Inclusion Criteria:

          1. Must be ≥18 and ≤70 years of age.

          2. Must have confirmed diagnosis of AML in first or second complete remission (CR1 or
             CR2) or have bone marrow blasts ≤10% without circulating blasts.

          3. AML sample from the patient must have evidence of CD33 expression (>0%)

          4. AML must have intermediate or high-risk disease-related genetics and the presence of
             minimal residual disease (MRD). Subjects in CR2 or with persistent morphologic blasts;
             may have favorable disease-related genetics.

          5. Candidate for HLA-matched allogeneic HCT using a myeloablative conditioning regimen.

          6. Must have a related or unrelated stem cell donor that is a 10/10 match for HLA-A, -B,
             -C, -DRB1 and -DQB1.

          7. Must have adequate performance status and organ function as defined below:

               1. Performance Status: Karnofsky score of ≥70.

               2. Cardiac: left ventricular ejection fraction (LVEF) ≥50%

               3. Pulmonary: diffusing capacity of lung for carbon monoxide (DLCO), forced vital
                  capacity (FVC), and forced expiratory volume in one second (FEV1) ≥66%.

               4. Renal: estimated glomerular filtration rate (GFR) >60 mL/min

               5. Hepatic: total bilirubin <1.5 × ULN, or if ≥1.5 × ULN direct bilirubin <ULN and
                  ALT/AST <1.5 × ULN (per institutional criteria).

        Exclusion Criteria:

          1. Prior autologous or allogeneic stem cell transplantation.

          2. Presence of the following disease-related genetics: t(15; 17)(q22; q21), or t(9;
             22)(q34; q11), or other evidence of acute promyelocytic leukemia or chronic myeloid
             leukemia.

          3. Prior treatment with Mylotarg™ (gemtuzumab ozogamicin).

          4. Active central nervous system (CNS) leukemia or history of other active
             malignancy(ies).

          5. Patients diagnosed with Gilbert's syndrome.

          6. Uncontrolled bacterial, viral, or fungal infections; or known human immunodeficiency
             virus (HIV), Hepatitis B, or Hepatitis C infection.