuppressive chemotherapy.

          -  Anti-cancer agents not known to be myelosuppressive: At least 7 days must have elapsed
             from last dose of agent.

          -  Antibodies: At least 21 days must have elapsed from infusion of last dose of antibody.

          -  Interleukins, Interferons, and Cytokines: At least 21 days must have elapsed since the
             completion of interleukins, interferon, or cytokines.

          -  Stem cell infusions: At least 42 days must have elapsed after completion of an
             autologous stem cell infusion, and at least 84 days must have elapsed after completion
             of an allogeneic stem cell infusion.

          -  Cellular therapy: At least 42 days must have elapsed since the completion of any type
             of cellular therapy

          -  Radiotherapy (XRT): At least 1 month must have elapsed after local XRT.

          -  Subjects must be on a stable or decreasing dose of steroids, as well as stable dose of
             anti-seizure medication for 1 week.

        Performance status:

        • Karnofsky performance status or Lansky play score of ≥70

        Hepatic:

          -  Total bilirubin: within normal institutional limits

          -  Aspartate Aminotransferase (AST, SGOT)/Alanine aminotransferase (ALT, SGPT): ≤ 2.5 ×
             institutional upper limit of normal

        Renal:

          -  Creatinine: within normal institutional limits

          -  Creatinine clearance: ≥ 60 mL/min/1.73m2 for subjects with creatinine levels above
             institutional normal

        Hematopoietic:

          -  Absolute neutrophil count: ≥ 1,500/μL

          -  Platelet count: ≥ 100,000/μL

          -  Hemoglobin level: ≥ 10g/dL

          -  Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT):
             within normal institutional limits

          -  No documented current bleeding disorder

        Other:

          -  Not pregnant or nursing - negative serum pregnancy test, if of childbearing potential,
             within 7 days of study entry

          -  Subjects with a history of seizures/epilepsy should be on anti-convulsant medication
             prior to the first operative procedure on the study.

          -  Subjects must undergo a baseline EKG within 7 days of study enrollment.

          -  Subjects must be able to undergo MR imaging with gadolinium-based contrast
             administration (e.g. no ferrous-containing implants, no pacemakers, etc.)

          -  All subjects or their legal guardians must sign a document of informed consent
             indicating their understanding of the investigational nature and the potential risks
             associated with this study. When appropriate, pediatric subjects will be included in
             all discussions in order to obtain verbal and written assent

        Exclusion Criteria:

          -  Subjects with spinal DMGs.

          -  Subjects with a medical condition that would preclude general anesthesia

          -  Subjects with evidence of any active infection

          -  Subjects with documented allergy to compounds of similar chemical or biologic
             composition to Panobinostat or gadolinium compounds

          -  Subjects with evidence of tumor hemorrhage

          -  Subjects with an uncorrectable bleeding disorder

          -  Subjects with signs of impending herniation or an acute intratumoral hemorrhage

          -  Subjects with systemic diseases which may be associated with unacceptable
             anesthetic/operative risk

          -  Subjects with implanted electrical devices, metallic implants

          -  Subjects with uncontrollable hypertension

          -  Subjects with a history of stroke or cardiovascular disease

          -  Subjects with cerebrovascular diseases

          -  Subjects with coagulopathy or under anticoagulant therapy.

          -  Pregnant or breast-feeding women will not be entered on this study, since there is yet
             no available information regarding human fetal or teratogenic toxicities. A pregnancy
             test must be obtained in girls who are post-menarchal. Males with female partners of
             reproductive potential or females of reproductive potential may not participate unless
             they have agreed to use two effective methods of birth control- including a medically
             accepted barrier method of contraception (e.g., a male or female condom) for the
             entire period in which they are receiving protocol therapy and for at least 1 week
             following their last study treatment requirement. Abstinence is an acceptable method
             of birth control.