Inclusion Criteria:

          -  Participants must satisfy the following criteria to be enrolled in the study:

               1. Is ≥ 18 years of age at the time of signing the informed consent form (ICF).

               2. Participant has histologically confirmed (per local evaluation) diagnosis of de
                  novo, previously untreated, a-BCL according to 2016 WHO classification.

               3. Participant has poor-risk disease defined as International Prognostic Index (IPI)
                  score ≥ 3 (high-intermediate or high-risk).

               4. Participants must have measurable disease defined by at least one FDG-avid lesion
                  for FDGavid subtype and one bi-dimensionally measurable (> 1.5 cm in longest
                  diameter) disease by computed tomography (CT) or magnetic resonance imaging
                  (MRI), as defined by the Lugano classification (Cheson, 2014).

               5. Participant has an Eastern Cooperative Oncology Group (ECOG) performance status
                  of 0, 1, or 2.

               6. Participants must have the following laboratory values:

                    1. Absolute neutrophil count (ANC) ≥ 1.5 x 109/L or ≥ 1.0 x 109/L in case of
                       documented bone marrow involvement (> 50% or tumor cells), without growth
                       factor support for 7 days (14 days if peg-G-CSF)

                    2. Hemoglobin (Hb) ≥ 8 g/dL

                    3. Platelets (PLT) ≥ 75 x 109/L or ≥ 50 x 109/L in case of documented bone
                       marrow involvement (>50% or tumor cells), without transfusion for 7 days

                    4. Aspartate aminotransferase / serum glutamic oxaloacetic transaminase
                       (AST/SGOT) and alanine aminotransferase / serum glutamate pyruvic
                       transaminase (ALT/SGPT) ≤ 2.5 x upper limit of normal (ULN). In the case of
                       documented liver involvement by lymphoma, ALT/SGPT and AST/SGOT must be ≤
                       5.0 x ULN.

                    5. Serum total bilirubin ≤ 2.0 mg/dL except in cases of Gilbert syndrome, then
                       ≤ 5.0 mg/dl

                    6. Estimated serum creatinine clearance of ≥ 50 mL/min

               7. All participants must:

                    1. Have an understanding that the study drug could have a potential teratogenic
                       risk.

                    2. Agree to follow all requirements defined in the Pregnancy Prevention Program
                       for CC-220 or CC-99282 Pregnancy Prevention Plan for Participants in
                       Clinical trials.

               8. Females of childbearing potential (FCBP) must:

                  a. Have two negative pregnancy tests as verified by the investigator prior to
                  starting study therapy.

               9. Male participants must:

                    1. Practice true abstinence or agree to use a condom during sexual contact with
                       a pregnant female or a female of childbearing potential while participating
                       in the study.

        Exclusion Criteria:

          -  The presence of any of the following will exclude a participant from enrollment:

               1. Any significant medical condition, active infection (including SARS-CoV-2
                  suspected or confirmed), laboratory abnormality, or psychiatric illness that
                  would prevent the participant from participating in the study.

               2. Any condition including the presence of laboratory abnormalities, which places
                  the participant at unacceptable risk if he/she were to participate in the study.

               3. Any other subtype of lymphoma.

               4. Documented or suspected CNS involvement by lymphoma.

               5. Persistent diarrhea or malabsorption ≥ Grade 2 (NCI CTCAE v5.0), despite medical
                  management.

               6. Peripheral neuropathy ≥ Grade 2 (NCI CTCAE v5.0).

               7. Chronic systemic immunosuppressive therapy or corticosteroids

               8. Impaired cardiac function or clinically significant cardiac disease, including
                  any of the following:

                  a. Left ventricular ejection fraction (LVEF) < 45% as determined by multigated
                  acquisition scan (MUGA) or echocardiogram (ECHO)

               9. Major surgery ≤ 2 weeks prior to starting CC-220 or CC-99282; participant must
                  have recovered from any clinically significant effects of recent surgery.

              10. Any condition causing inability to swallow tablets.

              11. Known seropositivity for or active viral infection with human immunodeficiency
                  virus (HIV)

              12. Known chronic active hepatitis B (hepatitis B surface antigen [HBsAg] positive
                  and/or hepatitis B core antibody [anti-HBc] positive with viral DNA positive) or
                  C (positive serology requiring treatment and/or with evidence of liver damage)
                  infection

              13. History of other malignancy, unless being free of the disease for ≥ 3 years;
                  exceptions to the ≥ 3-year time limit include history of the following:

                    1. Localized nonmelanoma skin cancer

                    2. Carcinoma in situ of the cervix

                    3. Carcinoma in situ of the breast

                    4. Incidental histologic finding of prostate cancer (T1a or T1b as per Tumor
                       Node Metastasis [TNM] staging system) or prostate cancer that has been
                       treated with curative intent.

              14. Hypersensitivity to the active substance or to murine proteins, or to any of the
                  other excipients of rituximab.

              15. Known hypersensitivity to any component of CHOP regimen.

              16. Known allergy to thalidomide, pomalidomide, or lenalidomide.